Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells

• Published in: International journal of oncology Vol. 46; no. 2; pp. 474 - 486
• Main Authors: MORIYA, SHOTA, KOMATSU, SEIICHIRO, YAMASAKI, KAHO, KAWAI, YUSUKE, KOKUBA, HIROKO, HIROTA, AYAKO, CHE, XIAO-FANG, INAZU, MASATO, GOTOH, AKIHIKO, HIRAMOTO, MASAKI, MIYAZAWA, KEISUKE
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.02.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: aggresome; Animals; Antibiotics; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy (Cytology); Autophagy - drug effects; Boronic Acids - administration & dosage; Bortezomib; Cell death; Cell Line, Tumor; Clarithromycin - administration & dosage; Drug Synergism; Drug therapy; Endoplasmic reticulum; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum Stress - drug effects; ER stress; Health aspects; Histone Deacetylase 6; Histone Deacetylases - drug effects; Humans; Hydroxamic Acids - administration & dosage; Investigations; Kinases; Mice; Multiple myeloma; Multiple Myeloma - drug therapy; Multiple Myeloma - genetics; Multiple Myeloma - pathology; Physiological aspects; proteasome; Proteasome Endopeptidase Complex - drug effects; Proteins; Pyrazines - administration & dosage; Japan

The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simultaneous blocking of the ubiquitin (Ub)-proteasome...