Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells - MORIYA, SHOTA; KOMATSU, SEIICHIRO; YAMASAKI, KAHO; KAWAI, YUSUKE; KOKUBA, HIROKO; HIROTA, AYAKO; CHE, XIAO-FANG; INAZU, MASATO; GOTOH, AKIHIKO; HIRAMOTO, MASAKI; MIYAZAWA, KEISUKE (International journal of oncology, 2015)
Keywords: aggresome; Animals; Antibiotics; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy (Cytology); Autophagy - drug effects; Boronic Acids - administration & dosage; Bortezomib; Cell death; Cell Line, Tumor; Clarithromycin - administration & dosage; Drug Synergism; Drug therapy; Endoplasmic reticulum; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum Stress - drug effects; ER stress; Health aspects; Histone Deacetylase 6; Histone Deacetylases - drug effects; Humans; Hydroxamic Acids - administration & dosage; Investigations; Kinases; Mice; Multiple myeloma; Multiple Myeloma - drug therapy; Multiple Myeloma - genetics; Multiple Myeloma - pathology; Physiological aspects; proteasome; Proteasome Endopeptidase Complex - drug effects; Proteins; Pyrazines - administration & dosage; Japan