The Keystone commensal bacterium Christensenella minuta DSM 22607 displays anti-inflammatory properties both in vitro and in vivo
Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining microbial symbiosis. Indeed, these bacteria occur at significantly lower levels or are absent in individuals suffering from inflammatory bowel disea...
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Published in | Scientific reports Vol. 11; no. 1; pp. 11494 - 12 |
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01.06.2021
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Abstract | Christensenellaceae
is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining microbial symbiosis. Indeed, these bacteria occur at significantly lower levels or are absent in individuals suffering from inflammatory bowel diseases (IBDs). Here, we explored if type species
Christensenella minuta
(strain: DSM 22607) could have the potential to help treat IBDs. We assessed key properties displayed by the bacterium using a combination of in vitro and in vivo assays. We found that while
C. minuta
is a strict anaerobe, it is also oxygen tolerant. Additionally, we observed that the species produces high levels of acetate and moderate levels of butyrate. We performed deep phenotyping using Biolog microarrays. Using human intestinal cell lines, we discovered that
C. minuta
demonstrated strong anti-inflammatory activity, resulting in reduced levels of proinflammatory IL-8 cytokines via the inhibition of the NF-
κ
B signaling pathway. Furthermore,
C. minuta
protected intestinal epithelial integrity in vitro. Finally, in two distinct animal models of acute colitis,
C. minuta
prevented intestinal damage, reduced colonic inflammation, and promoted mucosal healing. Together, these results indicate that
C. minuta
has potent immunomodulatory properties, underscoring its potential use in innovative microbiome-based IBD biotherapies. |
---|---|
AbstractList | Abstract Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining microbial symbiosis. Indeed, these bacteria occur at significantly lower levels or are absent in individuals suffering from inflammatory bowel diseases (IBDs). Here, we explored if type species Christensenella minuta (strain: DSM 22607) could have the potential to help treat IBDs. We assessed key properties displayed by the bacterium using a combination of in vitro and in vivo assays. We found that while C. minuta is a strict anaerobe, it is also oxygen tolerant. Additionally, we observed that the species produces high levels of acetate and moderate levels of butyrate. We performed deep phenotyping using Biolog microarrays. Using human intestinal cell lines, we discovered that C. minuta demonstrated strong anti-inflammatory activity, resulting in reduced levels of proinflammatory IL-8 cytokines via the inhibition of the NF-κB signaling pathway. Furthermore, C. minuta protected intestinal epithelial integrity in vitro. Finally, in two distinct animal models of acute colitis, C. minuta prevented intestinal damage, reduced colonic inflammation, and promoted mucosal healing. Together, these results indicate that C. minuta has potent immunomodulatory properties, underscoring its potential use in innovative microbiome-based IBD biotherapies. Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining microbial symbiosis. Indeed, these bacteria occur at significantly lower levels or are absent in individuals suffering from inflammatory bowel diseases (IBDs). Here, we explored if type species Christensenella minuta (strain: DSM 22607) could have the potential to help treat IBDs. We assessed key properties displayed by the bacterium using a combination of in vitro and in vivo assays. We found that while C. minuta is a strict anaerobe, it is also oxygen tolerant. Additionally, we observed that the species produces high levels of acetate and moderate levels of butyrate. We performed deep phenotyping using Biolog microarrays. Using human intestinal cell lines, we discovered that C. minuta demonstrated strong anti-inflammatory activity, resulting in reduced levels of proinflammatory IL-8 cytokines via the inhibition of the NF- κ B signaling pathway. Furthermore, C. minuta protected intestinal epithelial integrity in vitro. Finally, in two distinct animal models of acute colitis, C. minuta prevented intestinal damage, reduced colonic inflammation, and promoted mucosal healing. Together, these results indicate that C. minuta has potent immunomodulatory properties, underscoring its potential use in innovative microbiome-based IBD biotherapies. Abstract Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining microbial symbiosis. Indeed, these bacteria occur at significantly lower levels or are absent in individuals suffering from inflammatory bowel diseases (IBDs). Here, we explored if type species Christensenella minuta (strain: DSM 22607) could have the potential to help treat IBDs. We assessed key properties displayed by the bacterium using a combination of in vitro and in vivo assays. We found that while C. minuta is a strict anaerobe, it is also oxygen tolerant. Additionally, we observed that the species produces high levels of acetate and moderate levels of butyrate. We performed deep phenotyping using Biolog microarrays. Using human intestinal cell lines, we discovered that C. minuta demonstrated strong anti-inflammatory activity, resulting in reduced levels of proinflammatory IL-8 cytokines via the inhibition of the NF- κ B signaling pathway. Furthermore, C. minuta protected intestinal epithelial integrity in vitro. Finally, in two distinct animal models of acute colitis, C. minuta prevented intestinal damage, reduced colonic inflammation, and promoted mucosal healing. Together, these results indicate that C. minuta has potent immunomodulatory properties, underscoring its potential use in innovative microbiome-based IBD biotherapies. Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining microbial symbiosis. Indeed, these bacteria occur at significantly lower levels or are absent in individuals suffering from inflammatory bowel diseases (IBDs). Here, we explored if type species Christensenella minuta (strain: DSM 22607) could have the potential to help treat IBDs. We assessed key properties displayed by the bacterium using a combination of in vitro and in vivo assays. We found that while C. minuta is a strict anaerobe, it is also oxygen tolerant. Additionally, we observed that the species produces high levels of acetate and moderate levels of butyrate. We performed deep phenotyping using Biolog microarrays. Using human intestinal cell lines, we discovered that C. minuta demonstrated strong anti-inflammatory activity, resulting in reduced levels of proinflammatory IL-8 cytokines via the inhibition of the NF-κB signaling pathway. Furthermore, C. minuta protected intestinal epithelial integrity in vitro. Finally, in two distinct animal models of acute colitis, C. minuta prevented intestinal damage, reduced colonic inflammation, and promoted mucosal healing. Together, these results indicate that C. minuta has potent immunomodulatory properties, underscoring its potential use in innovative microbiome-based IBD biotherapies. Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining microbial symbiosis. Indeed, these bacteria occur at significantly lower levels or are absent in individuals suffering from inflammatory bowel diseases (IBDs). Here, we explored if type species Christensenella minuta (strain: DSM 22607) could have the potential to help treat IBDs. We assessed key properties displayed by the bacterium using a combination of in vitro and in vivo assays. We found that while C. minuta is a strict anaerobe, it is also oxygen tolerant. Additionally, we observed that the species produces high levels of acetate and moderate levels of butyrate. We performed deep phenotyping using Biolog microarrays. Using human intestinal cell lines, we discovered that C. minuta demonstrated strong anti-inflammatory activity, resulting in reduced levels of proinflammatory IL-8 cytokines via the inhibition of the NF- κ B signaling pathway. Furthermore, C. minuta protected intestinal epithelial integrity in vitro. Finally, in two distinct animal models of acute colitis, C. minuta prevented intestinal damage, reduced colonic inflammation, and promoted mucosal healing. Together, these results indicate that C. minuta has potent immunomodulatory properties, underscoring its potential use in innovative microbiome-based IBD biotherapies. |
ArticleNumber | 11494 |
Author | Langella, Philippe Le Corf, Katy Chain, Florian Kropp, Camille Claus, Sandrine P. Martinez, Ccori Martin, Rebeca Tambosco, Kevin Relizani, Karima Rawadi, Georges |
Author_xml | – sequence: 1 givenname: Camille surname: Kropp fullname: Kropp, Camille organization: Micalis Institute, AgroParisTech, INRAE, Université Paris-Saclay, Ysopia Bioscience – sequence: 2 givenname: Katy surname: Le Corf fullname: Le Corf, Katy organization: Ysopia Bioscience – sequence: 3 givenname: Karima surname: Relizani fullname: Relizani, Karima organization: Ysopia Bioscience – sequence: 4 givenname: Kevin surname: Tambosco fullname: Tambosco, Kevin organization: Micalis Institute, AgroParisTech, INRAE, Université Paris-Saclay – sequence: 5 givenname: Ccori surname: Martinez fullname: Martinez, Ccori organization: Ysopia Bioscience – sequence: 6 givenname: Florian surname: Chain fullname: Chain, Florian organization: Micalis Institute, AgroParisTech, INRAE, Université Paris-Saclay – sequence: 7 givenname: Georges surname: Rawadi fullname: Rawadi, Georges organization: Ysopia Bioscience – sequence: 8 givenname: Philippe surname: Langella fullname: Langella, Philippe organization: Micalis Institute, AgroParisTech, INRAE, Université Paris-Saclay – sequence: 9 givenname: Sandrine P. surname: Claus fullname: Claus, Sandrine P. organization: Ysopia Bioscience – sequence: 10 givenname: Rebeca surname: Martin fullname: Martin, Rebeca email: rebeca.martin-rosique@inrae.fr organization: Micalis Institute, AgroParisTech, INRAE, Université Paris-Saclay |
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Keywords | anti-inflammatory Properties |
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Snippet | Christensenellaceae
is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining... Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining... Abstract Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by... Abstract Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by... |
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SubjectTerms | 631/326/1320 631/326/41/2533 Acetic acid Animal models Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Bacteria Caco-2 Cells Cell lines Clostridiales Colitis Colitis - chemically induced Colitis - metabolism Colitis - therapy Cytokines Disease Models, Animal HT29 Cells Humanities and Social Sciences Humans Hypotheses Immune system Immunomodulation Inflammation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 8 Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestine Life Sciences Male Metabolism Metabolites Mice Microbiomes Microbiota Mucosa multidisciplinary NF-κB protein Phenotyping Science Science (multidisciplinary) Signal transduction Symbiosis |
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Title | The Keystone commensal bacterium Christensenella minuta DSM 22607 displays anti-inflammatory properties both in vitro and in vivo |
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