First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol

• Published in: Regenerative therapy Vol. 18; pp. 321 - 333
• Main Authors: Sugai, Keiko, Sumida, Miho, Shofuda, Tomoko, Yamaguchi, Ryo, Tamura, Takashi, Kohzuki, Tsuneo, Abe, Takayuki, Shibata, Reo, Kamata, Yasuhiro, Ito, Shuhei, Okubo, Toshiki, Tsuji, Osahiko, Nori, Satoshi, Nagoshi, Narihito, Yamanaka, Shinya, Kawamata, Shin, Kanemura, Yonehiro, Nakamura, Masaya, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021; Japanese Society for Regenerative Medicine; Elsevier
• Subjects: Induced pluripotent stem cells; Neural stem/progenitor cells; Original; Regenerative medicine; Spinal cord injury; Transplantation; Transplantation; Spinal cord injury; Induced pluripotent stem cells; Regenerative medicine; Neural stem/progenitor cells

Our group has conducted extensive basic and preclinical studies of the use of human induced pluripotent cell (iPSC)-derived neural stem/progenitor cell (hiPSC-NS/PC) grafts in models of spinal cord injury (SCI). Evidence from animal experiments suggests this approach is safe and effective. We are pr...