Impact of neonatal early-onset sepsis calculator on antibiotic use within two tertiary healthcare centers

Objective: A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS. Study D...

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Published inJournal of perinatology Vol. 37; no. 4; pp. 394 - 397
Main Authors Warren, S, Garcia, M, Hankins, C
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.04.2017
Nature Publishing Group
Subjects
692/699/255/1318
692/700/1720
Age
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antiinfectives and antibacterials
Birth
Birth weight
Blood
Care and treatment
Centers for Disease Control and Prevention (U.S.)
Childbirth & labor
Diagnosis
Disease control
Diseases
Dosage and administration
Drug therapy
Electronic health records
Female
Gestational age
Health aspects
Humans
Infant, Newborn
Infants
Infants (Newborn)
Male
Mathematical analysis
Medical records
Medicine
Medicine & Public Health
Membranes
Neonatal Sepsis - diagnosis
Neonatal Sepsis - drug therapy
Neonates
Neutrophils
Newborn babies
original-article
Pediatric Surgery
Pediatrics
Practice Guidelines as Topic
Retrospective Studies
Risk Factors
Sepsis
Tertiary Care Centers
Testing
United States
United States
United States > US
Online AccessGet full text
ISSN0743-8346
1476-5543
1476-5543
DOI10.1038/jp.2016.236

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Abstract Objective: A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS. Study Design: Retrospective review of infants ⩾34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations. Results: Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines ( P <0.001). No cases of culture-positive sepsis were identified. Conclusion: Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
AbstractList Objective:A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS.Study Design:Retrospective review of infants ⩾34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations.Results:Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P<0.001). No cases of culture-positive sepsis were identified.Conclusion:Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS. Retrospective review of infants [greater-than or slanted equal to]34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations. Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P<0.001). No cases of culture-positive sepsis were identified. Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS.OBJECTIVEA recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS.Retrospective review of infants ⩾34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations.STUDY DESIGNRetrospective review of infants ⩾34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations.Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P<0.001). No cases of culture-positive sepsis were identified.RESULTSOf 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P<0.001). No cases of culture-positive sepsis were identified.Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.CONCLUSIONUse of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
Objective: A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS. Study Design: Retrospective review of infants [greater-than or slanted equal to]34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations. Results: Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P<0.001). No cases of culture-positive sepsis were identified. Conclusion: Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
Objective: A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS.Study Design:Retrospective review of infants [egs]34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations. Results: Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P<0.001). No cases of culture-positive sepsis were identified. Conclusion: Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
Objective: A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS. Study Design: Retrospective review of infants [succeeds/equal to]34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations. Results: Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P [less than] 0.001). No cases of culture-positive sepsis were identified. Conclusion: Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed. Journal of Perinatology (2017) 37, 394-397; doi: 10.1038/jp.2016.236; published online 22 December 2016
Objective:A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS.Study Design:Retrospective review of infants [= or >, slanted]34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations.Results:Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P<0.001). No cases of culture-positive sepsis were identified.Conclusion:Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
Objective: A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS. Study Design: Retrospective review of infants ⩾34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations. Results: Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines ( P <0.001). No cases of culture-positive sepsis were identified. Conclusion: Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS. Retrospective review of infants [succeeds/equal to]34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations. Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P [less than] 0.001). No cases of culture-positive sepsis were identified. Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use remains sparse. The objective of this study was to determine the impact of applying the calculator to infants treated for EOS. Retrospective review of infants ⩾34 weeks gestational age who received antibiotics at birth. Subjects were compared according to Centers for Disease Control (CDC) 2010 guideline criteria versus the Kaiser Permanente neonatal EOS calculator recommendations. Of 205 patients, the EOS calculator recommended empiric antibiotics for 23% of those who received therapy, compared with 92% per CDC guidelines (P<0.001). No cases of culture-positive sepsis were identified. Use of the neonatal EOS calculator may dramatically reduce the number of infants who require antibiotics at birth, leading to reduced need for laboratory monitoring and improved antimicrobial stewardship. More safety data is needed.
Audience Academic
Author Warren, S
Garcia, M
Hankins, C
Author_xml – sequence: 1
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  organization: Providence Portland Medical Center
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  surname: Hankins
  fullname: Hankins, C
  organization: Providence St. Vincent Medical Center
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28005063$$D View this record in MEDLINE/PubMed
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Snippet Objective: A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from...
A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from its use...
Objective: A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from...
Objective:A recently described neonatal early-onset sepsis (EOS) calculator has the potential to reduce newborn antibiotic exposure but real world data from...
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SubjectTerms 692/699/255/1318
692/700/1720
Age
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antiinfectives and antibacterials
Birth
Birth weight
Blood
Care and treatment
Centers for Disease Control and Prevention (U.S.)
Childbirth & labor
Diagnosis
Disease control
Diseases
Dosage and administration
Drug therapy
Electronic health records
Female
Gestational age
Health aspects
Humans
Infant, Newborn
Infants
Infants (Newborn)
Male
Mathematical analysis
Medical records
Medicine
Medicine & Public Health
Membranes
Neonatal Sepsis - diagnosis
Neonatal Sepsis - drug therapy
Neonates
Neutrophils
Newborn babies
original-article
Pediatric Surgery
Pediatrics
Practice Guidelines as Topic
Retrospective Studies
Risk Factors
Sepsis
Tertiary Care Centers
Testing
United States
Title Impact of neonatal early-onset sepsis calculator on antibiotic use within two tertiary healthcare centers
URI https://link.springer.com/article/10.1038/jp.2016.236
https://www.ncbi.nlm.nih.gov/pubmed/28005063
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https://www.proquest.com/docview/2615531667
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https://www.proquest.com/docview/1891861688
Volume 37
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