miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

• Published in: Nature medicine Vol. 17; no. 12; pp. 1627 - 1635
• Main Authors: Mateescu, Bogdan, Batista, Luciana, Cardon, Melissa, Gruosso, Tina, de Feraudy, Yvan, Mariani, Odette, Nicolas, André, Meyniel, Jean-Philippe, Cottu, Paul, Sastre-Garau, Xavier, Mechta-Grigoriou, Fatima
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2011; Nature Publishing Group
• Subjects: 631/337/384/331; 692/420/755; 692/699/67/1517/1709; Adult; Aged; Aged, 80 and over; Animals; Antioxidants; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic - genetics; Down-Regulation; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Infectious Diseases; Metabolic Diseases; Mice; Mice, Nude; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Mitogen-Activated Protein Kinase 14 - genetics; Mitogen-Activated Protein Kinase 14 - metabolism; Molecular Medicine; Neoplasms, Glandular and Epithelial - genetics; Neoplasms, Glandular and Epithelial - pathology; Neurosciences; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Ovarian tumors; Oxidative Stress; Physiological aspects; Ribonucleic acid; RNA; Stress response; Tumors

This report identifies a new contribution of members of the miR-200 family to tumorigenesis. miR-200a and miR-141 specifically regulate p38α, contributing to the cellular modulation of oxidative stress responses. In this role, the miRs can accelerate ovarian tumorigenesis but also endow cancer cells...