A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD

• Published in: Scientific reports Vol. 10; no. 1; p. 13907
• Main Authors: Silveira, Sandra Cunha, Buhagiar-Labarchède, Géraldine, Onclercq-Delic, Rosine, Gemble, Simon, Bou Samra, Elias, Mameri, Hamza, Duchambon, Patricia, Machon, Christelle, Guitton, Jérôme, Amor-Guéret, Mounira
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.08.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/67; 631/80; Anaphase; Biochemistry, Molecular Biology; Biosynthesis; Cancer; Cellular Biology; Cytidine deaminase; Cytidine Deaminase - deficiency; Cytidine Deaminase - metabolism; Cytokines - antagonists & inhibitors; Cytokines - genetics; Cytokines - metabolism; Enzymes; Genes; Genomes; HeLa Cells; Humanities and Social Sciences; Humans; Life Sciences; Molecular biology; multidisciplinary; Mutants; Mutation - genetics; NAD; NAD - metabolism; Niacinamide - metabolism; Nicotinamide phosphoribosyltransferase; Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors; Nicotinamide Phosphoribosyltransferase - genetics; Nicotinamide Phosphoribosyltransferase - metabolism; Phosphoribosyltransferase; Poly (ADP-Ribose) Polymerase-1 - metabolism; Poly(ADP-ribose); Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerase 1; Proteins; Ribose; Science; Science (multidisciplinary)

Cytidine deaminase (CDA) deficiency causes pyrimidine pool disequilibrium. We previously reported that the excess cellular dC and dCTP resulting from CDA deficiency jeopardizes genome stability, decreasing basal poly(ADP-ribose) polymerase 1 (PARP-1) activity and increasing ultrafine anaphase bridge...