Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

• Published in: International journal of oncology Vol. 48; no. 1; pp. 45 - 54
• Main Authors: MUKAI, SHUNTARO, MORIYA, SHOTA, HIRAMOTO, MASAKI, KAZAMA, HIROMI, KOKUBA, HIROKO, CHE, XIAO-FANG, YOKOYAMA, TOMOHISA, SAKAMOTO, SATOSHI, SUGAWARA, AKIHIRO, SUNAZUKA, TOSHIAKI, ŌMURA, SATOSHI, HANDA, HIROSHI, ITOI, TAKAO, MIYAZAWA, KEISUKE
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.01.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Antibiotics; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy (Cytology); Autophagy - drug effects; Autophagy - genetics; Azithromycin - administration & dosage; Cancer therapies; Cell death; Cell Line, Tumor; Chemical industry; Chemotherapy; Clarithromycin - administration & dosage; Cytotoxicity; Development and progression; Drug Synergism; EGFR; Enzymes; ER stress; Erythromycin - administration & dosage; Erythromycin - analogs & derivatives; gefitinib; Gene Expression Regulation, Neoplastic - drug effects; Genetic aspects; Growth factors; Health aspects; Humans; Inhibitor drugs; Kinases; Leukemia; Lung cancer; Macrolide antibiotics; macrolides; Macrolides - administration & dosage; Medical prognosis; Metabolism; Mitochondria; Multiple myeloma; necroptosis; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Phosphorylation; Proteins; Quinazolines - administration & dosage; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - genetics; Regulation

Pancreatic cancer is one of the most difficult types of cancer to treat because of its high mortality rate due to chemotherapy resistance. We previously reported that combined treatment with gefitinib (GEF) and clarithromycin (CAM) results in enhanced cytotoxicity of GEF along with endoplasmic retic...