Quantifiable predictive features define epitope-specific T cell receptor repertoires

• Published in: Nature (London) Vol. 547; no. 7661; pp. 89 - 93
• Main Authors: Dash, Pradyot, Fiore-Gartland, Andrew J., Hertz, Tomer, Wang, George C., Sharma, Shalini, Souquette, Aisha, Crawford, Jeremy Chase, Clemens, E. Bridie, Nguyen, Thi H. O., Kedzierska, Katherine, La Gruta, Nicole L., Bradley, Philip, Thomas, Paul G.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.07.2017; Nature Publishing Group
• Subjects: 13/31; 38/77; 42/109; 45/23; 631/1647/48; 631/250/2152/2497; Algorithms; Amino acids; Animals; Antigens; CD8 antigen; CD8-Positive T-Lymphocytes - chemistry; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell receptors; Cluster Analysis; Conserved sequence; Epitopes; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Female; Genes; Histocompatibility; Humanities and Social Sciences; Humans; Immunology; letter; Lymphocytes; Lymphocytes T; Male; Mice; Mice, Inbred C57BL; multidisciplinary; Peptides; Physiological aspects; Receptors; Receptors, Antigen, T-Cell - chemistry; Receptors, Antigen, T-Cell - immunology; Receptors, Antigen, T-Cell, alpha-beta - chemistry; Receptors, Antigen, T-Cell, alpha-beta - immunology; Science; Sensitivity analysis; Substrate Specificity; T cell receptors; T cells; V(D)J Recombination

The authors characterize epitope-specific T cell repertoires, identify shared and recognizable features of TCRs, and develop tools to classify antigen specificity on the basis of sequence analysis. Defining T cell receptor repertoires In this study, Paul Thomas and colleagues use molecular genetic t...