Mesenchymal stem cell-based tissue regeneration therapies for periodontitis

• Published in: Regenerative therapy Vol. 14; pp. 72 - 78
• Main Authors: Ouchi, Takehito, Nakagawa, Taneaki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2020; Japanese Society for Regenerative Medicine; Elsevier
• Subjects: Mesenchymal stem cells; Periodontal tissue; Periodontitis; Pluripotent stem cells; Review; Tissue regeneration; BMMSCs; Tissue regeneration; iPSCs; PDGFRα; IFN-γ; MSCs; scRNA-seq; IGFBP-6; Periodontal tissue; PDL; Wnt; Mesenchymal stem cells; HERS; LepR; NCCs; BMP; FGF; iPSC-MSCs; Pluripotent stem cells; ECM; PDLSCs; C-MSCs; Periodontitis; TNF-α; GDF-5; DFSCs; PDLSCs, periodontal ligament stem cells; ECM, extracellular matrix; GDF-5, growth/differentiation factor-5; C-MSCs, clumps of MSC/ECM complexes; PDGFRα, platelet derived growth factor receptor α; IGFBP-6, insulin-like growth factor binding protein-6; HERS, Hertwig epithelial root sheath; iPSCs, induced pluripotent stem cells; PDL, periodontal ligament; BMP, bone morphogenetic protein; IFN-γ, interferon-gamma; TNF-α, tumor necrosis factor-alpha; FGF, fibroblast growth factor; scRNA-seq, single-cell RNA sequence; MSCs, mesenchymal stem cells; iPSC-MSCs, iPSC-derived MSCs; DFSCs, dental follicle stem cells; Wnt, wingless-INT; BMMSCs, bone marrow MSCs; LepR, leptin receptor; NCCs, neural crest cells

Periodontitis is commonly observed and is an important concern in dental health. It is characterized by a multifactorial etiology, including imbalance of oral microbiota, mechanical stress, and systemic diseases such as diabetes mellitus. The current standard treatments for periodontitis include eli...