Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor

• Published in: Thrombosis and haemostasis Vol. 94; no. 4; p. 831
• Main Authors: Ward, Jon R, Bingle, Lynne, Judge, Heather M, Brown, Simon B, Storey, Robert F, Whyte, Moira K B, Dower, Steven K, Buttle, David J, Sabroe, Ian
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2005
• Subjects: Adenosine Diphosphate - metabolism; Adenosine Diphosphate - pharmacology; Antibodies; Atherosclerosis - metabolism; Blood Platelets - metabolism; Calcium - metabolism; Cell Line; Epinephrine - pharmacology; Humans; Lipopolysaccharides - pharmacology; Lipoproteins - pharmacology; Megakaryocytes - cytology; P-Selectin - metabolism; Platelet Activating Factor - metabolism; Platelet Activating Factor - pharmacology; Platelet Activation - drug effects; Platelet Membrane Glycoprotein IIb - immunology; Platelet Membrane Glycoprotein IIb - metabolism; Toll-Like Receptor 2 - agonists; Toll-Like Receptor 2 - immunology; Toll-Like Receptor 2 - metabolism; Toll-Like Receptor 4 - agonists; Toll-Like Receptor 4 - immunology; Toll-Like Receptor 4 - metabolism; Vasoconstrictor Agents - pharmacology

Inappropriate platelet activation is a feature of acute and chronic diseases such as disseminated intravascular coagulation (DIC) and atherosclerosis. Since proinflammatory microbial-derived agonists can be involved in the pathogenesis of these diseases, we examined the potential role of TLR4 (media...