Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment

• Published in: Journal of neuropathology and experimental neurology Vol. 68; no. 12; pp. 1309 - 1318
• Main Authors: Bruno, Martin A., Mufson, Elliott J., Wuu, Joanne, Cuello, A. Claudio
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Association of Neuropathologists, Inc 01.12.2009; Lippincott Williams & Wilkins; Oxford University Press
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - enzymology; Alzheimer Disease - pathology; Biological and medical sciences; Brain - enzymology; Cognition Disorders - enzymology; Cognition Disorders - pathology; Disease Progression; Female; Humans; Male; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Medical sciences; Nerve Growth Factor - metabolism; Nervous system involvement in other diseases. Miscellaneous; Neurology; Neuropsychological Tests; Nervous system diseases; Cognitive disorder; Matrix metalloproteinase 9; Enzyme; Alzheimer disease; Nerve growth factor precursor; Nerve growth factor; Metalloendopeptidases; Cognition; Precursor; Cerebral disorder; Peptidases; Central nervous system disease; Hydrolases; Degenerative disease; mild cognitive impairment

Nerve growth factor (NGF)-dependent cholinergic basal forebrain neurons degenerate during the progression of Alzheimer disease (AD). Elevated proNGF and reduced levels of the TrkA high-affinity NGF receptor occur in prodromal and advanced stages of AD. We recently described a protease cascade respon...