Influenza A Virus Infection in Domestic Ferrets
Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, a survey was performed to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. Using enzyme-linked immunosorbent...
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| Published in | Japanese Journal of Infectious Diseases Vol. 75; no. 3; pp. 325 - 327 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
31.05.2022
Japan Science and Technology Agency |
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| Abstract | Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, a survey was performed to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. Using enzyme-linked immunosorbent assay for hemagglutinin proteins, we found a high positive rate for the H1 (24.1%) and H3 (5.2%) subtypes. The results were confirmed by a virus neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory disease and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid to IAV infection from humans to ferrets and vice versa. |
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| AbstractList | Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, a survey was performed to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. Using enzyme-linked immunosorbent assay for hemagglutinin proteins, we found a high positive rate for the H1 (24.1%) and H3 (5.2%) subtypes. The results were confirmed by a virus neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory disease and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid to IAV infection from humans to ferrets and vice versa. Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, a survey was performed to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. Using enzyme-linked immunosorbent assay for hemagglutinin proteins, we found a high positive rate for the H1 (24.1%) and H3 (5.2%) subtypes. The results were confirmed by a virus neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory disease and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid to IAV infection from humans to ferrets and vice versa.Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, a survey was performed to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. Using enzyme-linked immunosorbent assay for hemagglutinin proteins, we found a high positive rate for the H1 (24.1%) and H3 (5.2%) subtypes. The results were confirmed by a virus neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory disease and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid to IAV infection from humans to ferrets and vice versa. |
| ArticleNumber | JJID.2021.745 |
| Author | Kuroda, Yudai Miwa, Yasutsugu Okada, Ai Watamori, Akiko Ishida, Hiroho Horimoto, Taisuke Murakami, Shin Maeda, Ken Shimoda, Hiroshi Takada, Ayato |
| Author_xml | – sequence: 1 fullname: Kuroda, Yudai organization: Department of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Japan – sequence: 2 fullname: Okada, Ai organization: Department of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Japan – sequence: 3 fullname: Shimoda, Hiroshi organization: Department of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Japan – sequence: 4 fullname: Miwa, Yasutsugu organization: Miwa Exotic Animal Hospital, Japan – sequence: 5 fullname: Watamori, Akiko organization: Miwa Exotic Animal Hospital, Japan – sequence: 6 fullname: Ishida, Hiroho organization: Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan – sequence: 7 fullname: Murakami, Shin organization: Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan – sequence: 8 fullname: Takada, Ayato organization: Global Institution for Collaborative Research and Education, Global Station for Zoonosis Control, Hokkaido University, Japan – sequence: 9 fullname: Horimoto, Taisuke organization: Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan – sequence: 10 fullname: Maeda, Ken organization: Department of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Japan |
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| Cites_doi | 10.1128/JCM.43.8.4139-4146.2005 10.3201/eid2312.170798 10.1016/j.jviromet.2016.07.030 10.3201/eid2002.130543 10.1128/mBio.00909-18 10.1007/s12250-015-3580-9 10.2174/1876518101002020015 10.1292/jvms.16-0059 10.3390/ijms18081650 |
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| References | 8. Minami S, Terada Y, Shimoda H, et al. Establishment of serological test to detect antibody against ferret coronavirus. J Vet Med Sci. 2016;78:1013-1017. 10. Hatakeyama S, Sakai-Tagawa Y, Kiso M, et al. Enhanced expression of an alpha 2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor. J Clin Microbiol. 2005;43:4139-4146. 6. Yonemitsu K, Terada Y, Kuwata R, et al. Simple and specific method for detection of antibodies against hepatitis E virus in mammalian species. J Virol Methods. 2016;238:56-61. 2. Chen Y, Trovão NS, Wang G, et al. Emergence and evolution of novel reassortant influenza A viruses in canines in Southern China. mBio. 2018;9:e00909-18. 3. Horimoto T, Gen F, Murakami S, et al. Cats as a potential source of emerging influenza virus infections. Virol Sin. 2015;30:221-223. 4. Marinova-Petkova A, Laplante J, Jang Y, et al. Avian influenza A(H7N2) virus in human exposed to sick cats, New York, USA, 2016. Emerg Infect Dis. 2017;23:2046-2049. 7. Terada Y, Minami S, Noguchi K, et al. Genetic characterization of coronaviruses from domestic ferrets, Japan. Emerg Infect Dis. 2014;20:284-287. 9. Nakamura K, Fujisaki S, Shirakura M, et al. Manual for the detection of pathogen influenza virus Ver.4. Available at <https://www.niid.go.jp/niid/images/lab-manual/influenza20190116.pdf>. Accessed May 26, 2021. Japanese. 1. Shao W, Li X, Goraya MU, et al. Evolution of influenza A virus by mutation and re-assortment. Int J Mol Sci. 2017;18:1650. 5. Haga T, Horimoto T. Animal models to study influenza virus pathogenesis and control. Open Antimicrob Agents J. 2010;2:15-21. 1 2 3 4 5 6 7 8 9 10 |
| References_xml | – reference: 3. Horimoto T, Gen F, Murakami S, et al. Cats as a potential source of emerging influenza virus infections. Virol Sin. 2015;30:221-223. – reference: 10. Hatakeyama S, Sakai-Tagawa Y, Kiso M, et al. Enhanced expression of an alpha 2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor. J Clin Microbiol. 2005;43:4139-4146. – reference: 7. Terada Y, Minami S, Noguchi K, et al. Genetic characterization of coronaviruses from domestic ferrets, Japan. Emerg Infect Dis. 2014;20:284-287. – reference: 8. Minami S, Terada Y, Shimoda H, et al. Establishment of serological test to detect antibody against ferret coronavirus. J Vet Med Sci. 2016;78:1013-1017. – reference: 9. Nakamura K, Fujisaki S, Shirakura M, et al. Manual for the detection of pathogen influenza virus Ver.4. Available at <https://www.niid.go.jp/niid/images/lab-manual/influenza20190116.pdf>. Accessed May 26, 2021. Japanese. – reference: 1. Shao W, Li X, Goraya MU, et al. Evolution of influenza A virus by mutation and re-assortment. Int J Mol Sci. 2017;18:1650. – reference: 5. Haga T, Horimoto T. Animal models to study influenza virus pathogenesis and control. Open Antimicrob Agents J. 2010;2:15-21. – reference: 4. Marinova-Petkova A, Laplante J, Jang Y, et al. Avian influenza A(H7N2) virus in human exposed to sick cats, New York, USA, 2016. Emerg Infect Dis. 2017;23:2046-2049. – reference: 2. Chen Y, Trovão NS, Wang G, et al. Emergence and evolution of novel reassortant influenza A viruses in canines in Southern China. mBio. 2018;9:e00909-18. – reference: 6. Yonemitsu K, Terada Y, Kuwata R, et al. Simple and specific method for detection of antibodies against hepatitis E virus in mammalian species. J Virol Methods. 2016;238:56-61. – ident: 10 doi: 10.1128/JCM.43.8.4139-4146.2005 – ident: 4 doi: 10.3201/eid2312.170798 – ident: 6 doi: 10.1016/j.jviromet.2016.07.030 – ident: 7 doi: 10.3201/eid2002.130543 – ident: 2 doi: 10.1128/mBio.00909-18 – ident: 3 doi: 10.1007/s12250-015-3580-9 – ident: 9 – ident: 5 doi: 10.2174/1876518101002020015 – ident: 8 doi: 10.1292/jvms.16-0059 – ident: 1 doi: 10.3390/ijms18081650 |
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| Title | Influenza A Virus Infection in Domestic Ferrets |
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