Successful Treatment of Mepolizumab- and Prednisolone-resistant Allergic Bronchopulmonary Aspergillosis with Dupilumab

• Published in: Internal Medicine Vol. 60; no. 17; pp. 2839 - 2842
• Main Authors: Mikura, Sunao, Saraya, Takeshi, Yoshida, Yuki, Oda, Miku, Ishida, Manabu, Honda, Kojiro, Nakamoto, Keitaro, Tamura, Masaki, Takata, Saori, Shimoyamada, Hiroaki, Fujiwara, Masachika, Ishii, Haruyuki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.09.2021; Japan Science and Technology Agency
• Subjects: Allergic bronchopulmonary aspergillosis; Aspergillosis; Case Report; Corticosteroids; dupilumab; Injection; Interleukin 13; Interleukin 4; Interleukin 5; Internal medicine; Itraconazole; mepolizumab; Prednisolone; prednisolone; allergic bronchopulmonary aspergillosis; mepolizumab; dupilumab

A 45-year-old man with allergic bronchopulmonary aspergillosis (ABPA) was treated with oral prednisolone (PSL) (30 mg/day), inhaled corticosteroids, and long-acting beta2-agonists. After confirmation of a PSL-dependent status (8 mg/day), subcutaneous injection with anti-interleukin (IL)-5 antibody (...