Elevated immune response in the brain of autistic patients

• Published in: Journal of neuroimmunology Vol. 207; no. 1; pp. 111 - 116
• Main Authors: Li, Xiaohong, Chauhan, Abha, Sheikh, Ashfaq M., Patil, Sangita, Chauhan, Ved, Li, Xiu-Min, Ji, Lina, Brown, Ted, Malik, Mazhar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.02.2009
• Subjects: Adolescent; Adult; Allergy and Immunology; Autistic Disorder - immunology; Autistic Disorder - pathology; Autistic spectrum disorders (ASD); Brain - immunology; Brain - pathology; Case-Control Studies; Chemokines - metabolism; Child; Child, Preschool; Cytokines; Cytokines - metabolism; Female; Flow cytometry method; Humans; Immune response; Inflammation; Male; Multiplexed bead analysis; Neurology; Statistics, Nonparametric; Th1 Cells - immunology; Th2 Cells - immunology; Young Adult; Multiplexed bead analysis; Inflammation; Immune response; Cytokines; Flow cytometry method; Autistic spectrum disorders (ASD)

This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-α, IL-6 and GM-CSF), Th1 cytokine (IFN-γ) and chemokine (IL-8) were significantly increased in the brain...