Elevated immune response in the brain of autistic patients
This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-α, IL-6 and GM-CSF), Th1 cytokine (IFN-γ) and chemokine (IL-8) were significantly increased in the brain...
Saved in:
| Published in | Journal of neuroimmunology Vol. 207; no. 1; pp. 111 - 116 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
15.02.2009
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-α, IL-6 and GM-CSF), Th1 cytokine (IFN-γ) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. |
|---|---|
| AbstractList | Abstract This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-α, IL-6 and GM-CSF), Th1 cytokine (IFN-γ) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients.UNLABELLEDThis study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients.ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD.CONCLUSIONASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-α, IL-6 and GM-CSF), Th1 cytokine (IFN-γ) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF- alpha , IL-6 and GM-CSF), Th1 cytokine (IFN- gamma ) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. |
| Author | Li, Xiaohong Ji, Lina Sheikh, Ashfaq M. Chauhan, Abha Brown, Ted Patil, Sangita Chauhan, Ved Li, Xiu-Min Malik, Mazhar |
| AuthorAffiliation | b Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 a Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314 |
| AuthorAffiliation_xml | – name: a Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314 – name: b Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 |
| Author_xml | – sequence: 1 givenname: Xiaohong surname: Li fullname: Li, Xiaohong email: xiaohong.li@mssm.edu organization: Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, United States – sequence: 2 givenname: Abha surname: Chauhan fullname: Chauhan, Abha organization: Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, United States – sequence: 3 givenname: Ashfaq M. surname: Sheikh fullname: Sheikh, Ashfaq M. organization: Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, United States – sequence: 4 givenname: Sangita surname: Patil fullname: Patil, Sangita organization: Department of Pediatrics, Mount Sinai School of Medicine, NY 10029, New York, United States – sequence: 5 givenname: Ved surname: Chauhan fullname: Chauhan, Ved organization: Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, United States – sequence: 6 givenname: Xiu-Min surname: Li fullname: Li, Xiu-Min organization: Department of Pediatrics, Mount Sinai School of Medicine, NY 10029, New York, United States – sequence: 7 givenname: Lina surname: Ji fullname: Ji, Lina organization: Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, United States – sequence: 8 givenname: Ted surname: Brown fullname: Brown, Ted organization: Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, United States – sequence: 9 givenname: Mazhar surname: Malik fullname: Malik, Mazhar organization: Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19157572$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUsFu1DAQtVAR3RZ-ocqJ26ZjJ3EShCqqqhSkShyA88jrTKhDYi-2s1L_HkfbVtADy2lGmvfePM2bE3ZknSXGzjjkHLg8H_LB0uydmXIB0ORc5ADiBVvxphbrphT8iK0SsFpXtWiO2UkIAwCvirJ9xY55y6s6DVbs3fVIOxWpy8w0zZYyT2HrbKDM2CzeUbbxKnWuz9QcTYhGZ1sVDdkYXrOXvRoDvXmop-z7x-tvV5_Wt19uPl9d3q615BDXuqhkIaBqu74gXWwq0UmoO05dIVJDha7bppK9kgm-EdTWneoTqOJlX3MNxSm72Otu581EnU67vRpx682k_D06ZfDviTV3-MPtUNQ1CNkkgbcPAt79milEnEzQNI7KkpsDStmWTdvIg0ABhYQWeAKe_WnpycvjXRPg_R6gvQvBU4_axHQ3tzg0I3LAJUYc8DFGXGJELjDFmOjyGf1pwyHihz2RUiA7Qx6DTmFp6ownHbFz5rDExTMJPRprtBp_0j2Fwc3epriRY0gE_Lo82fJj0ACULch_C_yPg9_lreYE |
| CitedBy_id | crossref_primary_10_1038_mp_2016_77 crossref_primary_10_12677_IJPN_2014_33003 crossref_primary_10_1016_j_neuint_2016_12_005 crossref_primary_10_1007_s00213_013_3200_z crossref_primary_10_3390_ijms242216218 crossref_primary_10_1016_j_bbi_2013_12_004 crossref_primary_10_1016_j_ejphar_2018_04_008 crossref_primary_10_2174_1389203721999200820165117 crossref_primary_10_3389_fncel_2021_748136 crossref_primary_10_1016_j_bbi_2018_06_011 crossref_primary_10_1016_j_nbd_2019_104483 crossref_primary_10_1038_s41390_020_0910_x crossref_primary_10_3389_fnins_2015_00172 crossref_primary_10_1080_15622975_2018_1523561 crossref_primary_10_1016_j_brainres_2012_03_036 crossref_primary_10_1016_j_jneuroim_2014_12_003 crossref_primary_10_1016_j_jneuroim_2013_02_019 crossref_primary_10_1016_j_bbi_2016_02_010 crossref_primary_10_1016_j_bbih_2020_100069 crossref_primary_10_3390_brainsci12020220 crossref_primary_10_1186_2047_9158_2_17 crossref_primary_10_1371_journal_pone_0056927 crossref_primary_10_3389_fncel_2015_00519 crossref_primary_10_1038_mp_2011_165 crossref_primary_10_2174_0126660822262191231024081805 crossref_primary_10_1038_s41392_022_01081_0 crossref_primary_10_3390_ijms18071425 crossref_primary_10_1016_j_biopsych_2010_05_024 crossref_primary_10_1586_eci_10_18 crossref_primary_10_1016_j_rasd_2014_10_012 crossref_primary_10_1016_j_mcn_2012_10_003 crossref_primary_10_1038_nrn3978 crossref_primary_10_1016_j_jsps_2023_101921 crossref_primary_10_1007_s00115_016_0172_3 crossref_primary_10_2478_s13380_011_0016_3 crossref_primary_10_1038_s41576_018_0066_2 crossref_primary_10_3389_fpsyt_2019_00440 crossref_primary_10_1016_j_jneuroim_2023_578253 crossref_primary_10_1186_s13229_017_0161_9 crossref_primary_10_3389_fpsyt_2019_00647 crossref_primary_10_1016_j_brainresbull_2019_07_006 crossref_primary_10_3389_fimmu_2022_816619 crossref_primary_10_1038_s41593_024_01636_0 crossref_primary_10_1186_s12974_015_0466_6 crossref_primary_10_1016_j_bbr_2017_04_038 crossref_primary_10_1002_dneu_20969 crossref_primary_10_3389_fncel_2018_00256 crossref_primary_10_1016_j_jtemb_2016_06_002 crossref_primary_10_1016_j_bbih_2021_100267 crossref_primary_10_1016_j_micron_2019_102732 crossref_primary_10_1155_2011_307152 crossref_primary_10_3389_fpsyt_2022_821455 crossref_primary_10_1016_j_yebeh_2010_12_027 crossref_primary_10_4137_BMI_S21946 crossref_primary_10_1016_j_bbr_2021_113538 crossref_primary_10_3390_ijms241411710 crossref_primary_10_3389_fnins_2022_999346 crossref_primary_10_1007_s00431_013_2183_4 crossref_primary_10_1016_j_imbio_2010_03_001 crossref_primary_10_3349_ymj_2023_0362 crossref_primary_10_1016_j_neubiorev_2015_05_013 crossref_primary_10_1016_j_neuint_2019_03_009 crossref_primary_10_1007_s12035_024_03940_z crossref_primary_10_1073_pnas_2004666117 crossref_primary_10_1186_s13073_018_0576_8 crossref_primary_10_17816_MAJ63228 crossref_primary_10_1097_WCO_0b013e328336a01f crossref_primary_10_1016_j_cellsig_2018_09_006 crossref_primary_10_3389_fnins_2021_680214 crossref_primary_10_1016_j_physbeh_2023_114264 crossref_primary_10_1080_15569543_2020_1747495 crossref_primary_10_1007_s12031_021_01912_9 crossref_primary_10_5765_jkacap_200013 crossref_primary_10_1002_2211_5463_13889 crossref_primary_10_3390_ijms231911077 crossref_primary_10_1097_FBP_0000000000000428 crossref_primary_10_1016_j_jpsychires_2022_12_032 crossref_primary_10_1038_s41380_022_01566_y crossref_primary_10_1177_039463201202500201 crossref_primary_10_1016_j_intimp_2018_10_027 crossref_primary_10_1016_j_pbb_2022_173408 crossref_primary_10_1203_PDR_0b013e318212f16b crossref_primary_10_1016_j_biopha_2022_112688 crossref_primary_10_1016_j_pnpbp_2025_111275 crossref_primary_10_1016_j_ejphar_2011_07_013 crossref_primary_10_1007_s12311_012_0355_9 crossref_primary_10_1016_j_jaac_2013_11_013 crossref_primary_10_3389_fpsyt_2023_1086068 crossref_primary_10_1038_mp_2010_136 crossref_primary_10_1002_aur_2205 crossref_primary_10_1155_2016_9060751 crossref_primary_10_4103_1673_5374_310608 crossref_primary_10_1007_s11011_018_0206_6 crossref_primary_10_1007_s11481_024_10111_3 crossref_primary_10_1016_j_mehy_2013_04_002 crossref_primary_10_1016_j_mehy_2019_02_042 crossref_primary_10_1002_prca_201700085 crossref_primary_10_1016_j_bbi_2012_12_021 crossref_primary_10_1016_j_jneuroim_2019_577066 crossref_primary_10_1016_j_eplepsyres_2023_107114 crossref_primary_10_1371_journal_pone_0020912 crossref_primary_10_3389_fped_2018_00394 crossref_primary_10_1016_j_bbi_2011_08_007 crossref_primary_10_1177_039463200902200401 crossref_primary_10_1016_j_molimm_2018_12_020 crossref_primary_10_1073_pnas_1604992113 crossref_primary_10_1007_s00213_018_5120_4 crossref_primary_10_1016_j_mcn_2017_04_012 crossref_primary_10_1016_j_neuint_2016_12_012 crossref_primary_10_1111_pai_12149 crossref_primary_10_3389_fimmu_2023_1124356 crossref_primary_10_1371_journal_pone_0132542 crossref_primary_10_1007_s12017_018_8483_0 crossref_primary_10_1016_j_jpsychires_2020_07_013 crossref_primary_10_3389_fnut_2022_940841 crossref_primary_10_1007_s00213_019_05280_6 crossref_primary_10_1007_s10803_009_0903_4 crossref_primary_10_1007_s11427_015_4941_1 crossref_primary_10_1016_j_rasd_2020_101707 crossref_primary_10_3390_ph17070831 crossref_primary_10_1186_1742_2094_9_74 crossref_primary_10_1007_s12035_016_0066_1 crossref_primary_10_3389_fimmu_2018_00068 crossref_primary_10_1016_j_tips_2025_02_004 crossref_primary_10_1177_1073858414536468 crossref_primary_10_1016_j_rasd_2010_03_009 crossref_primary_10_1016_j_neuroscience_2017_01_033 crossref_primary_10_1590_S1676_26492012000300005 crossref_primary_10_1073_pnas_1906817116 crossref_primary_10_1016_j_envres_2016_11_022 crossref_primary_10_4137_BMI_S11270 crossref_primary_10_1016_j_bbi_2009_08_001 crossref_primary_10_1186_s12974_014_0189_0 crossref_primary_10_1016_j_bbi_2021_07_004 crossref_primary_10_1186_s12951_025_03250_z crossref_primary_10_4137_JCNSD_S13767 crossref_primary_10_1186_1742_2094_8_52 crossref_primary_10_1186_1742_2094_7_80 crossref_primary_10_1002_jdn_10221 crossref_primary_10_1176_appi_focus_24022004 crossref_primary_10_3389_fped_2014_00123 crossref_primary_10_1016_j_neuroscience_2014_10_011 crossref_primary_10_2174_1871527319666200628015039 crossref_primary_10_1155_2012_205362 crossref_primary_10_1016_j_jnutbio_2019_05_002 crossref_primary_10_1016_j_biopsych_2018_06_014 crossref_primary_10_1016_j_spen_2020_100836 crossref_primary_10_1016_j_lfs_2017_12_027 crossref_primary_10_1002_glia_23263 crossref_primary_10_1212_WNL_0b013e3182166dc7 crossref_primary_10_1016_j_reprotox_2024_108599 crossref_primary_10_1016_j_neuroscience_2013_08_025 crossref_primary_10_1016_j_scitotenv_2015_07_024 crossref_primary_10_1016_j_neulet_2011_08_053 crossref_primary_10_1007_s11481_023_10089_4 crossref_primary_10_1111_jnc_15141 crossref_primary_10_3390_toxics10070379 crossref_primary_10_1016_j_neuro_2022_06_007 crossref_primary_10_1016_j_pnpbp_2009_12_020 crossref_primary_10_3389_fimmu_2021_676255 crossref_primary_10_9758_cpn_2018_16_3_246 crossref_primary_10_1007_s12035_015_9178_2 crossref_primary_10_4252_wjsc_v11_i2_55 crossref_primary_10_1002_14651858_CD010922_pub2 crossref_primary_10_3389_fncel_2018_00405 crossref_primary_10_3390_cells9102176 crossref_primary_10_1016_j_pnpbp_2018_04_011 crossref_primary_10_1016_j_reprotox_2024_108582 crossref_primary_10_1089_cap_2010_0134 crossref_primary_10_1016_j_neulet_2024_137710 crossref_primary_10_3389_fpsyt_2021_775017 crossref_primary_10_1016_j_pnpbp_2020_110173 crossref_primary_10_1097_WCO_0b013e328338cade crossref_primary_10_1002_jat_4382 crossref_primary_10_1016_j_bbi_2011_02_011 crossref_primary_10_3109_15622975_2015_1067372 crossref_primary_10_3390_ijms21093293 crossref_primary_10_1186_s12974_024_03106_7 crossref_primary_10_3389_fpsyt_2015_00121 crossref_primary_10_1016_j_jaut_2015_11_003 crossref_primary_10_1016_j_ynstr_2019_100174 crossref_primary_10_1093_cercor_bhad451 crossref_primary_10_1016_j_pneurobio_2017_05_003 crossref_primary_10_1080_20473869_2024_2366722 crossref_primary_10_1016_j_jneuroim_2017_08_002 crossref_primary_10_1038_nrn_2017_39 crossref_primary_10_1016_j_psychres_2024_116245 crossref_primary_10_1016_j_pnpbp_2020_110185 crossref_primary_10_3390_bs4020125 crossref_primary_10_1186_1866_1955_5_9 crossref_primary_10_1186_s13229_024_00589_2 crossref_primary_10_2217_bmm_14_39 crossref_primary_10_3390_molecules24142640 crossref_primary_10_1017_S0140525X18002790 crossref_primary_10_3390_md19040201 crossref_primary_10_3390_e15010372 crossref_primary_10_3390_ph7121028 crossref_primary_10_3389_fnagi_2022_868448 crossref_primary_10_1016_j_envint_2022_107121 crossref_primary_10_3390_brainsci10100747 crossref_primary_10_1016_j_bbi_2022_01_015 crossref_primary_10_1016_j_mehy_2014_09_005 crossref_primary_10_1016_j_neubiorev_2021_06_043 crossref_primary_10_1371_journal_pone_0094968 crossref_primary_10_1002_ptr_8101 crossref_primary_10_1155_2011_785265 crossref_primary_10_1016_j_bbr_2023_114384 crossref_primary_10_1016_j_lfs_2019_116930 crossref_primary_10_1016_j_neuint_2021_105122 crossref_primary_10_1016_j_neuro_2020_10_014 crossref_primary_10_1016_j_clinthera_2013_04_009 crossref_primary_10_3389_fpsyt_2018_00543 crossref_primary_10_1007_s11920_012_0326_3 crossref_primary_10_1186_s12974_014_0156_9 crossref_primary_10_1007_s00018_021_04052_w crossref_primary_10_1016_j_rasd_2012_08_007 crossref_primary_10_1177_10738584241252576 crossref_primary_10_1038_s41598_024_65392_8 crossref_primary_10_1038_cddis_2014_227 crossref_primary_10_3390_brainsci10050309 crossref_primary_10_1007_s12017_018_8488_8 crossref_primary_10_1038_s41598_017_19035_w crossref_primary_10_3389_fimmu_2017_00011 crossref_primary_10_3389_fpsyt_2019_00849 crossref_primary_10_3389_fncel_2016_00021 crossref_primary_10_3390_cells12071087 crossref_primary_10_3389_fpsyt_2018_00751 crossref_primary_10_3390_ijms231911013 crossref_primary_10_1016_j_neuroscience_2023_08_028 crossref_primary_10_1016_j_imlet_2014_11_006 crossref_primary_10_1016_j_ejphar_2019_01_016 crossref_primary_10_2147_NDT_S251394 crossref_primary_10_3390_cells13131095 crossref_primary_10_1016_j_eplepsyres_2018_05_009 crossref_primary_10_1016_j_yfrne_2014_03_006 crossref_primary_10_1038_tp_2016_77 crossref_primary_10_1517_14656560903107789 crossref_primary_10_1016_j_bbi_2023_03_015 crossref_primary_10_3389_fncel_2017_00120 crossref_primary_10_1159_000495660 crossref_primary_10_1038_s41398_018_0093_y crossref_primary_10_1186_s13229_016_0115_7 crossref_primary_10_1016_j_psychres_2022_114735 crossref_primary_10_1186_1742_2094_7_48 crossref_primary_10_1016_j_bbr_2017_05_013 crossref_primary_10_1186_s13041_020_00635_z crossref_primary_10_1016_j_biopsych_2012_05_004 crossref_primary_10_1038_s41398_021_01766_0 crossref_primary_10_1016_j_taap_2010_12_003 crossref_primary_10_1016_j_brainresbull_2021_05_024 crossref_primary_10_1016_j_lfs_2015_02_027 crossref_primary_10_1186_s12916_015_0310_y crossref_primary_10_1016_j_neuroscience_2009_10_035 crossref_primary_10_1186_1476_069X_12_41 crossref_primary_10_3389_fnins_2016_00609 crossref_primary_10_3390_antiox13111390 crossref_primary_10_1016_j_bbi_2014_06_006 crossref_primary_10_1016_j_biopsycho_2018_12_008 crossref_primary_10_3390_ijms20092283 crossref_primary_10_1016_j_gene_2012_01_020 crossref_primary_10_1016_j_ajog_2019_06_013 crossref_primary_10_1179_2047387713Y_0000000029 crossref_primary_10_1155_2021_7413605 crossref_primary_10_3390_neurosci2020015 crossref_primary_10_1017_S1092852919001603 crossref_primary_10_3390_brainsci11020249 crossref_primary_10_1007_s10661_016_5405_1 crossref_primary_10_4315_0362_028X_JFP_15_587 crossref_primary_10_3390_life13081736 crossref_primary_10_1002_aur_1940 crossref_primary_10_3390_antiox9121186 crossref_primary_10_18632_oncotarget_19326 crossref_primary_10_1016_j_imlet_2021_01_007 crossref_primary_10_1111_bcpt_12154 crossref_primary_10_1155_2014_491316 crossref_primary_10_3390_ijms20153611 crossref_primary_10_1134_S0006297923030021 crossref_primary_10_7717_peerj_12630 crossref_primary_10_1016_j_physbeh_2019_112776 crossref_primary_10_1111_nyas_13864 crossref_primary_10_1016_j_bbi_2018_09_003 crossref_primary_10_1016_j_cca_2019_12_009 crossref_primary_10_3389_fnins_2016_00396 crossref_primary_10_1007_s12031_023_02179_y crossref_primary_10_1016_j_bbi_2025_02_002 crossref_primary_10_31857_S0320972523030028 crossref_primary_10_1016_j_tics_2018_04_006 crossref_primary_10_1016_j_lfs_2015_09_012 crossref_primary_10_3390_brainsci12081041 crossref_primary_10_1016_j_jaac_2019_03_014 crossref_primary_10_3390_ijms22083972 crossref_primary_10_3389_fnmol_2022_1009662 crossref_primary_10_3389_fpsyt_2020_561998 crossref_primary_10_1016_j_neuropharm_2024_109890 crossref_primary_10_1186_s12887_024_05182_3 crossref_primary_10_1016_j_neuropharm_2014_10_023 crossref_primary_10_1186_s12974_017_0938_y crossref_primary_10_1186_s13229_015_0061_9 crossref_primary_10_1089_neu_2023_0135 crossref_primary_10_3389_fimmu_2023_1100816 crossref_primary_10_3390_ht8020010 crossref_primary_10_1016_j_bbi_2010_09_002 crossref_primary_10_3390_ijms23073894 crossref_primary_10_3390_jcm11102725 crossref_primary_10_1007_s12035_017_0548_9 crossref_primary_10_18863_pgy_1189139 crossref_primary_10_1111_pcn_13016 crossref_primary_10_3390_nu12030661 crossref_primary_10_3390_nu14071497 crossref_primary_10_3390_cells12242827 crossref_primary_10_1080_14728222_2018_1515917 crossref_primary_10_3389_fcell_2022_809686 crossref_primary_10_3390_ijms24065487 crossref_primary_10_1002_ajmg_b_32511 crossref_primary_10_1242_bio_041327 crossref_primary_10_3389_fpsyt_2021_670200 crossref_primary_10_1016_j_imlet_2022_03_001 crossref_primary_10_1007_s10803_021_05271_7 crossref_primary_10_1007_s10803_012_1513_0 crossref_primary_10_1016_j_neubiorev_2020_12_009 crossref_primary_10_1016_j_nsa_2024_104071 crossref_primary_10_1016_j_eplepsyres_2011_03_004 crossref_primary_10_1016_j_neuint_2017_02_014 crossref_primary_10_12965_jer_1632696_348 crossref_primary_10_1017_neu_2019_18 crossref_primary_10_3390_ijms22010118 crossref_primary_10_3109_15622975_2011_639803 crossref_primary_10_1002_aur_1906 crossref_primary_10_1016_j_neuro_2015_12_014 crossref_primary_10_1016_j_braindev_2013_04_015 crossref_primary_10_3390_biom13101549 crossref_primary_10_1177_07487304231178950 crossref_primary_10_1007_s12264_017_0103_8 crossref_primary_10_3389_fnins_2016_00463 crossref_primary_10_2174_1381612825666191205091312 crossref_primary_10_1007_s11011_019_00510_4 crossref_primary_10_1016_j_ejphar_2015_03_086 crossref_primary_10_1016_j_jcmgh_2016_11_008 crossref_primary_10_3389_fpsyt_2022_842755 crossref_primary_10_3390_cells11152419 crossref_primary_10_1586_egh_11_46 crossref_primary_10_1038_s41590_024_01797_x crossref_primary_10_1016_j_brainresbull_2018_08_020 crossref_primary_10_1007_s43939_024_00133_2 crossref_primary_10_3390_ijms21114097 crossref_primary_10_3389_fnut_2022_957600 crossref_primary_10_1186_s12974_016_0575_x crossref_primary_10_3109_1547691X_2012_682663 crossref_primary_10_1038_s41398_020_0845_3 crossref_primary_10_1038_s41398_022_01987_x crossref_primary_10_1002_dev_21803 crossref_primary_10_1111_ejn_13028 crossref_primary_10_1155_2017_4314025 crossref_primary_10_3389_fimmu_2019_01474 crossref_primary_10_1016_j_ntt_2012_07_006 crossref_primary_10_1016_j_mehy_2009_08_033 crossref_primary_10_1124_jpet_116_234476 crossref_primary_10_1016_j_pnpbp_2017_08_002 crossref_primary_10_1016_j_gendis_2020_07_002 crossref_primary_10_3390_biomedicines12071402 crossref_primary_10_1517_14728222_2011_571212 crossref_primary_10_1007_s10803_013_1859_y crossref_primary_10_1002_mco2_497 crossref_primary_10_3390_brainsci13111519 crossref_primary_10_31083_j_fbe1401001 crossref_primary_10_1016_j_neubiorev_2021_07_023 crossref_primary_10_1016_j_envint_2018_10_026 crossref_primary_10_1186_1471_2431_12_89 crossref_primary_10_1016_j_jneuroim_2020_577167 crossref_primary_10_1038_s41398_022_02149_9 crossref_primary_10_3390_ph17101293 crossref_primary_10_1111_j_1601_183X_2011_00702_x crossref_primary_10_1111_jnc_12087 crossref_primary_10_3390_jpm11010041 crossref_primary_10_1186_1742_2094_9_223 crossref_primary_10_1016_j_neubiorev_2017_05_001 crossref_primary_10_1007_s12640_013_9393_4 crossref_primary_10_1007_s10803_013_1824_9 crossref_primary_10_1007_s12035_020_01976_5 crossref_primary_10_1080_19490976_2019_1662260 crossref_primary_10_4137_CMPed_S38337 crossref_primary_10_1016_j_toxrep_2019_10_019 crossref_primary_10_1016_j_mcn_2015_11_009 crossref_primary_10_1371_journal_pone_0020470 crossref_primary_10_1016_j_bbi_2012_05_005 crossref_primary_10_3390_ph15020161 crossref_primary_10_1016_j_rasd_2019_101500 crossref_primary_10_1017_S1740925X12000142 crossref_primary_10_1016_j_bbi_2019_04_037 crossref_primary_10_3389_fpsyt_2023_1123658 crossref_primary_10_1002_jdn_10254 crossref_primary_10_1002_jat_4722 crossref_primary_10_1186_s43045_020_00021_4 crossref_primary_10_1016_j_neubiorev_2013_11_008 crossref_primary_10_1186_s12944_016_0298_0 crossref_primary_10_1093_toxsci_kfu085 crossref_primary_10_3389_fpsyt_2024_1333534 crossref_primary_10_1111_ejn_16204 crossref_primary_10_1016_j_bbadis_2016_07_013 crossref_primary_10_3390_ijms24032703 crossref_primary_10_3390_v12111335 crossref_primary_10_1042_BSR20220713 crossref_primary_10_3389_fpsyt_2019_00152 crossref_primary_10_1016_j_bbr_2014_05_054 crossref_primary_10_1038_npp_2016_158 crossref_primary_10_1038_s41598_020_71171_y crossref_primary_10_3390_brainsci12040460 crossref_primary_10_1016_j_cellimm_2020_104223 crossref_primary_10_1038_s41598_020_62714_4 crossref_primary_10_3389_fpsyt_2022_1006612 crossref_primary_10_1016_j_pnpbp_2024_111135 crossref_primary_10_1111_gbb_12479 crossref_primary_10_1155_2012_959073 crossref_primary_10_3390_ijerph18189784 crossref_primary_10_3390_ijms25052651 crossref_primary_10_1007_s10803_010_1171_z crossref_primary_10_1155_2021_1131280 crossref_primary_10_3389_fphar_2020_00886 crossref_primary_10_1007_s12192_023_01331_2 crossref_primary_10_1007_s10803_016_2960_9 crossref_primary_10_1289_ehp_1104553 crossref_primary_10_1007_s10875_010_9402_9 crossref_primary_10_1016_j_rasd_2011_10_002 crossref_primary_10_1111_imr_13092 crossref_primary_10_1111_j_1601_183X_2011_00723_x crossref_primary_10_1002_brb3_400 crossref_primary_10_1016_j_biopsych_2015_08_036 crossref_primary_10_1111_nmo_14295 crossref_primary_10_1371_journal_pone_0082244 crossref_primary_10_2174_2772432816666210805141257 crossref_primary_10_1016_j_brainres_2023_148443 crossref_primary_10_1016_j_smim_2021_101511 crossref_primary_10_1016_j_bbi_2023_12_003 crossref_primary_10_1186_1742_2094_9_265 crossref_primary_10_1016_j_intimp_2020_106466 crossref_primary_10_1002_aur_1565 crossref_primary_10_1016_j_pbb_2020_172859 crossref_primary_10_1007_s11064_012_0775_4 crossref_primary_10_1016_j_heliyon_2023_e15593 crossref_primary_10_1016_j_bbih_2022_100563 crossref_primary_10_1016_j_reprotox_2022_11_004 crossref_primary_10_1097_WNR_0000000000000905 crossref_primary_10_1016_j_ijdevneu_2012_08_007 crossref_primary_10_1016_j_rasd_2022_102085 crossref_primary_10_5765_jkacap_190039 crossref_primary_10_1016_j_expneurol_2017_04_010 crossref_primary_10_1016_j_neuropharm_2023_109634 crossref_primary_10_1016_j_lfs_2015_07_003 crossref_primary_10_1038_s41598_019_53294_z crossref_primary_10_3390_biom15020207 crossref_primary_10_1016_j_bbadis_2010_12_017 crossref_primary_10_1016_j_bbi_2015_02_001 crossref_primary_10_1159_000323189 crossref_primary_10_1016_j_pnpbp_2018_12_002 crossref_primary_10_1016_j_jpsychires_2019_05_019 crossref_primary_10_1155_2015_972791 crossref_primary_10_1186_2051_5960_1_61 crossref_primary_10_1016_j_ijdevneu_2014_04_004 crossref_primary_10_1016_j_bbi_2016_11_007 crossref_primary_10_2217_fnl_15_11 crossref_primary_10_1016_j_cyto_2019_154740 crossref_primary_10_1002_jmv_25429 crossref_primary_10_1007_s12035_024_04340_z crossref_primary_10_1097_WCO_0b013e3283373514 crossref_primary_10_3390_ijms232415577 crossref_primary_10_1016_j_bbi_2016_05_019 crossref_primary_10_3390_life14091201 crossref_primary_10_1007_s11055_013_9767_3 crossref_primary_10_1016_j_wneu_2016_09_100 crossref_primary_10_3390_ijms24076575 crossref_primary_10_1016_j_jneuroim_2021_577745 crossref_primary_10_1016_j_neulet_2010_01_033 crossref_primary_10_1016_j_neulet_2016_03_043 crossref_primary_10_4137_JCNSD_S6188 crossref_primary_10_1007_s00787_017_1027_6 crossref_primary_10_1007_s11481_013_9462_8 crossref_primary_10_1371_journal_pone_0110356 crossref_primary_10_1016_j_jneuroim_2023_578168 crossref_primary_10_1371_journal_pone_0197060 crossref_primary_10_1159_000319828 crossref_primary_10_1007_s00787_013_0472_0 crossref_primary_10_1016_j_neuro_2019_12_003 crossref_primary_10_3390_ijms24087475 crossref_primary_10_1002_bdr2_1416 crossref_primary_10_1186_s13229_021_00456_4 crossref_primary_10_1016_j_ajpath_2011_03_034 crossref_primary_10_1016_j_biopsych_2017_09_021 crossref_primary_10_1038_tp_2015_142 crossref_primary_10_1016_j_neuro_2016_02_004 crossref_primary_10_1289_ehp_1002835 crossref_primary_10_3389_fimmu_2024_1447385 crossref_primary_10_1007_s12031_018_1192_1 crossref_primary_10_1080_15287394_2010_519317 crossref_primary_10_1371_journal_pone_0075510 crossref_primary_10_1016_j_mcn_2016_09_004 crossref_primary_10_1016_j_eurpsy_2013_02_005 crossref_primary_10_1186_s13229_015_0040_1 crossref_primary_10_1097_EE9_0000000000000028 crossref_primary_10_7453_gahmj_2013_092 crossref_primary_10_46235_1028_7221_13911_LCE crossref_primary_10_1007_s10803_011_1373_z crossref_primary_10_3390_ijms24087443 crossref_primary_10_1016_j_immuni_2021_10_006 crossref_primary_10_1016_j_mehy_2011_08_019 crossref_primary_10_1016_j_rasd_2009_09_011 crossref_primary_10_1016_j_pnpbp_2017_12_015 crossref_primary_10_1007_s10571_020_00882_7 crossref_primary_10_1016_j_bbi_2022_12_001 crossref_primary_10_3928_00485713_20120906_08 crossref_primary_10_21307_ane_2018_008 crossref_primary_10_1038_tp_2011_62 crossref_primary_10_1179_1476830513Y_0000000108 crossref_primary_10_1016_j_bbi_2025_02_030 crossref_primary_10_1155_2015_531518 crossref_primary_10_1007_s12264_023_01055_4 crossref_primary_10_1038_tp_2011_48 crossref_primary_10_1016_j_jneuroim_2020_577430 crossref_primary_10_1371_journal_pone_0134565 crossref_primary_10_1016_j_biopsych_2016_08_024 crossref_primary_10_1016_j_jneuroim_2023_578069 crossref_primary_10_1016_j_jneuroim_2024_578365 crossref_primary_10_1016_j_bbi_2012_07_008 crossref_primary_10_1016_j_bbadis_2012_01_011 crossref_primary_10_1038_tp_2012_19 crossref_primary_10_1080_14728222_2022_2100252 crossref_primary_10_3389_fcimb_2020_00098 crossref_primary_10_3390_ijms23063033 crossref_primary_10_3390_ph10040095 crossref_primary_10_1007_s12035_017_0822_x crossref_primary_10_1016_j_pnpbp_2017_06_034 crossref_primary_10_2217_bmm_12_108 crossref_primary_10_3390_ijms21103576 crossref_primary_10_1016_j_arcmed_2010_10_012 crossref_primary_10_1098_rstb_2016_0160 crossref_primary_10_1002_aur_1530 crossref_primary_10_1016_j_ibneur_2024_10_003 crossref_primary_10_1186_s13059_016_1084_z |
| Cites_doi | 10.1159/000048665 10.1016/j.pediatrneurol.2005.03.014 10.1016/j.jneuroim.2008.04.012 10.1016/j.jri.2005.03.005 10.1016/j.jneuroim.2005.12.007 10.3233/JAD-2006-9105 10.1016/0003-2697(76)90527-3 10.1038/35103559 10.1159/000065416 10.1002/ana.20315 10.1007/s10067-002-0685-y 10.1016/0167-5699(95)80068-9 10.1016/S0165-5728(01)00421-0 10.1038/383787a0 10.1016/j.pediatrneurol.2007.01.012 10.1113/expphysiol.2005.030734 10.1097/01.all.0000162309.97480.45 10.1002/ana.1024 10.1146/annurev.iy.07.040189.003205 10.1002/cyto.b.20021 10.1016/0165-5728(96)00014-8 10.1016/j.jneuroim.2005.11.007 |
| ContentType | Journal Article |
| Copyright | 2008 |
| Copyright_xml | – notice: 2008 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 7TK H94 7X8 5PM |
| DOI | 10.1016/j.jneuroim.2008.12.002 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Neurosciences Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts Neurosciences Abstracts Immunology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1872-8421 |
| EndPage | 116 |
| ExternalDocumentID | PMC2770268 19157572 10_1016_j_jneuroim_2008_12_002 S0165572808004906 1_s2_0_S0165572808004906 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: NCCIH NIH HHS grantid: P01 AT002647 |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29L 4.4 457 4CK 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABFNM ABFRF ABIVO ABJNI ABMAC ABMZM ABTEW ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACIUM ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGEKW AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRLJ AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CJTIS CNWQP CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDW HMG HMK HMO HMQ HVGLF HZ~ IHE J1W KOM L7B LUGTX LX8 M29 M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OP~ OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SIN SNS SPCBC SSH SSI SSN SSZ T5K UNMZH WUQ XJT Z5R ZGI ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG AADPK AAIAV ABLVK ABYKQ AJBFU EFLBG LCYCR ZA5 AAYXX AGRNS CITATION CGR CUY CVF ECM EIF NPM 7T5 7TK H94 7X8 5PM |
| ID | FETCH-LOGICAL-c610t-c35632059df3ec3b52d607d1ed32607e3c79856fa6610b2e97daf52d514f71c03 |
| IEDL.DBID | .~1 |
| ISSN | 0165-5728 |
| IngestDate | Thu Aug 21 17:54:14 EDT 2025 Thu Aug 07 14:54:57 EDT 2025 Thu Jul 10 18:39:02 EDT 2025 Mon Jul 21 06:06:06 EDT 2025 Thu Apr 24 23:11:25 EDT 2025 Tue Jul 01 01:53:17 EDT 2025 Fri Feb 23 02:27:13 EST 2024 Sun Feb 23 10:19:11 EST 2025 Tue Aug 26 17:48:48 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Multiplexed bead analysis Inflammation Immune response Cytokines Flow cytometry method Autistic spectrum disorders (ASD) |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c610t-c35632059df3ec3b52d607d1ed32607e3c79856fa6610b2e97daf52d514f71c03 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://doi.org/10.1016/j.jneuroim.2008.12.002 |
| PMID | 19157572 |
| PQID | 20360901 |
| PQPubID | 23462 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2770268 proquest_miscellaneous_66948986 proquest_miscellaneous_20360901 pubmed_primary_19157572 crossref_citationtrail_10_1016_j_jneuroim_2008_12_002 crossref_primary_10_1016_j_jneuroim_2008_12_002 elsevier_sciencedirect_doi_10_1016_j_jneuroim_2008_12_002 elsevier_clinicalkeyesjournals_1_s2_0_S0165572808004906 elsevier_clinicalkey_doi_10_1016_j_jneuroim_2008_12_002 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-02-15 |
| PublicationDateYYYYMMDD | 2009-02-15 |
| PublicationDate_xml | – month: 02 year: 2009 text: 2009-02-15 day: 15 |
| PublicationDecade | 2000 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Journal of neuroimmunology |
| PublicationTitleAlternate | J Neuroimmunol |
| PublicationYear | 2009 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Abbas, Murphy, Sher (bib1) 1996; 383 Chez, Dowling, Patel, Khanna, Kominsky (bib16) 2007; 36 Simpson (bib21) 2003 Pickering, Cumiskey, O'Connor (bib19) 2005; 90 Grammas, Samany, Thirumangalakudi (bib9) 2006; 9 Ashwood, Wakefield (bib3) 2006; 173 Jyonouchi, Sun, Itokazu (bib11) 2002; 46 Croonenberghs, Bosmans, Deboutte, Kenis, Maes (bib6) 2002; 45 Rice (bib20) 2007; 56 Vargas, Nascimbene, Krishnan, Zimmerman, Pardo (bib25) 2005; 57 Bradford (bib5) 1976; 72 Zimmerman, Jyonouchi, Comi, Connors, Milstien, Varsou, Heyes (bib26) 2005; 35 Biber, Vinet, Boddeke (bib14) 2008; 198 Beutler, Cerami (bib4) 1989; 7 Singh (bib22) 1996; 66 Spadaro, Scrivo, Bombardieri, Riccieri, Rinaldi, Taccari, Valesini (bib23) 2003; 22 Khan, Smith, Reda (bib12) 2004; 61 American Psychiatric Association (bib2) 1994 DuPont, Wang, Wadhwa (bib7) 2005; 66 Liblau, Singer, McDevitt (bib13) 1995; 16 Ngoc, Gold, Tzianabos, Weiss, Celedon (bib18) 2005; 5 Folstein, Rosen-Sheidley (bib8) 2001; 2 Jyonouchi, Sun, Le (bib10) 2001; 120 Molloy, Morrow, Meinzen-Derr, Schleifer, Dienger, Manning-Courtney, Altaye, Wills-Karp (bib15) 2006; 172 Nelson, Grether, Croen (bib17) 2001; 49 Vargas (10.1016/j.jneuroim.2008.12.002_bib25) 2005; 57 Ashwood (10.1016/j.jneuroim.2008.12.002_bib3) 2006; 173 Ngoc (10.1016/j.jneuroim.2008.12.002_bib18) 2005; 5 Biber (10.1016/j.jneuroim.2008.12.002_bib14) 2008; 198 Jyonouchi (10.1016/j.jneuroim.2008.12.002_bib11) 2002; 46 Molloy (10.1016/j.jneuroim.2008.12.002_bib15) 2006; 172 Beutler (10.1016/j.jneuroim.2008.12.002_bib4) 1989; 7 Rice (10.1016/j.jneuroim.2008.12.002_bib20) 2007; 56 Singh (10.1016/j.jneuroim.2008.12.002_bib22) 1996; 66 Nelson (10.1016/j.jneuroim.2008.12.002_bib17) 2001; 49 Folstein (10.1016/j.jneuroim.2008.12.002_bib8) 2001; 2 Jyonouchi (10.1016/j.jneuroim.2008.12.002_bib10) 2001; 120 Chez (10.1016/j.jneuroim.2008.12.002_bib16) 2007; 36 Pickering (10.1016/j.jneuroim.2008.12.002_bib19) 2005; 90 Abbas (10.1016/j.jneuroim.2008.12.002_bib1) 1996; 383 Bradford (10.1016/j.jneuroim.2008.12.002_bib5) 1976; 72 Liblau (10.1016/j.jneuroim.2008.12.002_bib13) 1995; 16 DuPont (10.1016/j.jneuroim.2008.12.002_bib7) 2005; 66 Zimmerman (10.1016/j.jneuroim.2008.12.002_bib26) 2005; 35 Grammas (10.1016/j.jneuroim.2008.12.002_bib9) 2006; 9 Spadaro (10.1016/j.jneuroim.2008.12.002_bib23) 2003; 22 American Psychiatric Association (10.1016/j.jneuroim.2008.12.002_bib2) 1994 Croonenberghs (10.1016/j.jneuroim.2008.12.002_bib6) 2002; 45 Khan (10.1016/j.jneuroim.2008.12.002_bib12) 2004; 61 Simpson (10.1016/j.jneuroim.2008.12.002_bib21) 2003 |
| References_xml | – volume: 5 start-page: 161 year: 2005 end-page: 166 ident: bib18 article-title: Cytokines, allergy, and asthma publication-title: Curr. Opin. Allergy Clin. Immunol. – volume: 2 start-page: 943 year: 2001 end-page: 955 ident: bib8 article-title: Genetics of autism: complex aetiology for a heterogeneous disorder publication-title: Nat. Rev., Genet. – volume: 66 start-page: 143 year: 1996 end-page: 145 ident: bib22 article-title: Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism publication-title: J. Neuroimmunol. – volume: 72 start-page: 248 year: 1976 end-page: 254 ident: bib5 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal. Biochem. – volume: 61 start-page: 35 year: 2004 end-page: 39 ident: bib12 article-title: Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers publication-title: Cytom. B Clin. Cytom. – volume: 22 start-page: 107 year: 2003 end-page: 111 ident: bib23 article-title: Relationship of interleukin-12 and interleukin-13 imbalance with class-specific rheumatoid factors and anticardiolipin antibodies in systemic lupus erythematosus publication-title: Clin. Rheumatol. – volume: 35 start-page: 195 year: 2005 end-page: 201 ident: bib26 article-title: Cerebrospinal fluid and serum markers of inflammation in autism publication-title: Pediatr. Neurol. – volume: 45 start-page: 1 year: 2002 end-page: 6 ident: bib6 article-title: Activation of the inflammatory response system in autism publication-title: Neuropsychobiology – volume: 173 start-page: 126 year: 2006 end-page: 134 ident: bib3 article-title: Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms publication-title: J. Neuroimmunol. – volume: 7 start-page: 625 year: 1989 end-page: 655 ident: bib4 article-title: The biology of cachectin/TNF—a primary mediator of host response publication-title: Annu. Rev. Immunol. – volume: 383 start-page: 787 year: 1996 end-page: 793 ident: bib1 article-title: Functional diversity of helper T lymphocytes publication-title: Nature – year: 1994 ident: bib2 article-title: Diagnostic and Statistical Manual of Mental Disorders – volume: 56 start-page: 12 year: 2007 end-page: 28 ident: bib20 article-title: Prevalence of autism spectrum disorders–Autism and developmental disabilities monitoring network, 14 sites, United state, 2002 publication-title: Morb. Mort. Wkly. Rep. – volume: 198 start-page: 69 year: 2008 end-page: 74 ident: bib14 article-title: Neuron-microglia signaling: chemokines as versatile messengers publication-title: J. Neuroimmunol. – volume: 9 start-page: 51 year: 2006 end-page: 58 ident: bib9 article-title: Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis publication-title: J. Alzheimer's Dis. – volume: 46 start-page: 76 year: 2002 end-page: 84 ident: bib11 article-title: Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder publication-title: Neuropsychobiology – volume: 172 start-page: 198 year: 2006 end-page: 205 ident: bib15 article-title: Elevated cytokine levels in children with autism spectrum disorder publication-title: J. Neuroimmunol. – volume: 57 start-page: 67 year: 2005 end-page: 81 ident: bib25 article-title: Neuroglial activation and neuroinflammation in the brain of patients with autism publication-title: Ann. Neurol. – volume: 66 start-page: 175 year: 2005 end-page: 191 ident: bib7 article-title: Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants publication-title: J. Reprod. Immunol. – volume: 120 start-page: 170 year: 2001 end-page: 179 ident: bib10 article-title: Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression publication-title: J. Neuroimmunol. – volume: 16 start-page: 34 year: 1995 end-page: 38 ident: bib13 article-title: Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases publication-title: Immunol. Today – volume: 90 start-page: 663 year: 2005 end-page: 670 ident: bib19 article-title: Actions of TNF-α on glutaminergic synaptic transmission in the central nervous system publication-title: Exp. Physiol. – year: 2003 ident: bib21 article-title: Characterization of protein complexes, chapter 10 publication-title: Protein and Proteomics – volume: 36 start-page: 361 year: 2007 end-page: 365 ident: bib16 article-title: Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children publication-title: Pediatr. Neurol. – volume: 49 start-page: 597 year: 2001 end-page: 606 ident: bib17 article-title: Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation publication-title: Ann. Neurol. – volume: 45 start-page: 1 year: 2002 ident: 10.1016/j.jneuroim.2008.12.002_bib6 article-title: Activation of the inflammatory response system in autism publication-title: Neuropsychobiology doi: 10.1159/000048665 – volume: 35 start-page: 195 year: 2005 ident: 10.1016/j.jneuroim.2008.12.002_bib26 article-title: Cerebrospinal fluid and serum markers of inflammation in autism publication-title: Pediatr. Neurol. doi: 10.1016/j.pediatrneurol.2005.03.014 – volume: 198 start-page: 69 year: 2008 ident: 10.1016/j.jneuroim.2008.12.002_bib14 article-title: Neuron-microglia signaling: chemokines as versatile messengers publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2008.04.012 – volume: 66 start-page: 175 year: 2005 ident: 10.1016/j.jneuroim.2008.12.002_bib7 article-title: Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants publication-title: J. Reprod. Immunol. doi: 10.1016/j.jri.2005.03.005 – volume: 173 start-page: 126 year: 2006 ident: 10.1016/j.jneuroim.2008.12.002_bib3 article-title: Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2005.12.007 – volume: 9 start-page: 51 year: 2006 ident: 10.1016/j.jneuroim.2008.12.002_bib9 article-title: Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis publication-title: J. Alzheimer's Dis. doi: 10.3233/JAD-2006-9105 – volume: 72 start-page: 248 year: 1976 ident: 10.1016/j.jneuroim.2008.12.002_bib5 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal. Biochem. doi: 10.1016/0003-2697(76)90527-3 – volume: 2 start-page: 943 year: 2001 ident: 10.1016/j.jneuroim.2008.12.002_bib8 article-title: Genetics of autism: complex aetiology for a heterogeneous disorder publication-title: Nat. Rev., Genet. doi: 10.1038/35103559 – volume: 46 start-page: 76 year: 2002 ident: 10.1016/j.jneuroim.2008.12.002_bib11 article-title: Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder publication-title: Neuropsychobiology doi: 10.1159/000065416 – volume: 56 start-page: 12 year: 2007 ident: 10.1016/j.jneuroim.2008.12.002_bib20 article-title: Prevalence of autism spectrum disorders–Autism and developmental disabilities monitoring network, 14 sites, United state, 2002 publication-title: Morb. Mort. Wkly. Rep. – volume: 57 start-page: 67 year: 2005 ident: 10.1016/j.jneuroim.2008.12.002_bib25 article-title: Neuroglial activation and neuroinflammation in the brain of patients with autism publication-title: Ann. Neurol. doi: 10.1002/ana.20315 – volume: 22 start-page: 107 year: 2003 ident: 10.1016/j.jneuroim.2008.12.002_bib23 article-title: Relationship of interleukin-12 and interleukin-13 imbalance with class-specific rheumatoid factors and anticardiolipin antibodies in systemic lupus erythematosus publication-title: Clin. Rheumatol. doi: 10.1007/s10067-002-0685-y – year: 2003 ident: 10.1016/j.jneuroim.2008.12.002_bib21 article-title: Characterization of protein complexes, chapter 10 – volume: 16 start-page: 34 year: 1995 ident: 10.1016/j.jneuroim.2008.12.002_bib13 article-title: Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases publication-title: Immunol. Today doi: 10.1016/0167-5699(95)80068-9 – year: 1994 ident: 10.1016/j.jneuroim.2008.12.002_bib2 – volume: 120 start-page: 170 year: 2001 ident: 10.1016/j.jneuroim.2008.12.002_bib10 article-title: Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression publication-title: J. Neuroimmunol. doi: 10.1016/S0165-5728(01)00421-0 – volume: 383 start-page: 787 year: 1996 ident: 10.1016/j.jneuroim.2008.12.002_bib1 article-title: Functional diversity of helper T lymphocytes publication-title: Nature doi: 10.1038/383787a0 – volume: 36 start-page: 361 year: 2007 ident: 10.1016/j.jneuroim.2008.12.002_bib16 article-title: Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children publication-title: Pediatr. Neurol. doi: 10.1016/j.pediatrneurol.2007.01.012 – volume: 90 start-page: 663 year: 2005 ident: 10.1016/j.jneuroim.2008.12.002_bib19 article-title: Actions of TNF-α on glutaminergic synaptic transmission in the central nervous system publication-title: Exp. Physiol. doi: 10.1113/expphysiol.2005.030734 – volume: 5 start-page: 161 year: 2005 ident: 10.1016/j.jneuroim.2008.12.002_bib18 article-title: Cytokines, allergy, and asthma publication-title: Curr. Opin. Allergy Clin. Immunol. doi: 10.1097/01.all.0000162309.97480.45 – volume: 49 start-page: 597 year: 2001 ident: 10.1016/j.jneuroim.2008.12.002_bib17 article-title: Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation publication-title: Ann. Neurol. doi: 10.1002/ana.1024 – volume: 7 start-page: 625 year: 1989 ident: 10.1016/j.jneuroim.2008.12.002_bib4 article-title: The biology of cachectin/TNF—a primary mediator of host response publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.iy.07.040189.003205 – volume: 61 start-page: 35 year: 2004 ident: 10.1016/j.jneuroim.2008.12.002_bib12 article-title: Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers publication-title: Cytom. B Clin. Cytom. doi: 10.1002/cyto.b.20021 – volume: 66 start-page: 143 year: 1996 ident: 10.1016/j.jneuroim.2008.12.002_bib22 article-title: Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism publication-title: J. Neuroimmunol. doi: 10.1016/0165-5728(96)00014-8 – volume: 172 start-page: 198 year: 2006 ident: 10.1016/j.jneuroim.2008.12.002_bib15 article-title: Elevated cytokine levels in children with autism spectrum disorder publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2005.11.007 |
| SSID | ssj0015349 |
| Score | 2.4903703 |
| Snippet | This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed... Abstract This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 111 |
| SubjectTerms | Adolescent Adult Allergy and Immunology Autistic Disorder - immunology Autistic Disorder - pathology Autistic spectrum disorders (ASD) Brain - immunology Brain - pathology Case-Control Studies Chemokines - metabolism Child Child, Preschool Cytokines Cytokines - metabolism Female Flow cytometry method Humans Immune response Inflammation Male Multiplexed bead analysis Neurology Statistics, Nonparametric Th1 Cells - immunology Th2 Cells - immunology Young Adult |
| Title | Elevated immune response in the brain of autistic patients |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0165572808004906 https://www.clinicalkey.es/playcontent/1-s2.0-S0165572808004906 https://dx.doi.org/10.1016/j.jneuroim.2008.12.002 https://www.ncbi.nlm.nih.gov/pubmed/19157572 https://www.proquest.com/docview/20360901 https://www.proquest.com/docview/66948986 https://pubmed.ncbi.nlm.nih.gov/PMC2770268 |
| Volume | 207 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaqIiEuCFoe20LxAXFLN4ntOOa2qlotrNoDUNGb5cS2yKrNVs0WqRd-OzOxs3QpCASnSMlYiScz9ud5EvLaMc-rsuBJlZk84ZYXiTJ5DepuTZrWmDKDdsjjk2J6yt-fibMNcjDkwmBYZVz7w5rer9bxzjhyc3zZNOOPmIgjsLtS2buvsOw25xKlfP_bKswDFDpAYCBOkPpWlvB8f94XjWwuQkwlmgWjeeUXG9RdAPpzHOWtjenoEXkYESWdhI9-TDZcu0W2Jy2cpi9u6Bvax3j2xvMtcv84utK3ydvDc_cVgKalDaaIOHoVomUdbVoKqJBW2DyCLjw1IJtYzZnGGqzdE3J6dPjpYJrERgpJDehomdRMFCwHIGU9czWrRG6LVNrMWQBvqXSslqoUhTewWadV7pS0xgMRgCkvszplT8lmu2jdc0JZxeGQaASorufM-ArwAk-N8lY46aUaETFwT9exyjg2uzjXQzjZXA9cDy0ws1wD10dkvBp3Geps_HGEHH6OHrJIYd3TsBX820jXRfXtdKY7oNR3RGxE1GrkmpT-1VtfDRKkQYXRL2Nat7juNPqCU8Blv6coCsVLVcL7nwWJ-8EjlQHgljinNVlcEWD58PUnbfOlLyOeSwkH8HLnP-a0Sx4E71qeZOIF2VxeXbuXANKW1V6vhXvk3uTdbHqC19mHz7PvsTw-2g |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VIgEXBC2P5VUfELd08_Aj5lZVrRbo9kIr9WY5sa1m1WarZovUS38749hZuhQEgmsyluPJjP15ngDvbeFoVXKaVJnOE2ooT6TOa1R3o9O09ikz3g45PeSTY_r5hJ2swe6QC-PDKuPeH_b0freOT8aRm-OLphl_9Yk4zHdXKnv3Fb8H9ymqr29jsH2zjPNAjQ4YGKkTT34rTXi2PeurRjbnIajS2wWjfeUXJ9RdBPpzIOWtk2n_CTyOkJLshK9-Cmu23YDNnRav0-fX5APpgzx76_kGPJhGX_omfNw7s98QaRrS-BwRSy5DuKwlTUsQFpLKd48gc0c0Cqcv50xiEdbuGRzv7x3tTpLYSSGpER4tkrpgvMgRSRlX2LqoWG54KkxmDaK3VNiiFrJk3Gk8rdMqt1IY7ZAI0ZQTWZ0Wz2G9nbf2JZCionhL1Ax119FCuwoBA021dIZZ4YQcARu4p-pYZtx3uzhTQzzZTA1cDz0ws1wh10cwXo67CIU2_jhCDD9HDWmkuPEpPAv-baTtov52KlMdUqo7MjYCuRy5IqZ_NevWIEEKddg7ZnRr51ed8s7gFIHZ7yk4l7SUJc7_IkjcDx7JDBG38GtakcUlga8fvvqmbU77OuK5EHgDL1_9x5q24OHkaHqgDj4dfnkNj4KrLU8y9gbWF5dX9i0itkX1rtfI76PFPsU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Elevated+immune+response+in+the+brain+of+autistic+patients&rft.jtitle=Journal+of+neuroimmunology&rft.au=Li%2C+X&rft.au=Chauhan%2C+A&rft.au=Sheikh%2C+A+M&rft.au=Patil%2C+S&rft.date=2009-02-15&rft.issn=0165-5728&rft.volume=207&rft.issue=1-2&rft.spage=111&rft.epage=116&rft_id=info:doi/10.1016%2Fj.jneuroim.2008.12.002&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01655728%2FS0165572809X00020%2Fcov150h.gif |