α1-Acid Glycoprotein Decreases Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice

• Published in: Diabetes (New York, N.Y.) Vol. 61; no. 6; pp. 1584 - 1591
• Main Authors: SPILLER, Fernando, CARLOS, Daniela, SOUTO, Fabricio O, DE FREITAS, Andressa, SOARES, Fernanda S, VIEIRA, Silvio M, PAULA, Francisco J. A, ALVES-FILHO, Jose C, CUNHA, Fernando Q
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2012
• Subjects: Animals; Biological and medical sciences; CD11b Antigen - metabolism; Cell Movement - drug effects; Cell Movement - immunology; Complications; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - immunology; Diabetes Mellitus, Experimental - metabolism; Diabetes. Impaired glucose tolerance; Diabetics; Disease Susceptibility - immunology; Disease Susceptibility - metabolism; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glycoproteins; Health aspects; Insulin - pharmacology; Insulin - therapeutic use; L-Selectin - metabolism; Medical sciences; Mice; Neutrophil Infiltration - drug effects; Neutrophil Infiltration - immunology; Neutrophils; Neutrophils - drug effects; Neutrophils - immunology; Neutrophils - metabolism; Orosomucoid - metabolism; Physiological aspects; Risk factors; Sepsis; Sepsis - immunology; Sepsis - metabolism; Brazil; Endocrinopathy; Infection; Sepsis syndrome; Vertebrata; Sensitivity; Mammalia; Mouse; Animal; Diabetes mellitus; Rodentia; Glycoprotein; Neutrophil

The mechanisms underlying immune deficiency in diabetes are largely unknown. In the present study, we demonstrate that diabetic mice are highly susceptible to polymicrobial sepsis due to reduction in rolling, adhesion, and migration of leukocytes to the focus of infection. In addition, after sepsis...