Virulence of Herpes Simplex Virus 1 Harboring a UAG Stop Codon between the First and Second Initiation Codon in the Thymidine Kinase Gene

• Published in: Japanese Journal of Infectious Diseases Vol. 75; no. 4; pp. 368 - 373
• Main Authors: Nguyen, Phu Hoang Anh, Yamada, Souichi, Harada, Shizuko, Fukushi, Shuetsu, Mizuguchi, Masashi, Saijo, Masayuki
• Format: Journal Article
• Language: English
• Published: Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 31.07.2022; Japan Science and Technology Agency
• Subjects: Acyclovir; acyclovir resistance; amber mutation; Gene expression; Herpes simplex; herpes simplex virus 1; Herpes viruses; Kinases; Lethal dose; Sensitivity; Statistical analysis; Stop codon; Thymidine; Thymidine kinase; viral thymidine kinase; Virulence; Viruses; acyclovir resistance; herpes simplex virus 1; virulence; viral thymidine kinase; amber mutation

Herpes simplex virus 1 (HSV-1)-TK (8UAG) expresses a truncated thymidine kinase (TK) translated from the second initiation codon due to a stop codon (UAG) at the 8th position (counted from the first initiation codon). Here, we showed that the sensitivity of HSV-1-TK (8UAG) to acyclovir (ACV) is simi...