Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 63; no. 2; pp. 728 - 738
• Main Authors: Hoogenboom, Wouter S., Marder, Thomas J., Flores, Veronica L., Huisman, Susanne, Eaton, Hana P., Schneiderman, Jason S., Bolo, Nicolas R., Simonson, Donald C., Jacobson, Alan M., Kubicki, Marek, Shenton, Martha E., Musen, Gail
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.02.2014
• Subjects: Anisotropy; Biological and medical sciences; Brain; Brain mapping; Brain research; Cerebrum - metabolism; Cerebrum - pathology; Cognition disorders; Cognitive disorders; Complications; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetes. Impaired glucose tolerance; Diagnosis; Diffusion Tensor Imaging; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Middle age; Middle Aged; Neural Pathways - anatomy & histology; Neuropathology; Patients; Physiological aspects; Type 2 diabetes; Endocrinopathy; Type 2 diabetes; Human; Central nervous system; Metabolic diseases; White matter; Encephalon

Early detection of brain abnormalities at the preclinical stage can be useful for developing preventive interventions to abate cognitive decline. We examined whether middle-aged type 2 diabetic patients show reduced white matter integrity in fiber tracts important for cognition and whether this abno...