Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement - Tsuji, Kohei; Kobayakawa, Takuya; Ishii, Takahiro; Higashi-Kuwata, Nobuyo; Azuma, Chika; Shinohara, Kouki; Miura, Yutaro; Yamamoto, Kenichi; Nishimura, Soshi; Hattori, Shin-ichiro; Bulut, Haydar; Mitsuya, Hiroaki; et al. (Chemical & pharmaceutical bulletin, 2023)
Keywords: amide bond surrogate; Amides - pharmacology; Animals; Antiviral Agents - chemistry; Benzothiazoles - chemistry; Benzothiazoles - pharmacology; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; coronavirus disease of 2019 (COVID-19); Coronaviruses; COVID-19; Drug development; Drugs; fluorination; Fluorine; Halogens; Inhibitors; Ketones; Life Sciences & Biomedicine; main protease inhibitor; Mice; Pharmacokinetics; Pharmacology & Pharmacy; Physical Sciences; Protease; Protease Inhibitors - chemistry; Pyrrolidines - chemistry; Pyrrolidines - pharmacology; SARS-CoV-2; Science & Technology; Severe acute respiratory syndrome coronavirus 2; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Viral diseases; Viral Nonstructural Proteins; coronavirus disease of 2019 (COVID-19); POTENT; DESIGN; ORALLY BIOAVAILABLE INHIBITOR; COVALENT INHIBITORS; main protease in-hibitor; amide bond surrogate; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); fluorination; HIV-1 PROTEASE; DISCOVERY; 3CL PROTEASE; main protease inhibitor