A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

• Published in: Scientific reports Vol. 8; no. 1; pp. 5198 - 11
• Main Authors: Wong, Tzu-Hsuan, Lee, Chon-Lin, Su, Hsiang-Han, Lee, Chin-Lai, Wu, Chao-Chien, Wang, Chin-Chou, Sheu, Chau-Chyun, Lai, Ruay-Sheng, Leung, Sum-Yee, Lin, Chi-Cheng, Wei, Yu-Feng, Wang, Chien-Jen, Lin, Yu-Chun, Chen, Hua-Ling, Huang, Ming-Shyan, Yen, Jeng-Hsien, Huang, Shau-Ku, Suen, Jau-Ling
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.03.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Hydroxypyrene; 13/31; 631/250/256; 631/250/262; 64/60; 692/699/249/2510/31; 82/58; Adolescent; Adult; Air Pollutants - toxicity; Air pollution; Animals; Antigens; Asthma; Asthma - chemically induced; Asthma - genetics; Asthma - pathology; Asthma - urine; Chronic exposure; Dendritic cells; Dendritic Cells - drug effects; Eosinophilia; Female; Humanities and Social Sciences; Humans; Hypersensitivity; Hypersensitivity - genetics; Hypersensitivity - pathology; Immunoglobulin E; Inflammation; Interleukin 10; Interleukin 4; Interleukin 5; Interleukin 6; Lung - drug effects; Lung - pathology; Lungs; Lymphocytes T; Male; Mice; Middle Aged; multidisciplinary; Particulate Matter; Pneumonia - chemically induced; Pneumonia - genetics; Pneumonia - pathology; Pneumonia - urine; Polycyclic aromatic hydrocarbons; Pyrene; Pyrenes - toxicity; Pyrenes - urine; Receptors, Aryl Hydrocarbon - genetics; Respiratory tract; Science; Science (multidisciplinary); Taiwan - epidemiology; Young Adult; Taiwan

Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma, but its regulatory mechanisms remain incompletely defined. We report herein that elevated levels of urinary 1-hydroxypyrene, a biomarker of PAH exposure, were found in asthmatic subjects ( n  = 39) as comp...