Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 61; no. 11; pp. 2993 - 2997
• Main Authors: Ceriello, Antonio, Novials, Anna, Ortega, Emilio, La Sala, Lucia, Pujadas, Gemma, Testa, Roberto, Bonfigli, Anna Rita, Esposito, Katherine, Giugliano, Dario
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.11.2012
• Subjects: Adult; Antioxidants - administration & dosage; Antioxidants - therapeutic use; Ascorbic Acid - administration & dosage; Ascorbic Acid - therapeutic use; Biological and medical sciences; Breath tests; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - prevention & control; Complications; Complications and side effects; Cross-Over Studies; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endothelium, Vascular - immunology; Endothelium, Vascular - physiopathology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Experiments; Female; Glucose; Glucose - administration & dosage; Glucose - therapeutic use; Humans; Hyperglycemia; Hyperglycemia - etiology; Hyperglycemia - immunology; Hyperglycemia - physiopathology; Hypoglycemia; Hypoglycemia - chemically induced; Hypoglycemia - immunology; Hypoglycemia - physiopathology; Hypoglycemia - therapy; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - adverse effects; Inflammation; Inflammation Mediators - blood; Infusions, Intravenous; Insulin; Insulin - administration & dosage; Insulin - adverse effects; Male; Medical sciences; Oxidative stress; Oxidative Stress - drug effects; Plasma; Risk Factors; Statistical significance; Type 1 diabetes; Vasodilation - drug effects; Vitamin C; Young Adult; Italy; Spain; Endocrinopathy; Human; Immunopathology; Oxidative stress; Autoimmune disease; Metabolic diseases; Inflammation; Hypoglycemia; Endothelium; Hyperglycemia; Type 1 diabetes; Blood vessel; Circulatory system

Currently there is debate on whether hypoglycemia is an independent risk factor for atherosclerosis, but little attention has been paid to the effects of recovery from hypoglycemia. In normal control individuals and in people with type 1 diabetes, recovery from a 2-h induced hypoglycemia was obtaine...