Autocrine Function of Aldehyde Dehydrogenase 1 as a Determinant of Diet- and Sex-Specific Differences in Visceral Adiposity

• Published in: Diabetes (New York, N.Y.) Vol. 62; no. 1; pp. 124 - 136
• Main Authors: Yasmeen, Rumana, Reichert, Barbara, Deiuliis, Jeffrey, Yang, Fangping, Lynch, Alisha, Meyers, Joseph, Sharlach, Molly, Shin, Sangsu, Volz, Katharina S., Green, Kari B., Lee, Kichoon, Alder, Hansjuerg, Duester, Gregg, Zechner, Rudolf, Rajagopalan, Sanjay, Ziouzenkova, Ouliana
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.01.2013
• Subjects: 3T3-L1 Cells; Adipocytes; Adipose tissue; Adipose tissues; Adiposity; Animals; Anti-obesity agents; Biological and medical sciences; Body fat; Dehydrogenases; Development and progression; Diabetes; Diabetes. Impaired glucose tolerance; Diet; Diet, High-Fat; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzymes; Estrogens; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Females; Gastrointestinal surgery; Glucose; Health aspects; Humans; Intra-Abdominal Fat - metabolism; Isoenzymes - physiology; Ligands; Male; Medical sciences; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Obesity; Obesity Studies; Oxidoreductases; Physiological aspects; Proteins; Retinal Dehydrogenase - physiology; Risk factors; Sex Characteristics; Sex differences (Biology); Weight reducing preparations; United States; Endocrinopathy; Adiposity; Diet; Diabetes mellitus; Feeding

Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1−/− mice, but not males, were resistant...