Autocrine Function of Aldehyde Dehydrogenase 1 as a Determinant of Diet- and Sex-Specific Differences in Visceral Adiposity

Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1−/− mice, but not males, were resistant...

Full description

Saved in:
Bibliographic Details
Published inDiabetes (New York, N.Y.) Vol. 62; no. 1; pp. 124 - 136
Main Authors Yasmeen, Rumana, Reichert, Barbara, Deiuliis, Jeffrey, Yang, Fangping, Lynch, Alisha, Meyers, Joseph, Sharlach, Molly, Shin, Sangsu, Volz, Katharina S., Green, Kari B., Lee, Kichoon, Alder, Hansjuerg, Duester, Gregg, Zechner, Rudolf, Rajagopalan, Sanjay, Ziouzenkova, Ouliana
Format Journal Article
LanguageEnglish
Published Alexandria, VA American Diabetes Association 01.01.2013
Subjects
3T3-L1 Cells
Adipocytes
Adipose tissue
Adipose tissues
Adiposity
Animals
Anti-obesity agents
Biological and medical sciences
Body fat
Dehydrogenases
Development and progression
Diabetes
Diabetes. Impaired glucose tolerance
Diet
Diet, High-Fat
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Enzymes
Estrogens
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Females
Gastrointestinal surgery
Glucose
Health aspects
Humans
Intra-Abdominal Fat - metabolism
Isoenzymes - physiology
Ligands
Male
Medical sciences
Metabolism
Metabolites
Mice
Mice, Inbred C57BL
Obesity
Obesity Studies
Oxidoreductases
Physiological aspects
Proteins
Retinal Dehydrogenase - physiology
Risk factors
Sex Characteristics
Sex differences (Biology)
Weight reducing preparations
United States
Endocrinopathy
Adiposity
Diet
Diabetes mellitus
Feeding
Online AccessGet full text

Cover

Abstract Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1−/− mice, but not males, were resistant to high-fat (HF) diet–induced visceral adipose formation, whereas subcutaneous fat was reduced similarly in both groups. Sexual dimorphism in visceral fat (VF) was attributable to elevated adipose triglyceride lipase (Atgl) protein expression localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Aldh1a1−/− mice compared with males. Estrogen decreased Aldh1a3 expression, limiting conversion of retinaldehyde (Rald) to RA. Rald effectively induced Atgl levels via nongenomic mechanisms, demonstrating indirect regulation by estrogen. Experiments in transgenic mice expressing an RA receptor response element (RARE-lacZ) revealed HF diet–induced RARE activation in VF of females but not males. In humans, stromal cells isolated from VF of obese subjects also expressed higher levels of Aldh1 enzymes compared with lean subjects. Our data suggest that an HF diet mediates VF formation through a sex-specific autocrine Aldh1 switch, in which Rald-mediated lipolysis in Ucp1-positive visceral adipocytes is replaced by RA-mediated lipid accumulation. Our data suggest that Aldh1 is a potential target for sex-specific antiobesity therapy.
AbstractList Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1(-/-) mice, but not males, were resistant to high-fat (HF) diet-induced visceral adipose formation, whereas subcutaneous fat was reduced similarly in both groups. Sexual dimorphism in visceral fat (VF) was attributable to elevated adipose triglyceride lipase (Atgl) protein expression localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Aldh1a1(-/-) mice compared with males. Estrogen decreased Aldh1a3 expression, limiting conversion of retinaldehyde (Rald) to RA. Rald effectively induced Atgl levels via nongenomic mechanisms, demonstrating indirect regulation by estrogen. Experiments in transgenic mice expressing an RA receptor response element (RARE-lacZ) revealed HF diet-induced RARE activation in VF of females but not males. In humans, stromal cells isolated from VF of obese subjects also expressed higher levels of Aldh1 enzymes compared with lean subjects. Our data suggest that an HF diet mediates VF formation through a sex-specific autocrine Aldh1 switch, in which Rald-mediated lipolysis in Ucp1-positive visceral adipocytes is replaced by RA-mediated lipid accumulation. Our data suggest that Aldh1 is a potential target for sex-specific antiobesity therapy.
Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing/enzymes, on sex-specific fat depot formation. Female [Aldh1a1.sup.-/-] mice, but not males, were resistant to high-fat (HF) diet--induced visceral adipose formation, whereas subcutaneous fat was reduced similarly in both groups. Sexual dimorphism in visceral fat (VF) was attributable to elevated adipose triglyceride lipase (Atg1) protein expression localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female [Aldh1a1.sup.-/-] mice compared with males. Estrogen decreased Aldh1a3 expression, limiting conversion of retinaldehyde (Rald) to RA. Rald effectively induced Atgl levels via nongenomic mechanisms, demonstrating indirect regulation by estrogen. Experiments in transgenic mice expressing an RA receptor response element (RARE-lacZ) revealed HF diet-induced RARE activation in VF of females but not males. In humans, stromal cells isolated from VF of obese subjects also expressed higher levels of Aldh1 enzymes compared with lean subjects. Our data suggest that an HF diet mediates VF formation through a sex-specific autocrine Aldh1 switch, in which Raid-mediated lipolysis in Ucp1-positive visceral adipocytes is replaced by RA-mediated lipid accumulation. Our data suggest that Aldh1 is a potential target for sex-specific antiobesity therapy. Diabetes 62:124-136, 2013
Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1−/− mice, but not males, were resistant to high-fat (HF) diet–induced visceral adipose formation, whereas subcutaneous fat was reduced similarly in both groups. Sexual dimorphism in visceral fat (VF) was attributable to elevated adipose triglyceride lipase (Atgl) protein expression localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Aldh1a1−/− mice compared with males. Estrogen decreased Aldh1a3 expression, limiting conversion of retinaldehyde (Rald) to RA. Rald effectively induced Atgl levels via nongenomic mechanisms, demonstrating indirect regulation by estrogen. Experiments in transgenic mice expressing an RA receptor response element (RARE-lacZ) revealed HF diet–induced RARE activation in VF of females but not males. In humans, stromal cells isolated from VF of obese subjects also expressed higher levels of Aldh1 enzymes compared with lean subjects. Our data suggest that an HF diet mediates VF formation through a sex-specific autocrine Aldh1 switch, in which Rald-mediated lipolysis in Ucp1-positive visceral adipocytes is replaced by RA-mediated lipid accumulation. Our data suggest that Aldh1 is a potential target for sex-specific antiobesity therapy.
Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1 −/− mice, but not males, were resistant to high-fat (HF) diet–induced visceral adipose formation, whereas subcutaneous fat was reduced similarly in both groups. Sexual dimorphism in visceral fat (VF) was attributable to elevated adipose triglyceride lipase (Atgl) protein expression localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Aldh1a1 −/− mice compared with males. Estrogen decreased Aldh1a3 expression, limiting conversion of retinaldehyde (Rald) to RA. Rald effectively induced Atgl levels via nongenomic mechanisms, demonstrating indirect regulation by estrogen. Experiments in transgenic mice expressing an RA receptor response element (RARE-lacZ) revealed HF diet–induced RARE activation in VF of females but not males. In humans, stromal cells isolated from VF of obese subjects also expressed higher levels of Aldh1 enzymes compared with lean subjects. Our data suggest that an HF diet mediates VF formation through a sex-specific autocrine Aldh1 switch, in which Rald-mediated lipolysis in Ucp1-positive visceral adipocytes is replaced by RA-mediated lipid accumulation. Our data suggest that Aldh1 is a potential target for sex-specific antiobesity therapy.
Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1(-/-) mice, but not males, were resistant to high-fat (HF) diet-induced visceral adipose formation, whereas subcutaneous fat was reduced similarly in both groups. Sexual dimorphism in visceral fat (VF) was attributable to elevated adipose triglyceride lipase (Atgl) protein expression localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Aldh1a1(-/-) mice compared with males. Estrogen decreased Aldh1a3 expression, limiting conversion of retinaldehyde (Rald) to RA. Rald effectively induced Atgl levels via nongenomic mechanisms, demonstrating indirect regulation by estrogen. Experiments in transgenic mice expressing an RA receptor response element (RARE-lacZ) revealed HF diet-induced RARE activation in VF of females but not males. In humans, stromal cells isolated from VF of obese subjects also expressed higher levels of Aldh1 enzymes compared with lean subjects. Our data suggest that an HF diet mediates VF formation through a sex-specific autocrine Aldh1 switch, in which Rald-mediated lipolysis in Ucp1-positive visceral adipocytes is replaced by RA-mediated lipid accumulation. Our data suggest that Aldh1 is a potential target for sex-specific antiobesity therapy.Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1(-/-) mice, but not males, were resistant to high-fat (HF) diet-induced visceral adipose formation, whereas subcutaneous fat was reduced similarly in both groups. Sexual dimorphism in visceral fat (VF) was attributable to elevated adipose triglyceride lipase (Atgl) protein expression localized in clusters of multilocular uncoupling protein 1 (Ucp1)-positive cells in female Aldh1a1(-/-) mice compared with males. Estrogen decreased Aldh1a3 expression, limiting conversion of retinaldehyde (Rald) to RA. Rald effectively induced Atgl levels via nongenomic mechanisms, demonstrating indirect regulation by estrogen. Experiments in transgenic mice expressing an RA receptor response element (RARE-lacZ) revealed HF diet-induced RARE activation in VF of females but not males. In humans, stromal cells isolated from VF of obese subjects also expressed higher levels of Aldh1 enzymes compared with lean subjects. Our data suggest that an HF diet mediates VF formation through a sex-specific autocrine Aldh1 switch, in which Rald-mediated lipolysis in Ucp1-positive visceral adipocytes is replaced by RA-mediated lipid accumulation. Our data suggest that Aldh1 is a potential target for sex-specific antiobesity therapy.
Audience Professional
Author Reichert, Barbara
Shin, Sangsu
Deiuliis, Jeffrey
Yang, Fangping
Yasmeen, Rumana
Duester, Gregg
Ziouzenkova, Ouliana
Lee, Kichoon
Meyers, Joseph
Lynch, Alisha
Alder, Hansjuerg
Rajagopalan, Sanjay
Green, Kari B.
Zechner, Rudolf
Sharlach, Molly
Volz, Katharina S.
Author_xml – sequence: 1
  givenname: Rumana
  surname: Yasmeen
  fullname: Yasmeen, Rumana
  organization: Department of Human Nutrition, The Ohio State University, Columbus, Ohio
– sequence: 2
  givenname: Barbara
  surname: Reichert
  fullname: Reichert, Barbara
  organization: Department of Human Nutrition, The Ohio State University, Columbus, Ohio
– sequence: 3
  givenname: Jeffrey
  surname: Deiuliis
  fullname: Deiuliis, Jeffrey
  organization: Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio
– sequence: 4
  givenname: Fangping
  surname: Yang
  fullname: Yang, Fangping
  organization: Department of Human Nutrition, The Ohio State University, Columbus, Ohio
– sequence: 5
  givenname: Alisha
  surname: Lynch
  fullname: Lynch, Alisha
  organization: Department of Human Nutrition, The Ohio State University, Columbus, Ohio
– sequence: 6
  givenname: Joseph
  surname: Meyers
  fullname: Meyers, Joseph
  organization: Department of Human Nutrition, The Ohio State University, Columbus, Ohio
– sequence: 7
  givenname: Molly
  surname: Sharlach
  fullname: Sharlach, Molly
  organization: Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California
– sequence: 8
  givenname: Sangsu
  surname: Shin
  fullname: Shin, Sangsu
  organization: Department of Animal Sciences, The Ohio State University, Columbus, Ohio
– sequence: 9
  givenname: Katharina S.
  surname: Volz
  fullname: Volz, Katharina S.
  organization: Department of Human Nutrition, The Ohio State University, Columbus, Ohio
– sequence: 10
  givenname: Kari B.
  surname: Green
  fullname: Green, Kari B.
  organization: Mass Spectrometry and Proteomics Facility, The Ohio State University, Columbus, Ohio
– sequence: 11
  givenname: Kichoon
  surname: Lee
  fullname: Lee, Kichoon
  organization: Department of Animal Sciences, The Ohio State University, Columbus, Ohio
– sequence: 12
  givenname: Hansjuerg
  surname: Alder
  fullname: Alder, Hansjuerg
  organization: Nucleic Acid Shared Resource, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio
– sequence: 13
  givenname: Gregg
  surname: Duester
  fullname: Duester, Gregg
  organization: Development and Aging Program, Sanford-Burnham Medical Research Institute, La Jolla, California
– sequence: 14
  givenname: Rudolf
  surname: Zechner
  fullname: Zechner, Rudolf
  organization: Institute of Molecular Biosciences, Karl Franzens University, Graz, Austria
– sequence: 15
  givenname: Sanjay
  surname: Rajagopalan
  fullname: Rajagopalan, Sanjay
  organization: Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio
– sequence: 16
  givenname: Ouliana
  surname: Ziouzenkova
  fullname: Ziouzenkova, Ouliana
  organization: Department of Human Nutrition, The Ohio State University, Columbus, Ohio
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27061659$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22933113$$D View this record in MEDLINE/PubMed
BookMark eNp9k11rFDEUhgep2G31wj8gARH0YtpkMpNMboRla6uw0IuqeBeymZNtymyyJhnp4p83Q7cfq4uci8DJc97kfB0VB847KIrXBJ9UlPLTbkFISTgXz4oJEVSUtOI_DooJxqTKfsEPi6MYbzDGLNuL4rCqBKWE0Enxezokr4N1gM4Hp5P1DnmDpn0H15sO0Nl4BL8EpyIgglREKjsThJV1yqURPrOQSqRch67gtrxag7bG6uw2BgI4DRFZh77bqCGoHk07u_bRps3L4rlRfYRX2_O4-Hb-6evsczm_vPgym85LzQhOZW2AYSwYbyi02nBe16IGshDtoq24EjVvWNdi1VbAas1q3BJTCywI60C1BOhx8fFOdz0sVtBpcCn_Q66DXamwkV5ZuXvj7LVc-l-SNhXDDc4C77cCwf8cICa5GpPpe-XAD1GSitMaU8JpRt_-hd74IbicXqaYIES07Am1VD1I64zP7-pRVE4poVw0oiKZKvdQuRVjGfMEGJvdO_zJHj5bByur9wZ82AnITILbtFRDjLK9mP_vM1tW-76HJcjcsNnlLv_madEfqn0_ehl4twVU1Ko3QTlt4yPHMSOsEZk7veN08DEGMFLbpMZBzdnZXhIsxyWQ4xLIcQke03qIuBf9l_0DEksBUQ
CODEN DIAEAZ
CitedBy_id crossref_primary_10_1016_j_abb_2015_01_002
crossref_primary_10_1016_j_nutres_2021_08_002
crossref_primary_10_1016_j_abb_2013_06_020
crossref_primary_10_3390_cells11030425
crossref_primary_10_3390_nu6030950
crossref_primary_10_1016_j_trsl_2017_10_005
crossref_primary_10_1002_mnfr_201600685
crossref_primary_10_1016_j_bbamcr_2013_09_012
crossref_primary_10_4103_1673_5374_244777
crossref_primary_10_1172_JCI141799
crossref_primary_10_3389_fphys_2021_681562
crossref_primary_10_1016_j_bbrep_2020_100831
crossref_primary_10_1186_s13293_017_0131_0
crossref_primary_10_1038_s41598_019_50628_9
crossref_primary_10_1038_s41586_020_2856_x
crossref_primary_10_4161_adip_24075
crossref_primary_10_1016_j_biomaterials_2020_119839
crossref_primary_10_1016_j_bbadis_2016_05_025
crossref_primary_10_3390_nu14061312
crossref_primary_10_2147_IJN_S467909
crossref_primary_10_1097_IN9_0000000000000051
crossref_primary_10_3390_ijms21093150
crossref_primary_10_1007_s10522_013_9450_7
crossref_primary_10_1038_srep22862
crossref_primary_10_1016_j_ygeno_2023_110773
crossref_primary_10_1093_gerona_glt069
crossref_primary_10_1002_stem_2599
crossref_primary_10_1038_s43018_023_00622_y
crossref_primary_10_1128_MCB_01106_13
crossref_primary_10_1111_acel_12064
crossref_primary_10_1186_s12885_018_4572_6
crossref_primary_10_1016_j_bbi_2021_11_018
crossref_primary_10_1017_S0007114513001396
crossref_primary_10_1021_jf5056584
crossref_primary_10_1111_cts_13259
crossref_primary_10_1152_physiolgenomics_00148_2012
crossref_primary_10_3390_ijms25137155
crossref_primary_10_1080_10408398_2023_2227258
crossref_primary_10_1016_j_physbeh_2016_02_007
crossref_primary_10_1002_wdev_264
crossref_primary_10_1146_annurev_nutr_071816_064827
crossref_primary_10_3390_ani9090655
crossref_primary_10_3389_fnut_2024_1418159
crossref_primary_10_1002_mnfr_201300181
crossref_primary_10_1016_j_pharmthera_2019_01_006
crossref_primary_10_1096_fj_201600263rr
crossref_primary_10_1111_xen_12318
Cites_doi 10.1006/geno.2001.6546
10.1128/MCB.23.13.4637-4648.2003
10.1096/fj.08-120923
10.1038/nm1587
10.1017/S1368980009991261
10.1210/en.2004-0514
10.1182/blood.V92.8.2712
10.1080/13813450802334752
10.1007/s11745-007-3146-1
10.1161/CIRCULATIONAHA.106.673756
10.2337/db11-1620
10.1073/pnas.0807740105
10.1038/oby.2007.505
10.2337/db11-0154
10.1016/j.devcel.2009.12.019
10.1124/pr.58.4.7
10.1152/physiolgenomics.00182.2010
10.1101/gad.5.8.1333
10.1111/j.1365-2826.2011.02135.x
10.1172/JCI40253
10.1074/jbc.M706763200
10.1016/j.cell.2008.09.002
10.1074/jbc.M004987200
10.1096/fj.09-147207
10.1371/journal.pone.0016376
10.1038/oby.2010.56
10.1096/fj.07-8739com
10.1161/01.CIR.0000146395.64065.BA
10.1124/pr.58.4.4
10.1016/j.biomaterials.2012.04.035
10.1161/CIRCULATIONAHA.107.739714
10.1016/j.cmet.2011.05.002
10.2527/jas.2010-3339
10.1016/j.fertnstert.2005.10.054
10.1152/ajpendo.00317.2005
10.1152/ajpcell.00547.2009
10.1128/MCB.01742-08
10.1016/j.jnutbio.2010.12.014
10.1126/science.1123965
10.1096/fj.06-7964com
10.1038/ijo.2010.12
10.1210/me.2010-0465
10.1073/pnas.90.15.7293
10.1007/s11745-010-3422-3
ContentType Journal Article
Copyright 2014 INIST-CNRS
COPYRIGHT 2013 American Diabetes Association
COPYRIGHT 2013 American Diabetes Association
Copyright American Diabetes Association Jan 2013
2013 by the American Diabetes Association. 2013
Copyright_xml – notice: 2014 INIST-CNRS
– notice: COPYRIGHT 2013 American Diabetes Association
– notice: COPYRIGHT 2013 American Diabetes Association
– notice: Copyright American Diabetes Association Jan 2013
– notice: 2013 by the American Diabetes Association. 2013
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
8GL
3V.
7RV
7X7
7XB
88E
88I
8AF
8AO
8C1
8FE
8FH
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BBNVY
BEC
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
HCIFZ
K9-
K9.
KB0
LK8
M0R
M0S
M1P
M2O
M2P
M7P
MBDVC
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
S0X
7X8
5PM
DOI 10.2337/db11-1779
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: High School
ProQuest Central (Corporate)
Nursing & Allied Health Database
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
STEM Database
ProQuest Pharma Collection
Public Health Database
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
eLibrary
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
SciTech Premium Collection
Consumer Health Database (Alumni)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Biological Sciences
Consumer Health Database
ProQuest Health & Medical Collection
Medical Database
Research Library
Science Database
Biological Science Database
Research Library (Corporate)
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
SIRS Editorial
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
elibrary
ProQuest AP Science
SciTech Premium Collection
ProQuest Central China
ProQuest One Applied & Life Sciences
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Family Health
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest One Academic Middle East (New)
SIRS Editorial
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Family Health (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Research Library
ProQuest Public Health
ProQuest Central Basic
ProQuest Science Journals
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Research Library Prep

CrossRef

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1939-327X
EndPage 136
ExternalDocumentID PMC3526050
2864616701
A313795921
22933113
27061659
10_2337_db11_1779
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GeographicLocations United States
GeographicLocations_xml – name: United States
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: P30 CA016058
– fundername: NCI NIH HHS
  grantid: P30-CA-16058-30
– fundername: NEI NIH HHS
  grantid: R01 EY013969
– fundername: NCRR NIH HHS
  grantid: UL1RR025755
– fundername: NIEHS NIH HHS
  grantid: R01 ES017290
– fundername: NIDDK NIH HHS
  grantid: R21-DK-088522
– fundername: NIDDK NIH HHS
  grantid: R21 DK088522
– fundername: NIDDK NIH HHS
  grantid: F32-DK-083903
– fundername: NCRR NIH HHS
  grantid: S10 RR023647
– fundername: NCRR NIH HHS
  grantid: UL1 RR025755
GroupedDBID ---
.55
.XZ
08P
0R~
18M
29F
2WC
354
4.4
53G
5GY
5RE
5RS
5VS
6PF
7RV
7X7
88E
88I
8AF
8AO
8C1
8FE
8FH
8FI
8FJ
8G5
8GL
8R4
8R5
AAFWJ
AAKAS
AAQQT
AAWTL
AAYEP
AAYOK
AAYXX
ABOCM
ABUWG
ACGFO
ACGOD
ACPRK
ADBBV
ADGHP
ADZCM
AEGXH
AENEX
AERZD
AFKRA
AHMBA
AIAGR
AIZAD
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AZQEC
BAWUL
BBNVY
BCR
BCU
BEC
BENPR
BES
BHPHI
BKEYQ
BKNYI
BLC
BPHCQ
BTFSW
BVXVI
CCPQU
CITATION
CS3
DIK
DU5
DWQXO
E3Z
EBS
EDB
EJD
EMOBN
EX3
F5P
FRP
FYUFA
GICCO
GNUQQ
GUQSH
GX1
H13
HCIFZ
HMCUK
HZ~
IAG
IAO
IEA
IHR
INH
INR
IOF
IPO
ITC
K-O
K2M
K9-
KQ8
L7B
LK8
M0R
M1P
M2O
M2P
M2Q
M5~
M7P
NAPCQ
O5R
O5S
O9-
OB3
OHH
OK1
OVD
P2P
PCD
PEA
PHGZM
PHGZT
PQQKQ
PROAC
PSQYO
Q2X
RHI
RPM
S0X
SJFOW
SJN
SV3
TDI
TEORI
TR2
UKHRP
VVN
W8F
WH7
WOQ
WOW
X7M
YFH
YHG
YOC
ZY1
~KM
.GJ
1CY
8F7
AAYJJ
AFFNX
AI.
C1A
H~9
IQODW
J5H
MVM
N4W
PJZUB
PPXIY
PQGLB
VH1
XOL
YQJ
ZGI
ZXP
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
3V.
7XB
8FK
K9.
MBDVC
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c610t-4fe60096753e8cf774494e1b98b827a94756d80a82e64c64081f490916dea81e3
IEDL.DBID 7X7
ISSN 0012-1797
1939-327X
IngestDate Thu Aug 21 14:04:21 EDT 2025
Fri Jul 11 04:58:14 EDT 2025
Fri Jul 25 19:34:29 EDT 2025
Tue Jun 17 21:08:24 EDT 2025
Thu Jun 12 23:32:17 EDT 2025
Tue Jun 10 20:28:04 EDT 2025
Fri Jun 27 04:36:21 EDT 2025
Tue Jun 10 19:52:06 EDT 2025
Mon Jul 21 06:05:24 EDT 2025
Mon Jul 21 09:13:28 EDT 2025
Thu Apr 24 23:10:20 EDT 2025
Tue Jul 01 03:04:09 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Endocrinopathy
Adiposity
Diet
Diabetes mellitus
Feeding
Language English
License CC BY 4.0
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c610t-4fe60096753e8cf774494e1b98b827a94756d80a82e64c64081f490916dea81e3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-General Information-1
content type line 14
ObjectType-Feature-3
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
R.Y. and B.R. contributed equally to this work.
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC3526050
PMID 22933113
PQID 1269119863
PQPubID 34443
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3526050
proquest_miscellaneous_1273403173
proquest_journals_1269119863
gale_infotracmisc_A313795921
gale_infotracgeneralonefile_A313795921
gale_infotracacademiconefile_A313795921
gale_incontextgauss_8GL_A313795921
gale_incontextcollege_GICCO_A313795921
pubmed_primary_22933113
pascalfrancis_primary_27061659
crossref_citationtrail_10_2337_db11_1779
crossref_primary_10_2337_db11_1779
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2013-01-01
PublicationDateYYYYMMDD 2013-01-01
PublicationDate_xml – month: 01
  year: 2013
  text: 2013-01-01
  day: 01
PublicationDecade 2010
PublicationPlace Alexandria, VA
PublicationPlace_xml – name: Alexandria, VA
– name: United States
– name: New York
PublicationTitle Diabetes (New York, N.Y.)
PublicationTitleAlternate Diabetes
PublicationYear 2013
Publisher American Diabetes Association
Publisher_xml – name: American Diabetes Association
References Ziouzenkova (2022031210542356200_B20) 2007; 13
Gaidhu (2022031210542356200_B33) 2010; 298
Weir (2022031210542356200_B50) 1990; 6
Li (2022031210542356200_B23) 2004; 145
Pasquali (2022031210542356200_B10) 2006; 85
Lasa (2022031210542356200_B29) 2012; 23
Berry (2022031210542356200_B18) 2009; 29
Zhang (2022031210542356200_B4) 2008; 117
Tchoukalova (2022031210542356200_B8) 2010; 18
Ahmadian (2022031210542356200_B36) 2011; 13
Yasmeen (2022031210542356200_B11) 2012
Chen (2022031210542356200_B43) 2008; 22
Empana (2022031210542356200_B2) 2004; 110
Deiuliis (2022031210542356200_B26) 2011; 6
Li (2022031210542356200_B41) 2010; 18
De Botton (2022031210542356200_B16) 1998; 92
Chen (2022031210542356200_B40) 2010; 120
Deshmukh-Taskar (2022031210542356200_B5) 2009; 12
Kim (2022031210542356200_B31) 2006; 291
Hessel (2022031210542356200_B47) 2007; 282
Koutsari (2022031210542356200_B6) 2011; 60
Fan (2022031210542356200_B27) 2003; 23
Ström (2022031210542356200_B49) 2009; 23
Rossant (2022031210542356200_B28) 1991; 5
Berry (2022031210542356200_B17) 2012; 61
Oh (2022031210542356200_B30) 2011; 89
Li (2022031210542356200_B1) 2007; 15
Repa (2022031210542356200_B22) 1993; 90
Moenter (2022031210542356200_B45) 2012; 24
Elizondo (2022031210542356200_B19) 2000; 275
Deiuliis (2022031210542356200_B34) 2008; 43
Deiuliis (2022031210542356200_B35) 2010; 45
Trasino (2022031210542356200_B25) 2007; 232
Caimari (2022031210542356200_B37)
Zamboni (2022031210542356200_B7) 1992; 16
Wang (2022031210542356200_B24) 2001; 74
Haemmerle (2022031210542356200_B32) 2006; 312
Reichert (2022031210542356200_B15) 2011; 25
Zhang (2022031210542356200_B48) 2007; 21
Canoy (2022031210542356200_B3) 2007; 116
Germain (2022031210542356200_B12) 2006; 58
Perrini (2022031210542356200_B9) 2008; 114
Yang (2022031210542356200_B38) 2012; 33
Grove (2022031210542356200_B42) 2010; 34
Poon (2022031210542356200_B44) 2008; 105
Ross (2022031210542356200_B39) 2011; 43
Kiefer (2022031210542356200_B21)
Duester (2022031210542356200_B14) 2008; 134
Germain (2022031210542356200_B13) 2006; 58
Moise (2022031210542356200_B46) 2010; 24
16647374 - Fertil Steril. 2006 May;85(5):1319-40
20484817 - J Clin Invest. 2010 Jun;120(6):2040-8
20509000 - Lipids. 2010 Jun;45(6):479-89
20157318 - Int J Obes (Lond). 2010 Jun;34(6):989-1000
21436255 - Mol Endocrinol. 2011 May;25(5):799-809
21298111 - PLoS One. 2011;6(1):e16376
22561685 - Nat Med. 2012 Jun;18(6):918-25
17712061 - FASEB J. 2008 Jan;22(1):236-45
16675698 - Science. 2006 May 5;312(5774):734-7
8394016 - Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7293-7
18946788 - Arch Physiol Biochem. 2008 Oct;114(4):277-86
21704731 - Biochim Biophys Acta. 2012 Jan;1821(1):190-7
2136000 - Nutrition. 1990 May-Jun;6(3):213-21
18189154 - Lipids. 2008 Mar;43(3):215-25
19940255 - FASEB J. 2010 Apr;24(4):1261-70
11386761 - Genomics. 2001 Jun 1;74(2):245-50
9763554 - Blood. 1998 Oct 15;92(8):2712-8
17132853 - Pharmacol Rev. 2006 Dec;58(4):760-72
16705060 - Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E115-27
19073915 - Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20303-8
22575837 - Biomaterials. 2012 Aug;33(22):5638-49
19364826 - Mol Cell Biol. 2009 Jun;29(12):3286-96
1907940 - Genes Dev. 1991 Aug;5(8):1333-44
17529981 - Nat Med. 2007 Jun;13(6):695-702
20107043 - Am J Physiol Cell Physiol. 2010 Apr;298(4):C961-71
18805086 - Cell. 2008 Sep 19;134(6):921-31
19246492 - FASEB J. 2009 Jul;23(7):2307-16
21641555 - Cell Metab. 2011 Jun 8;13(6):739-48
20230754 - Dev Cell. 2010 Mar 16;18(3):480-5
21659500 - Diabetes. 2011 Aug;60(8):2032-40
17435174 - FASEB J. 2007 Sep;21(11):2886-96
17526768 - Exp Biol Med (Maywood). 2007 Jun;232(6):762-71
15492315 - Circulation. 2004 Nov 2;110(18):2781-5
17132850 - Pharmacol Rev. 2006 Dec;58(4):712-25
1323546 - Int J Obes Relat Metab Disord. 1992 Jul;16(7):495-504
12808103 - Mol Cell Biol. 2003 Jul;23(13):4637-48
21944063 - J Nutr Biochem. 2012 Sep;23(9):1041-50
20300084 - Obesity (Silver Spring). 2010 Oct;18(10):1875-80
21543206 - J Nutr Biochem. 2012 Apr;23(4):379-84
15205379 - Endocrinology. 2004 Oct;145(10):4756-62
21496126 - J Neuroendocrinol. 2012 Jan;24(1):117-21
19744354 - Public Health Nutr. 2009 Dec;12(12):2493-503
21045116 - Physiol Genomics. 2011 Jan 7;43(1):57-67
10995752 - J Biol Chem. 2000 Dec 15;275(50):39747-53
22396202 - Diabetes. 2012 May;61(5):1112-21
17855355 - J Biol Chem. 2007 Nov 16;282(46):33553-61
20952523 - J Anim Sci. 2011 Feb;89(2):367-75
18362231 - Circulation. 2008 Apr 1;117(13):1658-67
18071080 - Circulation. 2007 Dec 18;116(25):2933-43
17228050 - Obesity (Silver Spring). 2007 Jan;15(1):216-24
References_xml – volume: 74
  start-page: 245
  year: 2001
  ident: 2022031210542356200_B24
  article-title: Analysis of mouse retinal dehydrogenase type 2 promoter and expression
  publication-title: Genomics
  doi: 10.1006/geno.2001.6546
– volume: 23
  start-page: 4637
  year: 2003
  ident: 2022031210542356200_B27
  article-title: Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.23.13.4637-4648.2003
– volume: 23
  start-page: 2307
  year: 2009
  ident: 2022031210542356200_B49
  article-title: Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL
  publication-title: FASEB J
  doi: 10.1096/fj.08-120923
– volume: 13
  start-page: 695
  year: 2007
  ident: 2022031210542356200_B20
  article-title: Retinaldehyde represses adipogenesis and diet-induced obesity
  publication-title: Nat Med
  doi: 10.1038/nm1587
– ident: 2022031210542356200_B37
  article-title: Adipose triglyceride lipase expression and fasting regulation are differently affected by cold exposure in adipose tissues of lean and obese Zucker rats
  publication-title: J Nutr Biochem
– volume: 12
  start-page: 2493
  year: 2009
  ident: 2022031210542356200_B5
  article-title: Dietary patterns associated with metabolic syndrome, sociodemographic and lifestyle factors in young adults: the Bogalusa Heart Study
  publication-title: Public Health Nutr
  doi: 10.1017/S1368980009991261
– volume: 145
  start-page: 4756
  year: 2004
  ident: 2022031210542356200_B23
  article-title: Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus
  publication-title: Endocrinology
  doi: 10.1210/en.2004-0514
– volume: 92
  start-page: 2712
  year: 1998
  ident: 2022031210542356200_B16
  article-title: Incidence, clinical features, and outcome of all trans-retinoic acid syndrome in 413 cases of newly diagnosed acute promyelocytic leukemia
  publication-title: Blood
  doi: 10.1182/blood.V92.8.2712
– volume: 114
  start-page: 277
  year: 2008
  ident: 2022031210542356200_B9
  article-title: Biological specificity of visceral adipose tissue and therapeutic intervention
  publication-title: Arch Physiol Biochem
  doi: 10.1080/13813450802334752
– volume: 43
  start-page: 215
  year: 2008
  ident: 2022031210542356200_B34
  article-title: Developmental, hormonal, and nutritional regulation of porcine adipose triglyceride lipase (ATGL)
  publication-title: Lipids
  doi: 10.1007/s11745-007-3146-1
– volume: 116
  start-page: 2933
  year: 2007
  ident: 2022031210542356200_B3
  article-title: Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.673756
– volume: 61
  start-page: 1112
  year: 2012
  ident: 2022031210542356200_B17
  article-title: Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesity
  publication-title: Diabetes
  doi: 10.2337/db11-1620
– volume: 105
  start-page: 20303
  year: 2008
  ident: 2022031210542356200_B44
  article-title: Retinoic acid-gated sequence-specific translational control by RARalpha
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0807740105
– volume: 15
  start-page: 216
  year: 2007
  ident: 2022031210542356200_B1
  article-title: Increasing trends in waist circumference and abdominal obesity among US adults
  publication-title: Obesity (Silver Spring)
  doi: 10.1038/oby.2007.505
– volume: 60
  start-page: 2032
  year: 2011
  ident: 2022031210542356200_B6
  article-title: Storage of circulating free fatty acid in adipose tissue of postabsorptive humans: quantitative measures and implications for body fat distribution
  publication-title: Diabetes
  doi: 10.2337/db11-0154
– volume: 18
  start-page: 480
  year: 2010
  ident: 2022031210542356200_B41
  article-title: Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2009.12.019
– volume: 58
  start-page: 760
  year: 2006
  ident: 2022031210542356200_B13
  article-title: International Union of Pharmacology. LXIII. Retinoid X receptors
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.58.4.7
– volume: 43
  start-page: 57
  year: 2011
  ident: 2022031210542356200_B39
  article-title: Multiple cytochrome P-450 genes are concomitantly regulated by vitamin A under steady-state conditions and by retinoic acid during hepatic first-pass metabolism
  publication-title: Physiol Genomics
  doi: 10.1152/physiolgenomics.00182.2010
– volume: 5
  start-page: 1333
  year: 1991
  ident: 2022031210542356200_B28
  article-title: Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis
  publication-title: Genes Dev
  doi: 10.1101/gad.5.8.1333
– volume: 24
  start-page: 117
  year: 2012
  ident: 2022031210542356200_B45
  article-title: Rapid nongenomic effects of oestradiol on GnRH neurons
  publication-title: J Neuroendocrinol
  doi: 10.1111/j.1365-2826.2011.02135.x
– volume: 120
  start-page: 2040
  year: 2010
  ident: 2022031210542356200_B40
  article-title: A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium
  publication-title: J Clin Invest
  doi: 10.1172/JCI40253
– start-page: 190
  volume-title: Biochim Biophys Acta
  year: 2012
  ident: 2022031210542356200_B11
  article-title: The contribution of vitamin A to autocrine regulation of fat depots
– volume: 282
  start-page: 33553
  year: 2007
  ident: 2022031210542356200_B47
  article-title: CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M706763200
– volume: 134
  start-page: 921
  year: 2008
  ident: 2022031210542356200_B14
  article-title: Retinoic acid synthesis and signaling during early organogenesis
  publication-title: Cell
  doi: 10.1016/j.cell.2008.09.002
– volume: 275
  start-page: 39747
  year: 2000
  ident: 2022031210542356200_B19
  article-title: Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor alpha and CCAAT/enhancer-binding protein beta
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M004987200
– volume: 24
  start-page: 1261
  year: 2010
  ident: 2022031210542356200_B46
  article-title: Increased adiposity in the retinol saturase-knockout mouse
  publication-title: FASEB J
  doi: 10.1096/fj.09-147207
– volume: 6
  start-page: e16376
  year: 2011
  ident: 2022031210542356200_B26
  article-title: Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0016376
– volume: 18
  start-page: 1875
  year: 2010
  ident: 2022031210542356200_B8
  article-title: Sex- and depot-dependent differences in adipogenesis in normal-weight humans
  publication-title: Obesity (Silver Spring)
  doi: 10.1038/oby.2010.56
– volume: 16
  start-page: 495
  year: 1992
  ident: 2022031210542356200_B7
  article-title: Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships
  publication-title: Int J Obes Relat Metab Disord
– volume: 22
  start-page: 236
  year: 2008
  ident: 2022031210542356200_B43
  article-title: All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane-associated RARalpha
  publication-title: FASEB J
  doi: 10.1096/fj.07-8739com
– volume: 110
  start-page: 2781
  year: 2004
  ident: 2022031210542356200_B2
  article-title: Sagittal abdominal diameter and risk of sudden death in asymptomatic middle-aged men: the Paris Prospective Study I
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000146395.64065.BA
– volume: 58
  start-page: 712
  year: 2006
  ident: 2022031210542356200_B12
  article-title: International Union of Pharmacology. LX. Retinoic acid receptors
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.58.4.4
– volume: 33
  start-page: 5638
  year: 2012
  ident: 2022031210542356200_B38
  article-title: The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-l-lysine
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.04.035
– volume: 117
  start-page: 1658
  year: 2008
  ident: 2022031210542356200_B4
  article-title: Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.107.739714
– volume: 13
  start-page: 739
  year: 2011
  ident: 2022031210542356200_B36
  article-title: Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2011.05.002
– volume: 89
  start-page: 367
  year: 2011
  ident: 2022031210542356200_B30
  article-title: Cloning of avian G(0)/G(1) switch gene 2 genes and developmental and nutritional regulation of G(0)/G(1) switch gene 2 in chicken adipose tissue
  publication-title: J Anim Sci
  doi: 10.2527/jas.2010-3339
– volume: 6
  start-page: 213
  year: 1990
  ident: 2022031210542356200_B50
  article-title: New methods for calculating metabolic rate with special reference to protein metabolism. 1949
  publication-title: Nutrition
– volume: 85
  start-page: 1319
  year: 2006
  ident: 2022031210542356200_B10
  article-title: Obesity and androgens: facts and perspectives
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2005.10.054
– volume: 291
  start-page: E115
  year: 2006
  ident: 2022031210542356200_B31
  article-title: The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00317.2005
– volume: 298
  start-page: C961
  year: 2010
  ident: 2022031210542356200_B33
  article-title: Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00547.2009
– ident: 2022031210542356200_B21
  article-title: Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
  publication-title: Nat Med
– volume: 29
  start-page: 3286
  year: 2009
  ident: 2022031210542356200_B18
  article-title: All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.01742-08
– volume: 23
  start-page: 379
  year: 2012
  ident: 2022031210542356200_B29
  article-title: Resveratrol regulates lipolysis via adipose triglyceride lipase
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2010.12.014
– volume: 312
  start-page: 734
  year: 2006
  ident: 2022031210542356200_B32
  article-title: Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
  publication-title: Science
  doi: 10.1126/science.1123965
– volume: 21
  start-page: 2886
  year: 2007
  ident: 2022031210542356200_B48
  article-title: Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse
  publication-title: FASEB J
  doi: 10.1096/fj.06-7964com
– volume: 34
  start-page: 989
  year: 2010
  ident: 2022031210542356200_B42
  article-title: A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice
  publication-title: Int J Obes (Lond)
  doi: 10.1038/ijo.2010.12
– volume: 232
  start-page: 762
  year: 2007
  ident: 2022031210542356200_B25
  article-title: Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP
  publication-title: Exp Biol Med (Maywood)
– volume: 25
  start-page: 799
  year: 2011
  ident: 2022031210542356200_B15
  article-title: Concerted action of aldehyde dehydrogenases influences depot-specific fat formation
  publication-title: Mol Endocrinol
  doi: 10.1210/me.2010-0465
– volume: 90
  start-page: 7293
  year: 1993
  ident: 2022031210542356200_B22
  article-title: All-trans-retinol is a ligand for the retinoic acid receptors
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.90.15.7293
– volume: 45
  start-page: 479
  year: 2010
  ident: 2022031210542356200_B35
  article-title: Beta(3)-adrenergic signaling acutely down regulates adipose triglyceride lipase in brown adipocytes
  publication-title: Lipids
  doi: 10.1007/s11745-010-3422-3
– reference: 21704731 - Biochim Biophys Acta. 2012 Jan;1821(1):190-7
– reference: 1907940 - Genes Dev. 1991 Aug;5(8):1333-44
– reference: 9763554 - Blood. 1998 Oct 15;92(8):2712-8
– reference: 11386761 - Genomics. 2001 Jun 1;74(2):245-50
– reference: 16647374 - Fertil Steril. 2006 May;85(5):1319-40
– reference: 20300084 - Obesity (Silver Spring). 2010 Oct;18(10):1875-80
– reference: 19073915 - Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20303-8
– reference: 19246492 - FASEB J. 2009 Jul;23(7):2307-16
– reference: 17132853 - Pharmacol Rev. 2006 Dec;58(4):760-72
– reference: 20484817 - J Clin Invest. 2010 Jun;120(6):2040-8
– reference: 17228050 - Obesity (Silver Spring). 2007 Jan;15(1):216-24
– reference: 18071080 - Circulation. 2007 Dec 18;116(25):2933-43
– reference: 21298111 - PLoS One. 2011;6(1):e16376
– reference: 1323546 - Int J Obes Relat Metab Disord. 1992 Jul;16(7):495-504
– reference: 18805086 - Cell. 2008 Sep 19;134(6):921-31
– reference: 19940255 - FASEB J. 2010 Apr;24(4):1261-70
– reference: 20509000 - Lipids. 2010 Jun;45(6):479-89
– reference: 22575837 - Biomaterials. 2012 Aug;33(22):5638-49
– reference: 17526768 - Exp Biol Med (Maywood). 2007 Jun;232(6):762-71
– reference: 21641555 - Cell Metab. 2011 Jun 8;13(6):739-48
– reference: 22561685 - Nat Med. 2012 Jun;18(6):918-25
– reference: 21045116 - Physiol Genomics. 2011 Jan 7;43(1):57-67
– reference: 22396202 - Diabetes. 2012 May;61(5):1112-21
– reference: 10995752 - J Biol Chem. 2000 Dec 15;275(50):39747-53
– reference: 8394016 - Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7293-7
– reference: 21659500 - Diabetes. 2011 Aug;60(8):2032-40
– reference: 16675698 - Science. 2006 May 5;312(5774):734-7
– reference: 17132850 - Pharmacol Rev. 2006 Dec;58(4):712-25
– reference: 18189154 - Lipids. 2008 Mar;43(3):215-25
– reference: 15492315 - Circulation. 2004 Nov 2;110(18):2781-5
– reference: 20952523 - J Anim Sci. 2011 Feb;89(2):367-75
– reference: 2136000 - Nutrition. 1990 May-Jun;6(3):213-21
– reference: 21944063 - J Nutr Biochem. 2012 Sep;23(9):1041-50
– reference: 17435174 - FASEB J. 2007 Sep;21(11):2886-96
– reference: 15205379 - Endocrinology. 2004 Oct;145(10):4756-62
– reference: 17855355 - J Biol Chem. 2007 Nov 16;282(46):33553-61
– reference: 16705060 - Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E115-27
– reference: 19364826 - Mol Cell Biol. 2009 Jun;29(12):3286-96
– reference: 18946788 - Arch Physiol Biochem. 2008 Oct;114(4):277-86
– reference: 20157318 - Int J Obes (Lond). 2010 Jun;34(6):989-1000
– reference: 20230754 - Dev Cell. 2010 Mar 16;18(3):480-5
– reference: 17712061 - FASEB J. 2008 Jan;22(1):236-45
– reference: 21543206 - J Nutr Biochem. 2012 Apr;23(4):379-84
– reference: 20107043 - Am J Physiol Cell Physiol. 2010 Apr;298(4):C961-71
– reference: 21496126 - J Neuroendocrinol. 2012 Jan;24(1):117-21
– reference: 17529981 - Nat Med. 2007 Jun;13(6):695-702
– reference: 18362231 - Circulation. 2008 Apr 1;117(13):1658-67
– reference: 12808103 - Mol Cell Biol. 2003 Jul;23(13):4637-48
– reference: 21436255 - Mol Endocrinol. 2011 May;25(5):799-809
– reference: 19744354 - Public Health Nutr. 2009 Dec;12(12):2493-503
SSID ssj0006060
Score 2.3206003
Snippet Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1...
SourceID pubmedcentral
proquest
gale
pubmed
pascalfrancis
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 124
SubjectTerms 3T3-L1 Cells
Adipocytes
Adipose tissue
Adipose tissues
Adiposity
Animals
Anti-obesity agents
Biological and medical sciences
Body fat
Dehydrogenases
Development and progression
Diabetes
Diabetes. Impaired glucose tolerance
Diet
Diet, High-Fat
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Enzymes
Estrogens
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Females
Gastrointestinal surgery
Glucose
Health aspects
Humans
Intra-Abdominal Fat - metabolism
Isoenzymes - physiology
Ligands
Male
Medical sciences
Metabolism
Metabolites
Mice
Mice, Inbred C57BL
Obesity
Obesity Studies
Oxidoreductases
Physiological aspects
Proteins
Retinal Dehydrogenase - physiology
Risk factors
Sex Characteristics
Sex differences (Biology)
Weight reducing preparations
Title Autocrine Function of Aldehyde Dehydrogenase 1 as a Determinant of Diet- and Sex-Specific Differences in Visceral Adiposity
URI https://www.ncbi.nlm.nih.gov/pubmed/22933113
https://www.proquest.com/docview/1269119863
https://www.proquest.com/docview/1273403173
https://pubmed.ncbi.nlm.nih.gov/PMC3526050
Volume 62
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9RAEF-0BRGk-FlPz2MVqb6EZpO9bPIk8dqziK2iVu4tbPajDZTkbHLQ4j_vTLKXNnL4kkD2x5LN7M7-ZjI7Q8hbzW0iYWv34lwEHle58KSwiZf7Uwnr3NrE4Hnn45Po6JR_XkwXzuFWu7DKtU5sFbWuFPrI91kQwbpM4ij8sPztYdUo_LvqSmjcJduYugxDusSiN7h8IOfdERQWYBpO0WUWCsJQ7OscQ7kERnDd2o-cVn6wlDV8IduVttjEPf8Noby1J80fkh1HJmnaSf8RuWPKx-Tesftd_oT8SVdNpfB8H53D_oUyoJWl6YU259fa0AO8XVYwh2Avo4zKmkp42AfIIPigMI1HZanpD3PlteXqbaHgsXUnBWtalPRXUSv0btFUF20c2PVTcjo__Dk78ly1BU8BhWo8bk2EBg3YLyZWFmghT7hheRLncSBkwsU00rEv48BEXEUcuITlCdCNSBsZMxM-I1tlVZrnhGoOWhPsbp1YyQ2IntlQGiAqzIL1mIcj8n79zTPlUpFjRYyLDEwSFE-G4slQPCPypocuu_wbm0B7KLgM81mUGDCjOqdLBuObfc3SkIVYUj1g0NsQeCZXdZ3Fn74MQO8cyFbwVkq6gwowNsyVNUDuDZBnXabwTcDxAAhLWA2aJ4MZ1480EEC3oikMcLyegpnTMXV2syJG5HXfjF1j3FxpqhViRMhBbwvA7HYz9qZzYHohY9AiBnO5B2Dm8WFLWZy3GcixqII_9V_8_7VekvtBWzwEHVZjstVcrswroHBNPmnXKVzjGZuQ7Y-HJ9--_wWD7kc8
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZGJwESQtwplGEQDF6i1YkbJw8IlXWlY-1AbEN7M44vW6UpKUsrqPhP_EbOadJsQRVve4oUf7LinONzsc-FkFeGu1iBaveiRPge14nwlHCxl7Q7Cva5c7HFfOfRfjg44p-OO8dr5M8yFwbDKpcycSGoTabxjHyL-SHsyzgKg_eTHx52jcLb1WULjYIt9uz8J7hs-bvdHtD3te_3dw63B17ZVcDTYCpMPe5siIY72Ok20g7MHx5zy5I4SiJfqJiLTmiitop8G3IdctCZjsegVkNjVcRsAPNeI-s8AFemQdY_7Ox_-VrJfnAHiqQX5mPhT1HUMvKDQGyZBIPHBMaMXdKApR64NVE50MQVzTRWWbv_Bm1e0oL9O-R2ab7SbsFvd8maTe-R66Pygv4--d2dTTONGYW0DxoTqU4zR7tnxp7OjaU9fJxnwLWgPSmjKqcKXlYhOQjuje3Uoyo19MD-8g4mdhE2CK9dmZuY03FKv41zjedptGvGi8iz-QNydCWUeEgaaZbax4QaDnIaPH0TO8UtMBtzgbJgGjEH_moSNMnb5T-Xuix-jj04ziQ4QUgeieSRSJ4meVlBJ0XFj1WgTSScxAoaKYbo6OKYR8L6tj_LbsACbOLuM5itDjxRszyX0cdhDfSmBLkMvkqrMjUC1obVuWrIzRrypKhNvgrYqgFBaOja8EaN46qV-gIMvLADC2wtWVCWUi2XF3uwSV5Uwzg1RuqlNpshRgQcNIUAzKOCYy8mB9syYAxGRI2XKwDWOq-PpOPTRc1zbOPQ7rSf_P-znpMbg8PRUA539_eekpv-onUJHpe1SGN6PrPPwICcJhvlrqXk-1ULir9pnYDk
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbGkCYkhLhTKMMgGLxErR0nTh4QqlbKxi4gjU19M45jb5WmpCytoOKf8es4J0mzBVW87alS_MmKe-7OuRDyOhUu1mDavSiR3BMmkZ6WLvaSfqBBzp2LLdY7HxyGO8fi8zgYr5E_y1oYTKtc6sRSUae5wTvyHuMhyGUchX7P1WkRX4ejD9MfHk6Qwi-ty3EaFYvs2cVPCN-K97tDoPUbzkcfv23vePWEAc-A2zDzhLMhOvHgs9vIOHCFRCwsS-IoibjUsZBBmEZ9HXEbChMKsJ9OxGBiw9TqiFkf9r1Bbko_YChjctwEe30IDKryF8axBaisuhpx35e9NME0MonZY1dsYW0Rbk91AdRx1ViNVX7vv-mbV-zh6C65UzuydFBx3j2yZrP7ZOOg_lT_gPwezGe5wdpCOgLbifSnuaOD89SeLVJLh_hzkQP_gh2ljOqCanjYJOcgeDixM4_qLKVH9pd3NLVlAiE8dnWVYkEnGT2ZFAZv1uggnZQ5aIuH5Pha6PCIrGd5Zp8QmgrQ2BDzp7HTwgLbMedrC04ScxC5Jn6HvFv-58rUbdBxGse5gnAIyaOQPArJ0yGvGui06v2xCrSFhFPYSyNDrjTVhY-C821_UQOf-TjOnTPYrQ081fOiUNGn_RbobQ1yObyV0XWRBJwN-3S1kFst5GnVpXwVsNsCgvowreXNFsc1J-USXL0wgAN2lyyoav1WqEtp7JCXzTJujTl7mc3niJG-AJshAfO44tjLzcHL9BmDFdni5QaAXc_bK9nkrOx-jgMd-kH_6f9f6wXZAPWg9ncP956RW7ycYYL3Zl2yPruY2-fgSc6SzVJkKfl-3TriLxmVg7Q
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Autocrine+function+of+aldehyde+dehydrogenase+1+as+a+determinant+of+diet-+and+sex-specific+differences+in+visceral+adiposity&rft.jtitle=Diabetes+%28New+York%2C+N.Y.%29&rft.au=Yasmeen%2C+Rumana&rft.au=Reichert%2C+Barbara&rft.au=Deiuliis%2C+Jeffrey&rft.au=Yang%2C+Fangping&rft.date=2013-01-01&rft.pub=American+Diabetes+Association&rft.issn=0012-1797&rft.volume=62&rft.issue=1&rft.spage=124&rft_id=info:doi/10.2337%2Fdb11-1779&rft.externalDBID=8GL&rft.externalDocID=A313795921
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0012-1797&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0012-1797&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0012-1797&client=summon