Effect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 62; no. 9; pp. 3224 - 3231
• Main Authors: Weil, E. Jennifer, Fufaa, Gudeta, Jones, Lois I., Lovato, Tracy, Lemley, Kevin V., Hanson, Robert L., Knowler, William C., Bennett, Peter H., Yee, Berne, Myers, Bryan D., Nelson, Robert G.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.09.2013
• Subjects: Adult; Aged; Associated diseases and complications; Biological and medical sciences; Clinical trials; Complications and side effects; Development and progression; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes. Impaired glucose tolerance; Diabetic nephropathies; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - prevention & control; Dosage and administration; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; Indians, North American; Kidney diseases; Kidneys; Losartan; Losartan - therapeutic use; Male; Medical sciences; Middle Aged; Native North Americans; Nephrology. Urinary tract diseases; Original Research; Prevention; Risk factors; Side effects; Type 2 diabetes; Urinary system involvement in other diseases. Miscellaneous; Young Adult; United States; Endocrinopathy; Kidney disease; Type 2 diabetes; Imidazole derivatives; Tetrazole derivatives; Urinary system disease; Peptide hormone; Non peptide compound; Metabolic diseases; Prevention; Concomitant disease; Octapeptide; Renin angiotensin system; Biphenyl derivatives; Losartan; Indian; Diabetic nephropathy; Sartan derivatives; Angiotensin antagonist; Angiotensin II

Angiotensin receptor blockers are renoprotective in hypertensive azotemic patients with type 2 diabetes, but their efficacy in early diabetic kidney disease is uncertain. We performed a 6-year randomized clinical trial in 169 American Indians with type 2 diabetes and normoalbuminuria (albumin/creati...