Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy

• Published in: Diabetes (New York, N.Y.) Vol. 60; no. 11; pp. 2954 - 2962
• Main Authors: Eller, Kathrin, Kirsch, Alexander, Wolf, Anna M., Sopper, Sieghart, Tagwerker, Andrea, Stanzl, Ursula, Wolf, Dominik, Patsch, Wolfgang, Rosenkranz, Alexander R., Eller, Philipp
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.11.2011
• Subjects: Analysis; Animals; Body fat; Cytokines - genetics; Cytokines - metabolism; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - immunology; Diabetes Mellitus, Type 2 - metabolism; Diabetic nephropathies; Diabetic Nephropathies - immunology; Diabetic Nephropathies - physiopathology; Diabetic Nephropathies - prevention & control; Diabetic Nephropathies - therapy; Diabetic nephropathy; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene expression; Gene Expression Regulation; Genetic aspects; Glucose; Humans; Ikaros Transcription Factor - genetics; Ikaros Transcription Factor - metabolism; Inflammation; Insulin Resistance; Intra-Abdominal Fat - metabolism; Intra-Abdominal Fat - pathology; Kidney - metabolism; Kidney - pathology; Kidney - surgery; Lymphocyte Depletion - adverse effects; Lymphocyte Transfusion; Lymphocytes; Male; Messenger RNA; Metabolism; Mice; Mice, Obese; Monoclonal antibodies; Obesity; Obesity - immunology; Obesity - metabolism; Obesity - pathology; Pathogenesis; Pathophysiology; Physiological aspects; Receptors, Leptin - genetics; Research design; RNA, Messenger - metabolism; Specific Pathogen-Free Organisms; T cells; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; T-Lymphocytes, Regulatory - pathology; Tumor necrosis factor-TNF; Austria

To assess the potential role of FoxP3-expressing regulatory T cells (Tregs) in reversing obesity-linked insulin resistance and diabetic nephropathy in rodent models and humans. To characterize the role of Tregs in insulin resistance, human visceral adipose tissue was first evaluated for Treg infiltr...