Two Cases of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome with High Serum Procalcitonin Levels, Including the First Case Complicated with Adrenal Hemorrhaging

• Published in: Internal Medicine Vol. 56; no. 10; pp. 1247 - 1252
• Main Authors: Nara, Mizuho, Komatsuda, Atsushi, Itoh, Fumiko, Kaga, Hajime, Saitoh, Masaya, Togashi, Masaru, Kameoka, Yoshihiro, Wakui, Hideki, Takahashi, Naoto
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2017; Japan Science and Technology Agency
• Subjects: Adrenal Gland Diseases - complications; adrenal hemorrhage; Adult; Antibodies, Monoclonal, Humanized - therapeutic use; Asian Continental Ancestry Group; Calcitonin - blood; Case Report; Castleman disease; Castleman's disease; Edema - diagnosis; Edema - drug therapy; Etiology; Female; Fever; Fever - diagnosis; Fever - drug therapy; Fibrosis; Fibrosis - diagnosis; Fibrosis - drug therapy; Hemorrhage - drug therapy; Hemorrhage - etiology; Humans; Inflammatory diseases; Internal medicine; Kidneys; Male; Middle Aged; Monoclonal antibodies; POEMS Syndrome - diagnosis; POEMS Syndrome - drug therapy; Procalcitonin; Renal failure; Renal Insufficiency - diagnosis; Renal Insufficiency - drug therapy; Reticulin; Rituximab; TAFRO syndrome; Thrombocytopenia; Thrombocytopenia - diagnosis; Thrombocytopenia - drug therapy; Thrombocytopenia - therapy; Treatment Outcome; TAFRO syndrome; adrenal hemorrhage; procalcitonin; Castleman disease; rituximab

Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis/Renal failure, and Organomegaly (TAFRO) syndrome is a recently described systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly. It has an acute or subacute onset of u...