Phenotypic and functional analysis of bovine peripheral blood dendritic cells before parturition by a novel purification method

• Published in: Animal science journal Vol. 89; no. 7; pp. 1011 - 1019
• Main Authors: Zhuang, Tao, Urakawa, Megumi, Sato, Hidetoshi, Sato, Yuko, Taguchi, Teruaki, Umino, Tsuyoshi, Katto, Shiro, Tanaka, Koutaro, Yoshimura, Kozue, Takada, Naokazu, Kobayashi, Hiroko, Ito, Megumi, Rose, Michael T., Kiku, Yoshio, Nagasawa, Yuya, Kitazawa, Haruki, Watanabe, Kouichi, Nochi, Tomonori, Hayashi, Tomohito, Aso, Hisashi
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.07.2018; John Wiley and Sons Inc
• Subjects: Adaptive immunity; Adaptive Immunity - immunology; Animals; Antigen Presentation - immunology; Antigen-presenting cells; Antigens; Blood; cattle; Cattle - blood; CD11c antigen; CD40 antigen; CD80 antigen; CD86 antigen; Cell Separation - methods; cytokine; Cytokines; Cytokines - metabolism; dendritic cell; Dendritic cells; Dendritic Cells - immunology; Female; Functional analysis; Humans; Immune response; Immune system; Immune Tolerance - immunology; Immunity, Innate - immunology; Immunological tolerance; immunosuppression; Inducible T-Cell Co-Stimulator Protein; Leukocytes, Mononuclear; Lymphocytes T; Major histocompatibility complex; Molecular chains; Original; ORIGINAL ARTICLES; Parturition; Parturition - immunology; Peripheral blood mononuclear cells; Phenotype; Phenotypes; positive‐selection; Pregnancy; Purification; purification methods; T cell receptors; T-lymphocytes; cytokine; phenotype; positive-selection; cattle; dendritic cell

Dendritic cells (DCs) are specialized antigen presenting cells specializing in antigen uptake and processing, and play an important role in the innate and adaptive immune response. A subset of bovine peripheral blood DCs was identified as CD172a+/CD11c+/MHC (major histocompatibility complex) class I...