胰腺癌的疼痛及其治疗的研究进展
胰腺癌是一种恶性程度较高的消化系统肿瘤,发病率持续上升,预后极差,5年生存率低于5%,死亡率极高,几乎达100%。胰腺癌主要症状之一是疼痛,大部分属于神经源性起源,显著降低患者的生活质量并影响功能活动。胰腺癌最常见的疼痛治疗是药物镇痛治疗,这是基于WHO镇痛阶梯规则。但是它并不总奏效,且许多不良反应降低了患者生活质量。胰腺疼痛的侵入性治疗主要包括腹腔神经丛阻滞和内脏神经切断术,可显著降低疼痛水平,有助于提高生活质量。微创手术不应在最后阶段使用,应考虑在疾病早期阶段（如WHO镇痛阶梯治疗的第一或第二步）。本文综合分析了目前临床上胰腺癌疼痛治疗方法,评估其有效性,希望获取更多对治疗胰腺癌疼痛有帮助...
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| Published in | 复旦学报（医学版） Vol. 45; no. 1; pp. 126 - 133 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
复旦大学附属中山医院介入治疗科 上海200032
2018
上海市影像医学研究所 上海200032 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-8467 |
| DOI | 10.3969/j.issn.1672-8467.2018.01.020 |
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| Abstract | 胰腺癌是一种恶性程度较高的消化系统肿瘤,发病率持续上升,预后极差,5年生存率低于5%,死亡率极高,几乎达100%。胰腺癌主要症状之一是疼痛,大部分属于神经源性起源,显著降低患者的生活质量并影响功能活动。胰腺癌最常见的疼痛治疗是药物镇痛治疗,这是基于WHO镇痛阶梯规则。但是它并不总奏效,且许多不良反应降低了患者生活质量。胰腺疼痛的侵入性治疗主要包括腹腔神经丛阻滞和内脏神经切断术,可显著降低疼痛水平,有助于提高生活质量。微创手术不应在最后阶段使用,应考虑在疾病早期阶段（如WHO镇痛阶梯治疗的第一或第二步）。本文综合分析了目前临床上胰腺癌疼痛治疗方法,评估其有效性,希望获取更多对治疗胰腺癌疼痛有帮助的信息。 |
|---|---|
| AbstractList | 胰腺癌是一种恶性程度较高的消化系统肿瘤,发病率持续上升,预后极差,5年生存率低于5%,死亡率极高,几乎达100%。胰腺癌主要症状之一是疼痛,大部分属于神经源性起源,显著降低患者的生活质量并影响功能活动。胰腺癌最常见的疼痛治疗是药物镇痛治疗,这是基于WHO镇痛阶梯规则。但是它并不总奏效,且许多不良反应降低了患者生活质量。胰腺疼痛的侵入性治疗主要包括腹腔神经丛阻滞和内脏神经切断术,可显著降低疼痛水平,有助于提高生活质量。微创手术不应在最后阶段使用,应考虑在疾病早期阶段（如WHO镇痛阶梯治疗的第一或第二步）。本文综合分析了目前临床上胰腺癌疼痛治疗方法,评估其有效性,希望获取更多对治疗胰腺癌疼痛有帮助的信息。 R735.9; 胰腺癌是一种恶性程度较高的消化系统肿瘤,发病率持续上升,预后极差,5年生存率低于5％,死亡率极高,几乎达100％.胰腺癌主要症状之一是疼痛,大部分属于神经源性起源,显著降低患者的生活质量并影响功能活动.胰腺癌最常见的疼痛治疗是药物镇痛治疗,这是基于WHO镇痛阶梯规则.但是它并不总奏效,且许多不良反应降低了患者生活质量.胰腺疼痛的侵入性治疗主要包括腹腔神经丛阻滞和内脏神经切断术,可显著降低疼痛水平,有助于提高生活质量.微创手术不应在最后阶段使用,应考虑在疾病早期阶段(如WHO镇痛阶梯治疗的第一或第二步).本文综合分析了目前临床上胰腺癌疼痛治疗方法,评估其有效性,希望获取更多对治疗胰腺癌疼痛有帮助的信息. |
| Abstract_FL | Pancreatic cancer is a malignant digestive system tumor.The incidence of pancreatic cancer is rising,the prognosis is very poor,the mortality rate is extremely high (almost 100％),and the 5-year survival rate is less than 5％.One of the main symptoms of this tumor is pain and mostly neuropathic origin,which significantly decreases the quality of life and the impacts on patient's functional activity.The most common pain treatment for pancreatic cancer is drug analgesia therapy,which is based on the WHO analgesic ladder rule.However,it is not always effective,and many side effects reduce the quality of life of patients.Invasive treatment of pain in pancreatic cancer mainly includes neurolytic celiac plexus block and splanchnicectomy,which can significantly reduce the level of pain and help to improve the quality of life.Invasive remedies should not be applied at the final stage and should be considered in the early stages of the disease (such as the first or second step of the WHO analgesic ladder).This paper comprehensively analyzes the current clinical treatment of pancreatic cancer pain and evaluates its effectiveness,and hopes to provide more information on the treatment of pain in patients with pancreatic cancer. |
| Author | 王成刚;王小林 |
| AuthorAffiliation | 复旦大学附属中山医院介入治疗科,上海200032;上海市影像医学研究所,上海200032 |
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| Author_FL | WANG Cheng-gang |
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| Author_xml | – sequence: 1 fullname: 王成刚;王小林 |
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| Keywords | 腹腔神经丛阻滞 胸腔镜内脏神经切断术 pancreatic cancer invasive remedies thoracoscopic splanchnicectomy 胰腺癌 疼痛管理 pain management neurolytic coeliac plexus block 侵入性治疗 |
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| Notes | WANG Cheng-gang1,2, WANG Xiao-lin1,2（1. Department of I nterventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ;2.Shanghai Institute of Medical Imaging, Shanghai 200032 ,China） Pancreatic cancer is a malignant digestive system tumor.The incidence of pancreatic cancer is rising,the prognosis is very poor,the mortality rate is extremely high（almost 100%）,and the 5-year survival rate is less than 5%.One of the main symptoms of this tumor is pain and mostly neuropathic origin,which significantly decreases the quality of life and the impacts on patient＇s functional activity.The most common pain treatment for pancreatic cancer is drug analgesia therapy,which is based on the WHO analgesic ladder rule.However,it is not always effective,and many side effects reduce the quality of life of patients.Invasive treatment of pain in pancreatic cancer mainly includes neurolytic celiac plexus block and splanchnicectomy,which can significantly reduce the level of pain and help to improve the qualit |
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| Publisher | 复旦大学附属中山医院介入治疗科 上海200032 上海市影像医学研究所 上海200032 |
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| SubjectTerms | 侵入性治疗 疼痛管理 胰腺癌 胸腔镜内脏神经切断术 腹腔神经丛阻滞 |
| Title | 胰腺癌的疼痛及其治疗的研究进展 |
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