Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

• Published in: Lancet neurology Vol. 11; no. 12; pp. 1057 - 1065
• Main Authors: Fleisher, Adam S, Chen, Kewei, Quiroz, Yakeel T, Jakimovich, Laura J, Gomez, Madelyn Gutierrez, Langois, Carolyn M, Langbaum, Jessica BS, Ayutyanont, Napatkamon, Roontiva, Auttawut, Thiyyagura, Pradeep, Lee, Wendy, Mo, Hua, Lopez, Liliana, Moreno, Sonia, Acosta-Baena, Natalia, Giraldo, Margarita, Garcia, Gloria, Reiman, Rebecca A, Huentelman, Matthew J, Kosik, Kenneth S, Tariot, Pierre N, Lopera, Francisco, Reiman, Eric M
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2012
• Subjects: Adult; Alzheimer Disease - diagnosis; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - genetics; Amyloid beta-Peptides - metabolism; Aniline Compounds - metabolism; Cohort Studies; Cross-Sectional Studies; Ethylene Glycols - metabolism; Female; Fluorine Radioisotopes - metabolism; Humans; Male; Middle Aged; Neurology; Positron-Emission Tomography - methods; Presenilin-1 - genetics; Registries; Young Adult

Fibrillar amyloid-β (Aβ) is thought to begin accumulating in the brain many years before the onset of clinical impairment in patients with Alzheimer's disease. By assessing the accumulation of Aβ in people at risk of genetic forms of Alzheimer's disease, we can identify how early preclinic...