RBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

• Published in: Genome Biology Vol. 25; no. 1; p. 102
• Main Authors: Du, Xian, Qin, Wenying, Yang, Chunyu, Dai, Lin, San, Mingkui, Xia, Yingdan, Zhou, Siyu, Wang, Mengyang, Wu, Shuang, Zhang, Shaorui, Zhou, Huiting, Li, Fangshu, He, Fang, Tang, Jingfeng, Chen, Jia-Yu, Zhou, Yu, Xiao, Rui
• Format: Journal Article
• Language: English
• Published: England BioMed Central 19.04.2024; BMC
• Subjects: 5′ pausing; Chromatin; DNA-directed RNA polymerase; Elongation; Gene expression; genes; Genomes; Homeostasis; Humans; loci; Molecular modelling; Positive Transcriptional Elongation Factor B - genetics; Positive Transcriptional Elongation Factor B - metabolism; Proteins; RBM22; RNA; RNA polymerase; RNA polymerase II; RNA Polymerase II - metabolism; RNA Splicing; RNA Splicing Factors - genetics; Splicing factors; transcription (genetics); Transcription elongation; Transcription termination; Transcription, Genetic; Transcriptional Elongation Factors - genetics; Transcriptional Elongation Factors - metabolism; Transcription termination; Transcription elongation; 5′ pausing; RNA polymerase II; RBM22

Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms of their involvement in transcriptional processes remain poorly understood. Here, we describe a direct role of splicing factor RBM22 in c...