IgG subclasses determine pathways of anaphylaxis in mice

• Published in: Journal of allergy and clinical immunology Vol. 139; no. 1; pp. 269 - 280.e7
• Main Authors: Beutier, Héloïse, PharmD, Gillis, Caitlin M., BSci, Iannascoli, Bruno, BTS, Godon, Ophélie, MSc, England, Patrick, PhD, Sibilano, Riccardo, PhD, Reber, Laurent L., PhD, Galli, Stephen J., MD, Cragg, Mark S., PhD, Van Rooijen, Nico, PhD, Mancardi, David A., PhD, Bruhns, Pierre, PhD, Jönsson, Friederike, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2017; Elsevier Limited; Elsevier
• Subjects: Allergies; Allergy and Immunology; Anaphylaxis; Anaphylaxis - immunology; Animals; Antibodies, Monoclonal - immunology; basophil; Colleges & universities; Female; Haptens - immunology; histamine; Histamine - immunology; Human subjects; IgG; IgG Fc receptor; Immunoglobulin E - immunology; Immunoglobulin G - immunology; Immunoglobulins; Immunology; Life Sciences; macrophage; Mice, Inbred C57BL; Mice, Transgenic; monocyte; mouse model; Myeloid Cells - immunology; neutrophil; Neutrophils; platelet-activating factor; Protein Subunits - immunology; Receptors, IgG - genetics; Receptors, IgG - immunology; Rodents; Serum Albumin, Bovine - immunology; California; Fluorescein isothiocyanate; Mast cell protease 1; Association rate; histamine; RU; Gfi1; IgG; Neonatal IgG receptor; platelet-activating factor; basophil; neutrophil; mMCP-1; Growth factor independence 1; FITC; Anaphylaxis; TNP; FcRn; C57Bl/6 wild-type; Dissociation equilibrium constant; Trinitrophenyl; TRIM21; WT; PSA; Tripartite motif-containing protein 21; mouse model; Affinity constant; macrophage; Resonance units; K off; IgG Fc receptor; K A; K D; PAF; K on; Passive systemic anaphylaxis; monocyte; Dissociation rate; FcγR; KA; KD; Koff; Kon

Background Animal models have demonstrated that allergen-specific IgG confers sensitivity to systemic anaphylaxis that relies on IgG Fc receptors (FcγRs). Mouse IgG2a and IgG2b bind activating FcγRI, FcγRIII, and FcγRIV and inhibitory FcγRIIB; mouse IgG1 binds only FcγRIII and FcγRIIB. Although thes...