Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions

• Published in: Cytokine & growth factor reviews Vol. 24; no. 5; pp. 433 - 442
• Main Authors: Sun, Zhongjie, Lei, Han, Zhang, Zhonge
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2013
• Subjects: Advanced Basic Science; Animals; Apoptosis; B lymphocyte; B-Lymphocytes - enzymology; B-Lymphocytes - pathology; Chemokine; Cytokines - genetics; Cytokines - metabolism; Endothelial Cells; Humans; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Macrophages - enzymology; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Monocyte; Nicotinamide Phosphoribosyltransferase - genetics; Nicotinamide Phosphoribosyltransferase - metabolism; Pre-B cell enhancing factor; Receptors, Vascular Endothelial Growth Factor - genetics; Receptors, Vascular Endothelial Growth Factor - metabolism; T lymphocyte; T-Lymphocytes - enzymology; T-Lymphocytes - pathology; Chemokine; B lymphocyte; T lymphocyte; Monocyte; Pre-B cell enhancing factor

Pre-B cell colony enhancing factor (PBEF) is regarded as a proinflammatory cytokine. Named for its first discovered function as a pre-B cell colony enhancing factor, it has since been found to have many other functions relating to cell metabolism, inflammation, and immune modulation. It has also bee...