Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease
Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respec...
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| Published in | Internal Medicine Vol. 61; no. 8; pp. 1225 - 1230 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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The Japanese Society of Internal Medicine
15.04.2022
Japan Science and Technology Agency |
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| Abstract | Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD. |
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| AbstractList | Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD. Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD.Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD. |
| ArticleNumber | 7789-21 |
| Author | Ueno, Mayumi Ueki, Toshimitsu Ichikawa, Naoaki Satomi, Hidetoshi Hiroshima, Yuki Kobayashi, Hikaru Sato, Keijiro Sumi, Masahiko |
| Author_xml | – sequence: 1 fullname: Hiroshima, Yuki organization: The Department of Hematology, Nagano Red Cross Hospital, Japan – sequence: 2 fullname: Sato, Keijiro organization: The Department of Hematology, Nagano Red Cross Hospital, Japan – sequence: 3 fullname: Ueki, Toshimitsu organization: The Department of Hematology, Nagano Red Cross Hospital, Japan – sequence: 4 fullname: Sumi, Masahiko organization: The Department of Hematology, Nagano Red Cross Hospital, Japan – sequence: 5 fullname: Ueno, Mayumi organization: The Department of Hematology, Nagano Red Cross Hospital, Japan – sequence: 6 fullname: Ichikawa, Naoaki organization: The Department of Hematology, Nagano Red Cross Hospital, Japan – sequence: 7 fullname: Satomi, Hidetoshi organization: The Department of Pathology, Nagano Red Cross Hospital, Japan – sequence: 8 fullname: Kobayashi, Hikaru organization: The Department of Hematology, Nagano Red Cross Hospital, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34565772$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1182/blood-2011-02-321315 10.1038/sj.bmt.1702098 10.1038/bmt.2016.130 10.1053/j.ajkd.2010.06.006 10.1038/sj.bmt.1705758 10.1111/j.1524-6175.2006.06042.x 10.1001/jama.293.13.1653 10.1038/bmt.2008.350 10.1016/j.beha.2008.02.003 10.1038/bmt.2017.207 10.1016/S0140-6736(09)60237-3 10.1038/bmt.2011.65 10.1136/gut.41.3.375 10.1016/j.bbmt.2007.10.008 10.1080/08880010050122889 |
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| Keywords | endothelial cell injury nitric oxide donor (NO donor) transplantation-associated microangiopathy (TAM) graft-versus-host disease (GVHD) liver dysfunction transdermal isosorbide tape |
| Language | English |
| License | The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
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| Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Report-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 Correspondence to Dr. Yuki Hiroshima, yh6@hotmail.co.jp |
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| References | 4. Thachil J. Nitric oxide in transplantation-related thrombotic microangiopathy. Bone Marrow Transplant 43: 513-514, 2009. 15. Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet 2: 1550-61, 2009. 14. Mohty M, Malard F, Abecassis M, et al. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant 51: 906-912, 2016. 6. Hollenberg NK. Organ systems dependent on nitric oxide and the potential for nitric oxide-targeted therapies in related diseases. J Clin Hypertens 8: 63-73, 2006. 10. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 293: 1653-1662, 2005. 13. Sand J, Arvola P, Jäntti V, et al. The inhibitory role of nitric oxide in the control of porcine and human sphincter of Oddi activity. Gut 41: 375-380, 1997. 9. Kajiume T, Yoshimi S, Nagita A, Kobayashi K, Kataoka N. Application of nitric oxide for a case of veno-occlusive disease after peripheral blood stem cell transplantation. Pediatr Hematol Oncol 17: 601-604, 2000. 8. Kajiume T, Nagita A, Yoshimi S, Kobayashi K, Kataoka N. A case of hemolytic uremic syndrome improved with nitric oxide. Bone Marrow Transplant 25: 109-110, 2000. 3. Carreras E, Diaz-Ricart M. The role of the endothelium in the short-term complications of hematopoietic SCT. Bone Marrow Transplant 46: 1495-1502, 2011. 5. Khosla J, Yeh AC, Spitzer TR, Dey BR. Hematopoietic stem cell transplant-associated thrombotic microangiopathy: current paradigm and novel therapies. Bone Marrow Transplant 53: 129-137, 2018. 11. Biedermann BC. Vascular endothelium and graft-versus-host disease. Best Pract Res Clin Haematol 21: 129-138, 2008. 12. Cooke KR, Jannin A, Ho V. The contribution of endothelial activation and injury to end-organ toxicity following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 14: 23-32, 2008. 1. Batts ED, Lazarus HM. Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting? Bone Marrow Transplant 40: 709-719, 2007. 2. Goldberg RJ, Nakagawa T, Johnson RJ, Thurman JM. The role of endothelial cell injury in thrombotic microangiopathy. Am J Kidney Dis 56: 1168-1174, 2010. 7. Laskin BL, Goebel J, Davies SM, Jodele S. Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Blood 118: 1452-1462, 2011. 11 12 14 JL Ferrara (15) 2009; 2 1 2 3 4 J Sand (13) 1997; 41 5 6 7 8 9 10 |
| References_xml | – reference: 4. Thachil J. Nitric oxide in transplantation-related thrombotic microangiopathy. Bone Marrow Transplant 43: 513-514, 2009. – reference: 7. Laskin BL, Goebel J, Davies SM, Jodele S. Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Blood 118: 1452-1462, 2011. – reference: 11. Biedermann BC. Vascular endothelium and graft-versus-host disease. Best Pract Res Clin Haematol 21: 129-138, 2008. – reference: 13. Sand J, Arvola P, Jäntti V, et al. The inhibitory role of nitric oxide in the control of porcine and human sphincter of Oddi activity. Gut 41: 375-380, 1997. – reference: 14. Mohty M, Malard F, Abecassis M, et al. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant 51: 906-912, 2016. – reference: 10. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 293: 1653-1662, 2005. – reference: 1. Batts ED, Lazarus HM. Diagnosis and treatment of transplantation-associated thrombotic microangiopathy: real progress or are we still waiting? Bone Marrow Transplant 40: 709-719, 2007. – reference: 2. Goldberg RJ, Nakagawa T, Johnson RJ, Thurman JM. The role of endothelial cell injury in thrombotic microangiopathy. Am J Kidney Dis 56: 1168-1174, 2010. – reference: 15. Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet 2: 1550-61, 2009. – reference: 12. Cooke KR, Jannin A, Ho V. The contribution of endothelial activation and injury to end-organ toxicity following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 14: 23-32, 2008. – reference: 9. Kajiume T, Yoshimi S, Nagita A, Kobayashi K, Kataoka N. Application of nitric oxide for a case of veno-occlusive disease after peripheral blood stem cell transplantation. Pediatr Hematol Oncol 17: 601-604, 2000. – reference: 8. Kajiume T, Nagita A, Yoshimi S, Kobayashi K, Kataoka N. A case of hemolytic uremic syndrome improved with nitric oxide. Bone Marrow Transplant 25: 109-110, 2000. – reference: 5. Khosla J, Yeh AC, Spitzer TR, Dey BR. Hematopoietic stem cell transplant-associated thrombotic microangiopathy: current paradigm and novel therapies. Bone Marrow Transplant 53: 129-137, 2018. – reference: 3. Carreras E, Diaz-Ricart M. The role of the endothelium in the short-term complications of hematopoietic SCT. Bone Marrow Transplant 46: 1495-1502, 2011. – reference: 6. Hollenberg NK. Organ systems dependent on nitric oxide and the potential for nitric oxide-targeted therapies in related diseases. J Clin Hypertens 8: 63-73, 2006. – ident: 7 doi: 10.1182/blood-2011-02-321315 – ident: 8 doi: 10.1038/sj.bmt.1702098 – ident: 14 doi: 10.1038/bmt.2016.130 – ident: 2 doi: 10.1053/j.ajkd.2010.06.006 – ident: 1 doi: 10.1038/sj.bmt.1705758 – ident: 6 doi: 10.1111/j.1524-6175.2006.06042.x – ident: 10 doi: 10.1001/jama.293.13.1653 – ident: 4 doi: 10.1038/bmt.2008.350 – ident: 11 doi: 10.1016/j.beha.2008.02.003 – ident: 5 doi: 10.1038/bmt.2017.207 – volume: 2 start-page: 1550 issn: 0140-6736 year: 2009 ident: 15 publication-title: The Lancet doi: 10.1016/S0140-6736(09)60237-3 – ident: 3 doi: 10.1038/bmt.2011.65 – volume: 41 start-page: 375 issn: 0017-5749 year: 1997 ident: 13 publication-title: Gut doi: 10.1136/gut.41.3.375 – ident: 12 doi: 10.1016/j.bbmt.2007.10.008 – ident: 9 doi: 10.1080/08880010050122889 |
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| Snippet | Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients... |
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| SubjectTerms | Bilirubin Case Report endothelial cell injury Graft versus host disease graft-versus-host disease (GVHD) Graft-versus-host reaction Internal medicine Jaundice liver dysfunction Nitric oxide nitric oxide donor (NO donor) transdermal isosorbide tape Transplantation transplantation-associated microangiopathy (TAM) |
| Title | Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease |
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