Multi-elemental bio-imaging of rat tissue from a study investigating the bioavailability of bismuth from shotgun pellets

In recent years, bismuth has been promoted as a “green element” and is used as a substitute for the toxic lead in ammunition and other applications. However, the bioavailability and toxicity of bismuth is still not very well described. Following a hunting accident with bismuth-containing shots, a bi...

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Published inAnalytical and bioanalytical chemistry Vol. 404; no. 1; pp. 89 - 99
Main Authors Urgast, Dagmar S., Ellingsen, Dag G., Berlinger, Balázs, Eilertsen, Einar, Friisk, Grete, Skaug, Vidar, Thomassen, Yngvar, Beattie, John H., Kwun, In-Sook, Feldmann, Jörg
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.07.2012
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Abstract In recent years, bismuth has been promoted as a “green element” and is used as a substitute for the toxic lead in ammunition and other applications. However, the bioavailability and toxicity of bismuth is still not very well described. Following a hunting accident with bismuth-containing shots, a bioavailability study of bismuth from metal pellets inoculated into rat limb muscles was carried out. Bismuth could be found in urine and blood of the animals. Bio-imaging using laser ablation ICP-MS of thin sections of the tissue around the metal implant was carried out to find out more about the distribution of the metal diffusing into the tissue. Two laser ablation systems with different ablation cell designs were compared regarding their analytical performance. Low concentrations of bismuth showing a non-symmetrical pattern were detected in the tissue surrounding the metal implant. This was partly an artefact from cutting the thin sections but also bio-mobilisation of the metals of the implant could be seen. An accumulation of zinc around the implant was interpreted as a marker of inflammation. Challenges regarding sample preparation for laser ablation and bio-imaging of samples of diverse composition became apparent during the analysis. Figure
AbstractList In recent years, bismuth has been promoted as a 'green element' and is used as a substitute for the toxic lead in ammunition and other applications. However, the bioavailability and toxicity of bismuth is still not very well described. Following a hunting accident with bismuth-containing shots, a bioavailability study of bismuth from metal pellets inoculated into rat limb muscles was carried out. Bismuth could be found in urine and blood of the animals. Bio-imaging using laser ablation ICP-MS of thin sections of the tissue around the metal implant was carried out to find out more about the distribution of the metal diffusing into the tissue. Two laser ablation systems with different ablation cell designs were compared regarding their analytical performance. Low concentrations of bismuth showing a non-symmetrical pattern were detected in the tissue surrounding the metal implant. This was partly an artefact from cutting the thin sections but also bio-mobilisation of the metals of the implant could be seen. An accumulation of zinc around the implant was interpreted as a marker of inflammation. Challenges regarding sample preparation for laser ablation and bio-imaging of samples of diverse composition became apparent during the analysis. Figure
In recent years, bismuth has been promoted as a "green element" and is used as a substitute for the toxic lead in ammunition and other applications. However, the bioavailability and toxicity of bismuth is still not very well described. Following a hunting accident with bismuth-containing shots, a bioavailability study of bismuth from metal pellets inoculated into rat limb muscles was carried out. Bismuth could be found in urine and blood of the animals. Bio-imaging using laser ablation ICP-MS of thin sections of the tissue around the metal implant was carried out to find out more about the distribution of the metal diffusing into the tissue. Two laser ablation systems with different ablation cell designs were compared regarding their analytical performance. Low concentrations of bismuth showing a non-symmetrical pattern were detected in the tissue surrounding the metal implant. This was partly an artefact from cutting the thin sections but also bio-mobilisation of the metals of the implant could be seen. An accumulation of zinc around the implant was interpreted as a marker of inflammation. Challenges regarding sample preparation for laser ablation and bio-imaging of samples of diverse composition became apparent during the analysis.
In recent years, bismuth has been promoted as a "green element" and is used as a substitute for the toxic lead in ammunition and other applications. However, the bioavailability and toxicity of bismuth is still not very well described. Following a hunting accident with bismuth-containing shots, a bioavailability study of bismuth from metal pellets inoculated into rat limb muscles was carried out. Bismuth could be found in urine and blood of the animals. Bio-imaging using laser ablation ICP-MS of thin sections of the tissue around the metal implant was carried out to find out more about the distribution of the metal diffusing into the tissue. Two laser ablation systems with different ablation cell designs were compared regarding their analytical performance. Low concentrations of bismuth showing a non-symmetrical pattern were detected in the tissue surrounding the metal implant. This was partly an artefact from cutting the thin sections but also bio-mobilisation of the metals of the implant could be seen. An accumulation of zinc around the implant was interpreted as a marker of inflammation. Challenges regarding sample preparation for laser ablation and bio-imaging of samples of diverse composition became apparent during the analysis. Keywords Bismuth * Bio-imaging * LA-ICP-MS * Tissue thin section * Rat
In recent years, bismuth has been promoted as a “green element” and is used as a substitute for the toxic lead in ammunition and other applications. However, the bioavailability and toxicity of bismuth is still not very well described. Following a hunting accident with bismuth-containing shots, a bioavailability study of bismuth from metal pellets inoculated into rat limb muscles was carried out. Bismuth could be found in urine and blood of the animals. Bio-imaging using laser ablation ICP-MS of thin sections of the tissue around the metal implant was carried out to find out more about the distribution of the metal diffusing into the tissue. Two laser ablation systems with different ablation cell designs were compared regarding their analytical performance. Low concentrations of bismuth showing a non-symmetrical pattern were detected in the tissue surrounding the metal implant. This was partly an artefact from cutting the thin sections but also bio-mobilisation of the metals of the implant could be seen. An accumulation of zinc around the implant was interpreted as a marker of inflammation. Challenges regarding sample preparation for laser ablation and bio-imaging of samples of diverse composition became apparent during the analysis. Figure
Audience Academic
Author Friisk, Grete
Eilertsen, Einar
Kwun, In-Sook
Ellingsen, Dag G.
Urgast, Dagmar S.
Thomassen, Yngvar
Beattie, John H.
Berlinger, Balázs
Feldmann, Jörg
Skaug, Vidar
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Keywords Bismuth
LA-ICP-MS
Rat
Tissue thin section
Bio-imaging
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PublicationTitle Analytical and bioanalytical chemistry
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Snippet In recent years, bismuth has been promoted as a “green element” and is used as a substitute for the toxic lead in ammunition and other applications. However,...
In recent years, bismuth has been promoted as a "green element" and is used as a substitute for the toxic lead in ammunition and other applications. However,...
In recent years, bismuth has been promoted as a 'green element' and is used as a substitute for the toxic lead in ammunition and other applications. However,...
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SubjectTerms Ablation
Ablation (Surgery)
Analytical Chemistry
Animals
Bioavailability
Biochemistry
Biological Availability
Bismuth
Bismuth - analysis
Bismuth - pharmacokinetics
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Firearms
Food Science
Humans
Implants
Investigations
Laboratory Medicine
Laser ablation
Laser Therapy - instrumentation
Laser Therapy - methods
Male
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Mathematical analysis
Molecular Imaging - methods
Monitoring/Environmental Analysis
Original Paper
Pellets
Rats
Rats, Wistar
Wounds, Gunshot - diagnosis
Wounds, Gunshot - metabolism
Zinc
Title Multi-elemental bio-imaging of rat tissue from a study investigating the bioavailability of bismuth from shotgun pellets
URI https://link.springer.com/article/10.1007/s00216-012-6101-9
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