Myocarditis with Advanced Atrioventricular Block after Allogeneic Stem Cell Transplantation: A Case Report and Literature Review

• Published in: Internal Medicine Vol. 59; no. 1; pp. 113 - 118
• Main Authors: Sumi, Masahiko, Kitahara, Mari, Shishido, Tsutomu, Kazumoto, Hiroko, Uematsu, Nozomu, Kirihara, Takehiko, Sato, Keijiro, Ueki, Toshimitsu, Hiroshima, Yuki, Shimizu, Kunihiko, Kobayashi, Hikaru
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2020; Japan Science and Technology Agency
• Subjects: Acute lymphoblastic leukemia; allogeneic stem cell transplantation; atrioventricular block; Atrioventricular Block - diagnosis; Atrioventricular Block - drug therapy; Atrioventricular Block - etiology; Case Report; Cord blood; Cord Blood Stem Cell Transplantation; Echocardiography; Electrocardiography; Female; Glucocorticoids - therapeutic use; Graft vs Host Disease - complications; Graft vs Host Disease - diagnosis; Graft vs Host Disease - drug therapy; graft-versus-host disease; Heart; Heart diseases; Humans; Internal medicine; Literature reviews; Lymphatic leukemia; Middle Aged; Myocarditis; Myocarditis - diagnosis; Myocarditis - drug therapy; Myocarditis - etiology; Myocardium; Philadelphia chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Prednisolone; Prednisolone - therapeutic use; Shock, Cardiogenic - diagnosis; Shock, Cardiogenic - etiology; Stem cell transplantation; Stem cells; Ventricle; α-Interferon; allogeneic stem cell transplantation; atrioventricular block; myocarditis; graft-versus-host disease

A 51-year-old woman with Philadelphia chromosome-positive acute lymphoblastic leukemia underwent a second cord blood transplantation followed by maintenance therapy with interferon-α. After 33 months, she developed cardiogenic shock caused by advanced atrioventricular block. Laboratory tests reveale...