A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics

• Published in: Cell research Vol. 25; no. 3; pp. 394 - 397
• Main Authors: Zhang, Conggang, Lee, Schuyler, Peng, Yinghua, Bunker, Eric, Shen, Chong, Giaime, Emilie, Shen, Jie, Shen, Jingshi, Zhou, Zongyao, Liu, Xuedong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2015; Nature Publishing Group
• Subjects: 631/1647/1511; 631/443/319/333; 631/80/86; 631/92/96; Animals; Base Sequence; Biomedical and Life Sciences; Cell Biology; Cell Line, Tumor; HeLa Cells; Humans; Letter to the Editor; Life Sciences; Mice; Mitochondria - genetics; Mitochondria - physiology; Mitochondrial Dynamics - genetics; Mitochondrial Dynamics - physiology; Mitophagy - physiology; Protein Kinases - genetics; Protein Kinases - metabolism; Sequence Alignment; Ubiquitin-Protein Ligases - metabolism; Valinomycin - pharmacology; 功能调节; 动力学; 化学遗传学; 探测; 神经元; 线粒体; 细胞类型; 质量控制

Dear Editor, PINK1 and Parkin have been implicated in mitochon- drial quality control, mitochondrial fusion/fission dynamics and axonal mitochondrial mobility in neurons [1, 2]. The PINK1-Parkin pathway is very dynamic and the biological responses mediated by the PINK1-Parkin pathway differ spatiall...