BDNF gene is a risk factor for schizophrenia in a Scottish population

• Published in: Molecular psychiatry Vol. 10; no. 2; pp. 208 - 212
• Main Authors: Neves-Pereira, M, Cheung, J K, Pasdar, A, Zhang, F, Breen, G, Yates, P, Sinclair, M, Crombie, C, Walker, N, St Clair, D M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2005; Nature Publishing Group
• Subjects: Adult; Adult and adolescent clinical studies; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Diagnosis; European Continental Ancestry Group - genetics; Gene Frequency; Gene polymorphism; Genetic Predisposition to Disease; Genetics, Population; Haplotypes; Humans; Linkage disequilibrium; Linkage Disequilibrium - genetics; Medical sciences; Medicine; Medicine & Public Health; Mental disorders; Methionine; Methionine - genetics; Neurosciences; original-research-article; Pharmacotherapy; Polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide - genetics; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Reference Values; Risk Factors; Schizoaffective disorder; Schizophrenia; Schizophrenia - genetics; Scotland; Single-nucleotide polymorphism; Valine; Valine - genetics; United Kingdom; Scotland; Great Britain; Europe; haplotype analysis; bipolar disorder; risk; genetics; schizophrenia; association study; Psychosis; Mood disorder; Human; Risk factor; Genetic linkage; Schizophrenia; Bipolar disorder; Brain derived neurotrophic factor; Haplotype; Polymorphism

Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, wh...