BDNF gene is a risk factor for schizophrenia in a Scottish population
Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, wh...
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Published in | Molecular psychiatry Vol. 10; no. 2; pp. 208 - 212 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.02.2005
Nature Publishing Group |
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Abstract | Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the
BDNF
gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism (SNP) showed significant (
P
=0.005) association for valine (allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (
P
<1 × 10
−8
) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population. We conclude that, although the val66met polymorphism has been reported to alter gene function, the risk may depend upon the haplotypic background on which the val/met variant is carried. |
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AbstractList | Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism (SNP) showed significant (P=0.005) association for valine (allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (P<1 × 10−8) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population. We conclude that, although the val66met polymorphism has been reported to alter gene function, the risk may depend upon the haplotypic background on which the val/met variant is carried. Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (P < 1 x 10(-8)) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population. We conclude that, although the val66met polymorphism has been reported to alter gene function, the risk may depend upon the haplotypic background on which the val/met variant is carried. Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (P < 1 x 10(-8)) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population. We conclude that, although the val66met polymorphism has been reported to alter gene function, the risk may depend upon the haplotypic background on which the val/met variant is carried. Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism (SNP) showed significant ( P =0.005) association for valine (allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant ( P <1 × 10 −8 ) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population. We conclude that, although the val66met polymorphism has been reported to alter gene function, the risk may depend upon the haplotypic background on which the val/met variant is carried. |
Audience | Academic |
Author | Crombie, C Zhang, F Sinclair, M Cheung, J K Neves-Pereira, M St Clair, D M Yates, P Breen, G Pasdar, A Walker, N |
Author_xml | – sequence: 1 givenname: M surname: Neves-Pereira fullname: Neves-Pereira, M organization: Department of Mental Health, University of Aberdeen – sequence: 2 givenname: J K surname: Cheung fullname: Cheung, J K organization: Department of Mental Health, University of Aberdeen – sequence: 3 givenname: A surname: Pasdar fullname: Pasdar, A organization: Department of Mental Health, University of Aberdeen – sequence: 4 givenname: F surname: Zhang fullname: Zhang, F organization: Department of Mental Health, University of Aberdeen – sequence: 5 givenname: G surname: Breen fullname: Breen, G organization: Institute of Psychiatry, King's College – sequence: 6 givenname: P surname: Yates fullname: Yates, P organization: Ravenscraig Hospital – sequence: 7 givenname: M surname: Sinclair fullname: Sinclair, M organization: Department of Mental Health, University of Aberdeen – sequence: 8 givenname: C surname: Crombie fullname: Crombie, C organization: Department of Mental Health, University of Aberdeen – sequence: 9 givenname: N surname: Walker fullname: Walker, N organization: Aberdeen Royal Infirmary – sequence: 10 givenname: D M surname: St Clair fullname: St Clair, D M email: ims@abdn.ac.uk organization: Department of Mental Health, University of Aberdeen |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16450657$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15630410$$D View this record in MEDLINE/PubMed |
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Keywords | haplotype analysis bipolar disorder risk genetics schizophrenia association study Psychosis Mood disorder Human Risk factor Genetic linkage Schizophrenia Bipolar disorder Brain derived neurotrophic factor Haplotype Polymorphism |
Language | English |
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PublicationTitle | Molecular psychiatry |
PublicationTitleAbbrev | Mol Psychiatry |
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PublicationYear | 2005 |
Publisher | Nature Publishing Group UK Nature Publishing Group |
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SubjectTerms | Adult Adult and adolescent clinical studies Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Bipolar Disorder - genetics Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Diagnosis European Continental Ancestry Group - genetics Gene Frequency Gene polymorphism Genetic Predisposition to Disease Genetics, Population Haplotypes Humans Linkage disequilibrium Linkage Disequilibrium - genetics Medical sciences Medicine Medicine & Public Health Mental disorders Methionine Methionine - genetics Neurosciences original-research-article Pharmacotherapy Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reference Values Risk Factors Schizoaffective disorder Schizophrenia Schizophrenia - genetics Scotland Single-nucleotide polymorphism Valine Valine - genetics |
Title | BDNF gene is a risk factor for schizophrenia in a Scottish population |
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