The Unique Cytoarchitecture of Human Pancreatic Islets Has Implications for Islet Cell Function

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 7; pp. 2334 - 2339
• Main Authors: Cabrera, Over, Berman, Dora M., Kenyon, Norma S., Ricordi, Camillo, Berggren, Per-Olof, Caicedo, Alejandro
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 14.02.2006; National Acad Sciences
• Subjects: Animals; Biological Sciences; Blood vessels; Calcium; Cells; Diabetes; Endocrine cells; Endocrine system; Female; Humans; Insulin; Ions; Islet cells; Islets of Langerhans; Islets of Langerhans - chemistry; Islets of Langerhans - cytology; Islets of Langerhans - physiology; Macaca fascicularis; Male; Medicin och hälsovetenskap; Mice; Microscopy; Microscopy, Confocal; Microscopy, Fluorescence; Middle Aged; Monkeys; Pancreatic cells; Rodents; Type 1 diabetes mellitus; Written composition

The cytoarchitecture of human islets has been examined, focusing on cellular associations that provide the anatomical framework for paracrine interactions. By using confocal microscopy and multiple immunofluorescence, we found that, contrary to descriptions of prototypical islets in textbooks and in...