Mechanisms of hepatic fibrogenesis
Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks that regulate the deposition of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cells (HSCs) into a myofibroblast-like phenotype that is contractile, proliferat...
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| Published in | Baillière's best practice & research. Clinical gastroenterology Vol. 25; no. 2; pp. 195 - 206 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.04.2011
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks that regulate the deposition of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cells (HSCs) into a myofibroblast-like phenotype that is contractile, proliferative and fibrogenic. Collagen and other extracellular matrix (ECM) components are deposited as the liver generates a wound-healing response to encapsulate injury. Sustained fibrogenesis leads to cirrhosis, characterized by a distortion of the liver parenchyma and vascular architecture. Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease. |
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| AbstractList | Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks that regulate the deposition of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cell (HSC) into a myofibroblast like phenotype that is contractile, proliferative and fibrogenic. Collagen and other extracellular matrix (ECM) components are deposited as the liver generates a wound healing response to encapsulate injury. Sustained fibrogenesis leads to cirrhosis, characterized by a distortion of the liver parenchyma and vascular architecture. Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease. Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks that regulate the deposition of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cells (HSCs) into a myofibroblast-like phenotype that is contractile, proliferative and fibrogenic. Collagen and other extracellular matrix (ECM) components are deposited as the liver generates a wound-healing response to encapsulate injury. Sustained fibrogenesis leads to cirrhosis, characterized by a distortion of the liver parenchyma and vascular architecture. Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease. Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks that regulate the deposition of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cells (HSCs) into a myofibroblast-like phenotype that is contractile, proliferative and fibrogenic. Collagen and other extracellular matrix (ECM) components are deposited as the liver generates a wound-healing response to encapsulate injury. Sustained fibrogenesis leads to cirrhosis, characterized by a distortion of the liver parenchyma and vascular architecture. Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease.Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks that regulate the deposition of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cells (HSCs) into a myofibroblast-like phenotype that is contractile, proliferative and fibrogenic. Collagen and other extracellular matrix (ECM) components are deposited as the liver generates a wound-healing response to encapsulate injury. Sustained fibrogenesis leads to cirrhosis, characterized by a distortion of the liver parenchyma and vascular architecture. Uncovering the intricate mechanisms that underlie liver fibrogenesis forms the basis for efforts to develop targeted therapies to reverse the fibrotic response and improve the outcomes of patients with chronic liver disease. |
| Author | Lee, Ursula E. Friedman, Scott L. |
| Author_xml | – sequence: 1 givenname: Ursula E. surname: Lee fullname: Lee, Ursula E. email: Ursula.lang@mssm.edu organization: Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Ave, Room 11-76, New York, NY 10029, USA – sequence: 2 givenname: Scott L. surname: Friedman fullname: Friedman, Scott L. email: Scott.Friedman@mssm.edu organization: Division of Liver Diseases, Mount Sinai School of Medicine, Box 1123, 1425 Madison Ave, Room 1170C, New York, NY 10029, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21497738$$D View this record in MEDLINE/PubMed |
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| CODEN | BPRCB6 |
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| Issue | 2 |
| Keywords | Tyrosine kinase Stellate cell Immune cells Adipokines Growth factors Fibrogenesis |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 Copyright © 2011 Elsevier Ltd. All rights reserved. |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Undefined-1 ObjectType-Feature-3 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Ursula E. Lee, Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Ave, Room 11-76, New York, NY 10029, Tel 212 659 9505, Ursula.lang@mssm.edu |
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| PublicationTitle | Baillière's best practice & research. Clinical gastroenterology |
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| SubjectTerms | Adipokines Angiogenesis Animals Apoptosis Chemokines Cytokines Epidermal growth factor Fibrogenesis Gastroenterology and Hepatology Genotype & phenotype Growth factors Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Humans Immune cells Immune system Kinases Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Phosphorylation Rodents Signal Transduction - genetics Stellate cell Tyrosine kinase Wound healing |
| Title | Mechanisms of hepatic fibrogenesis |
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