Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition

• Published in: Nature structural & molecular biology Vol. 27; no. 10; pp. 978 - 988
• Main Authors: Maezawa, So, Sakashita, Akihiko, Yukawa, Masashi, Chen, Xiaoting, Takahashi, Kazuki, Alavattam, Kris G., Nakata, Ippo, Weirauch, Matthew T., Barski, Artem, Namekawa, Satoshi H.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2020; Nature Publishing Group
• Subjects: 13; 13/100; 14; 38; 38/39; 42; 45; 45/15; 631/136; 631/208/176; Animals; Biochemistry; Biological Microscopy; Biomedical and Life Sciences; Cell Differentiation; Cellular proteins; Enhancer Elements, Genetic; Gene expression; Gene Expression Regulation; Genetic aspects; Identification and classification; Life Sciences; Male; Meiosis; Meiosis - genetics; Membrane Biology; Mice, Inbred C57BL; Mice, Transgenic; Mitosis; Mitosis - genetics; Mutation; Observations; Polycomb-Group Proteins - genetics; Polycomb-Group Proteins - metabolism; Protein Structure; Proto-Oncogene Proteins c-myb - genetics; Proto-Oncogene Proteins c-myb - metabolism; Spermatogenesis; Spermatogenesis - genetics; Spermatogonia - cytology; Spermatogonia - physiology; Trans-Activators - genetics; Trans-Activators - metabolism; X Chromosome - genetics; United States

Owing to bursts in the expression of thousands of germline-specific genes, the testis has the most diverse and complex transcriptome of all organs. By analyzing the male germline of mice, we demonstrate that the genome-wide reorganization of super-enhancers (SEs) drives bursts in germline gene expre...