Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage

• Published in: Scientific reports Vol. 8; no. 1; pp. 3363 - 18
• Main Authors: Scott, Ian C., Majithiya, Jayesh B., Sanden, Caroline, Thornton, Peter, Sanders, Philip N., Moore, Tom, Guscott, Molly, Corkill, Dominic J., Erjefält, Jonas S., Cohen, E. Suzanne
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.02.2018; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/21; 13/51; 13/95; 14/28; 631/250/127/1213; 631/250/1933; 631/250/256; 82/29; 82/83; Alarmins - metabolism; Allergens; Allergens - metabolism; Animals; Calpain - metabolism; Cell Line; Clinical Medicine; Cytokines; Cytotoxicity; Epithelial cells; Humanities and Social Sciences; Humans; Hypersensitivity; Immune response; Immunity, Innate; Inactivation; Inflammation; Interleukin 1; Interleukin-33 - chemistry; Interleukin-33 - metabolism; Klinisk medicin; Leukocytes (neutrophilic); Lung - pathology; Lungmedicin och allergi; Lymphocytes; Mast cells; Medical and Health Sciences; Medicin och hälsovetenskap; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Molecular Weight; multidisciplinary; N-Terminus; Necrosis; Necrosis - pathology; Oxidation; Proteases; Proteolysis; Respiratory Medicine and Allergy; Respiratory Mucosa - pathology; Respiratory tract; Science; Science (multidisciplinary); Serine

Interleukin (IL)-33 is an IL-1 family alarmin released from damaged epithelial and endothelial barriers to elicit immune responses and allergic inflammation via its receptor ST2. Serine proteases released from neutrophils, mast cells and cytotoxic lymphocytes have been proposed to process the N-term...