Lymphangiogenesis and tumor metastasis

• Published in: Thrombosis and haemostasis Vol. 90; no. 4; p. 591
• Main Authors: Nisato, Riccardo E, Tille, Jean-Christophe, Pepper, Michael S
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2003
• Subjects: Angiogenic Proteins - physiology; Animals; Endothelium, Lymphatic - pathology; Humans; Lymph Nodes - pathology; Lymphangiogenesis; Neoplasm Metastasis - pathology; Neoplasms - pathology; Vascular Endothelial Growth Factor C - physiology

In several human cancers, increased expression in primary tumors of vascular endothelial growth factor-C (VEGF-C) is correlated with regional lymph node metastasis. Studies using transgenic mice overexpressing VEGF-C, or xenotransplantation of VEGF-C-expressing tumor cells into immunodeficient mice,...