Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia

• Published in: Journal of affective disorders Vol. 152-154; pp. 326 - 333
• Main Authors: Ren, Xinguo, Rizavi, Hooriyah S., Khan, Mansoor A., Bhaumik, Runa, Dwivedi, Yogesh, Pandey, Ghanshyam N.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.01.2014; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Aged, 80 and over; Biological and medical sciences; Bipolar affective disorder; Bipolar disorder; Bipolar Disorder - metabolism; Bipolar disorders; Blotting, Western; Brain - metabolism; Camps; Case-Control Studies; Cingulate gyrus; Cortex; CRE-DNA binding activity; CREB; Cyclic AMP Response Element-Binding Protein - metabolism; Female; Human DLPFC; Humans; Male; Medical sciences; Middle Aged; Miscellaneous; Mood disorders; Postmortems; Proteins; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Real-Time Polymerase Chain Reaction; Schizophrenia; Schizophrenia - metabolism; Human DLPFC; Schizophrenia; Bipolar disorder; CREB; CRE-DNA binding activity; Cingulate gyrus; Mood disorder; Human; Central nervous system; Postmortem; Activity; Encephalon; Psychosis; Dorsolateral prefrontal cortex; Cingulate cortex; DNA; Transcription factor CREB

Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two...