Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia

Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two...

Full description

Saved in:
Bibliographic Details
Published inJournal of affective disorders Vol. 152-154; pp. 326 - 333
Main Authors Ren, Xinguo, Rizavi, Hooriyah S., Khan, Mansoor A., Bhaumik, Runa, Dwivedi, Yogesh, Pandey, Ghanshyam N.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier B.V 01.01.2014
Elsevier
Subjects
Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Biological and medical sciences
Bipolar affective disorder
Bipolar disorder
Bipolar Disorder - metabolism
Bipolar disorders
Blotting, Western
Brain - metabolism
Camps
Case-Control Studies
Cingulate gyrus
Cortex
CRE-DNA binding activity
CREB
Cyclic AMP Response Element-Binding Protein - metabolism
Female
Human DLPFC
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Mood disorders
Postmortems
Proteins
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Real-Time Polymerase Chain Reaction
Schizophrenia
Schizophrenia - metabolism
Human DLPFC
Schizophrenia
Bipolar disorder
CREB
CRE-DNA binding activity
Cingulate gyrus
Mood disorder
Human
Central nervous system
Postmortem
Activity
Encephalon
Psychosis
Dorsolateral prefrontal cortex
Cingulate cortex
DNA
Transcription factor CREB
Online AccessGet full text

Cover

Abstract Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e., dorsolateral prefrontal cortex (DLPFC) and cingulate gyrus (CG). We determined CREB protein expression using Western blot technique, CRE-DNA binding using gel shift assay, and mRNA expression using real-time RT-polymerase chain reaction (qPCR) in DLPFC and CG of the postmortem brain of BP (n=19), SZ (n=20), and normal control (NC, n=20) subjects. We observed that CREB protein and mRNA expression and CRE-DNA binding activity were significantly decreased in the nuclear fraction of DLPFC and CG obtained from BP subjects compared with NC subjects. However, the protein and mRNA expression and CRE-DNA binding in SZ subjects was significantly decreased in CG, but not in DLPFC, compared with NC. These studies thus indicate region-specific abnormalities of CREB expression and function in both BP and SZ. They suggest that abnormalities of CREB in CG may be associated with both BP and SZ, but its abnormality in DLPFC is specific to BP illness.
AbstractList Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e., dorsolateral prefrontal cortex (DLPFC) and cingulate gyrus (CG). We determined CREB protein expression using Western blot technique, CRE-DNA binding using gel shift assay, and mRNA expression using real-time RT-polymerase chain reaction (qPCR) in DLPFC and CG of the postmortem brain of BP (n=19), SZ (n=20), and normal control (NC, n=20) subjects. We observed that CREB protein and mRNA expression and CRE-DNA binding activity were significantly decreased in the nuclear fraction of DLPFC and CG obtained from BP subjects compared with NC subjects. However, the protein and mRNA expression and CRE-DNA binding in SZ subjects was significantly decreased in CG, but not in DLPFC, compared with NC. These studies thus indicate region-specific abnormalities of CREB expression and function in both BP and SZ. They suggest that abnormalities of CREB in CG may be associated with both BP and SZ, but its abnormality in DLPFC is specific to BP illness.
Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e., dorsolateral prefrontal cortex (DLPFC) and cingulate gyrus (CG).BACKGROUNDAbnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e., dorsolateral prefrontal cortex (DLPFC) and cingulate gyrus (CG).We determined CREB protein expression using Western blot technique, CRE-DNA binding using gel shift assay, and mRNA expression using real-time RT-polymerase chain reaction (qPCR) in DLPFC and CG of the postmortem brain of BP (n=19), SZ (n=20), and normal control (NC, n=20) subjects.METHODSWe determined CREB protein expression using Western blot technique, CRE-DNA binding using gel shift assay, and mRNA expression using real-time RT-polymerase chain reaction (qPCR) in DLPFC and CG of the postmortem brain of BP (n=19), SZ (n=20), and normal control (NC, n=20) subjects.We observed that CREB protein and mRNA expression and CRE-DNA binding activity were significantly decreased in the nuclear fraction of DLPFC and CG obtained from BP subjects compared with NC subjects. However, the protein and mRNA expression and CRE-DNA binding in SZ subjects was significantly decreased in CG, but not in DLPFC, compared with NC.RESULTSWe observed that CREB protein and mRNA expression and CRE-DNA binding activity were significantly decreased in the nuclear fraction of DLPFC and CG obtained from BP subjects compared with NC subjects. However, the protein and mRNA expression and CRE-DNA binding in SZ subjects was significantly decreased in CG, but not in DLPFC, compared with NC.These studies thus indicate region-specific abnormalities of CREB expression and function in both BP and SZ. They suggest that abnormalities of CREB in CG may be associated with both BP and SZ, but its abnormality in DLPFC is specific to BP illness.CONCLUSIONThese studies thus indicate region-specific abnormalities of CREB expression and function in both BP and SZ. They suggest that abnormalities of CREB in CG may be associated with both BP and SZ, but its abnormality in DLPFC is specific to BP illness.
Background: Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e., dorsolateral prefrontal cortex (DLPFC) and cingulate gyrus (CG). Methods: We determined CREB protein expression using Western blot technique, CRE-DNA binding using gel shift assay, and mRNA expression using real-time RT-polymerase chain reaction (qPCR) in DLPFC and CG of the postmortem brain of BP (n=19), SZ (n=20), and normal control (NC, n=20) subjects. Results: We observed that CREB protein and mRNA expression and CRE-DNA binding activity were significantly decreased in the nuclear fraction of DLPFC and CG obtained from BP subjects compared with NC subjects. However, the protein and mRNA expression and CRE-DNA binding in SZ subjects was significantly decreased in CG, but not in DLPFC, compared with NC. Conclusion: These studies thus indicate region-specific abnormalities of CREB expression and function in both BP and SZ. They suggest that abnormalities of CREB in CG may be associated with both BP and SZ, but its abnormality in DLPFC is specific to BP illness.
Background: Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e., dorsolateral prefrontal cortex (DLPFC) and cingulate gyrus (CG). Methods: We determined CREB protein expression using Western blot technique, CRE-DNA binding using gel shift assay, and mRNA expression using real-time RT-polymerase chain reaction (qPCR) in DLPFC and CG of the postmortem brain of BP (n=19), SZ (n=20), and normal control (NC, n=20) subjects. Results: We observed that CREB protein and mRNA expression and CRE-DNA binding activity were significantly decreased in the nuclear fraction of DLPFC and CG obtained from BP subjects compared with NC subjects. However, the protein and mRNA expression and CRE-DNA binding in SZ subjects was significantly decreased in CG, but not in DLPFC, compared with NC. Conclusion: These studies thus indicate region-specific abnormalities of CREB expression and function in both BP and SZ. They suggest that abnormalities of CREB in CG may be associated with both BP and SZ, but its abnormality in DLPFC is specific to BP illness. [Copyright Elsevier B.V.]
Abstract Background Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on both indirect and direct evidence. To further elucidate the role of CREB in these disorders, we studied CREB expression and function in two brain areas implicated in these disorders, i.e., dorsolateral prefrontal cortex (DLPFC) and cingulate gyrus (CG). Methods We determined CREB protein expression using Western blot technique, CRE-DNA binding using gel shift assay, and mRNA expression using real-time RT-polymerase chain reaction (qPCR) in DLPFC and CG of the postmortem brain of BP ( n =19), SZ ( n =20), and normal control (NC, n =20) subjects. Results We observed that CREB protein and mRNA expression and CRE-DNA binding activity were significantly decreased in the nuclear fraction of DLPFC and CG obtained from BP subjects compared with NC subjects. However, the protein and mRNA expression and CRE-DNA binding in SZ subjects was significantly decreased in CG, but not in DLPFC, compared with NC. Conclusion These studies thus indicate region-specific abnormalities of CREB expression and function in both BP and SZ. They suggest that abnormalities of CREB in CG may be associated with both BP and SZ, but its abnormality in DLPFC is specific to BP illness.
Author Ren, Xinguo
Khan, Mansoor A.
Dwivedi, Yogesh
Bhaumik, Runa
Pandey, Ghanshyam N.
Rizavi, Hooriyah S.
Author_xml – sequence: 1
  givenname: Xinguo
  surname: Ren
  fullname: Ren, Xinguo
– sequence: 2
  givenname: Hooriyah S.
  surname: Rizavi
  fullname: Rizavi, Hooriyah S.
– sequence: 3
  givenname: Mansoor A.
  surname: Khan
  fullname: Khan, Mansoor A.
– sequence: 4
  givenname: Runa
  surname: Bhaumik
  fullname: Bhaumik, Runa
– sequence: 5
  givenname: Yogesh
  surname: Dwivedi
  fullname: Dwivedi, Yogesh
– sequence: 6
  givenname: Ghanshyam N.
  surname: Pandey
  fullname: Pandey, Ghanshyam N.
  email: Gnpandey@psych.uic.edu
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28079208$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/24148789$$D View this record in MEDLINE/PubMed
BookMark eNqNkltrFDEcxQep2It-AF8kL4Ivs-YyyUwQCkvxBhUF9TlkMv_pZpxJxiRbWd_93ma7Wy8FWyGQQM45yUl-x8WB8w6K4jHBC4KJeD4sBt0tKCZsgeUCM3avOCK8ZiXlpD4ojrKGl5jR-rA4jnHAGAtZ4wfFIa1I1dSNPCp-LMcEQSfrHfI9MhszWlMu331AAeLsXQQEI0zgEmqt66y7QHPwCaxDeaQVoNnHNPmQYEJt0PYqJq7bAUyK6JtNq2yc_agD6mz0oYOAtOtQNCv73c-rAM7qh8X9Xo8RHu3nk-Lzq5efzt6U5-9fvz1bnpdGYJlKRnRF85IDZ7LHvKcta3pcgWx6yeretJQDawXVBISodEdlQzg0fZeLC1yxk-J0lzuv2wk6k2sFPao52EmHjfLaqr93nF2pC3-pWH4tQXgOeLYPCP7rGmJSk40GxlE78OuoCOeNlIwJ_D9SIiiuKbtbWomqkUQKmqVP_mzw6-rXP5oFT_cCHY0e-6CdsfG3rsG1pLjJunqnM8HHGKBXxqYrDnJxOyqC1ZYxNajMmNoyprBUmbHsJDec1-G3eV7sPJB_99JCUNFYcAY6GzIoqvP2VvfpDXem1Nlc7wtsIA5-HVzGRhEVqcLq45b7LfaEYVwTuX01-e-AOw7_CZ_XEps
CODEN JADID7
CitedBy_id crossref_primary_10_1177_0706743716648290
crossref_primary_10_1016_j_jbc_2023_104671
crossref_primary_10_1038_s41398_022_01936_8
crossref_primary_10_1016_j_toxrep_2023_12_008
crossref_primary_10_1016_j_ejphar_2019_172454
crossref_primary_10_1016_j_psychres_2020_113311
crossref_primary_10_1002_brb3_2466
crossref_primary_10_1186_s12915_020_00886_1
crossref_primary_10_1007_s11064_022_03798_4
crossref_primary_10_1007_s00213_020_05631_8
crossref_primary_10_1016_j_neuint_2020_104726
crossref_primary_10_2139_ssrn_3956652
crossref_primary_10_1038_s41380_024_02420_z
crossref_primary_10_3389_fnbeh_2020_00157
crossref_primary_10_1007_s00210_024_03009_7
crossref_primary_10_3389_fnmol_2018_00255
crossref_primary_10_1016_j_cellsig_2020_109592
crossref_primary_10_1016_j_neubiorev_2021_05_002
crossref_primary_10_1159_000488031
crossref_primary_10_1016_j_jpsychires_2020_07_019
crossref_primary_10_3389_fnmol_2022_1028963
crossref_primary_10_1016_j_celrep_2022_110790
crossref_primary_10_3390_biomedicines10112759
crossref_primary_10_1111_pcn_13572
crossref_primary_10_1016_j_ejphar_2023_176064
crossref_primary_10_2174_1570159X22666240206111838
crossref_primary_10_1016_j_imu_2022_100975
crossref_primary_10_1038_s41392_023_01427_2
crossref_primary_10_1038_s41386_022_01502_2
crossref_primary_10_3389_fgene_2022_849227
crossref_primary_10_25082_JPBR_2023_01_004
crossref_primary_10_1016_j_schres_2017_09_046
crossref_primary_10_3390_cells14030182
crossref_primary_10_1016_j_neubiorev_2017_01_014
crossref_primary_10_1007_s12035_024_04653_z
crossref_primary_10_1016_j_bioorg_2022_105716
crossref_primary_10_1016_j_neuint_2015_04_004
Cites_doi 10.1176/ajp.154.12.1670
10.1016/j.brainres.2009.06.103
10.1007/s702-002-8239-6
10.1016/j.biopsych.2003.10.023
10.1016/j.biopsych.2004.12.016
10.1038/sj.mp.4002099
10.1001/archpsyc.60.3.273
10.1001/archpsyc.1972.01750190059011
10.1046/j.1471-4159.2001.00495.x
10.1016/j.jpsychires.2011.08.006
10.1523/JNEUROSCI.16-07-02365.1996
10.1016/S0166-2236(99)01500-3
10.1016/S0022-3956(02)00061-4
10.1016/S0165-0327(02)00065-4
10.1016/S0006-3223(01)01080-0
10.1016/j.neubiorev.2009.01.004
10.1002/j.1460-2075.1992.tb05412.x
10.1146/annurev.biochem.68.1.821
10.1016/S0021-9258(18)31619-3
10.1017/S1461145706007231
10.1016/0167-4781(93)90191-F
10.1046/j.1471-4159.2002.00939.x
10.1001/archpsyc.57.7.685
10.1016/j.pnpbp.2004.05.040
10.1038/sj.npp.1300488
10.1111/j.1399-5618.2005.00238.x
10.1186/gb-2002-3-7-research0034
10.1034/j.1399-5618.2002.01157.x
10.1046/j.1471-4159.1999.720879.x
10.1111/j.1742-7843.2009.00416.x
10.1016/S0893-133X(01)00327-X
10.1046/j.1471-4159.1997.69062336.x
10.1016/S0165-0327(02)00332-4
10.1016/S0021-9258(19)52451-6
10.1017/S146114570400478X
10.1128/MCB.13.8.4852
10.1016/S0006-3223(01)01243-4
10.1007/s004010100392
10.1016/S0022-3956(03)00047-5
10.1016/S0896-6273(02)00828-0
10.1002/ajmg.b.30617
10.1016/j.neuroscience.2006.08.069
10.1177/070674370204700203
10.1016/j.jad.2009.10.017
10.2174/1566524033479663
10.4049/jimmunol.154.4.1717
10.1080/07853890701483270
10.1523/JNEUROSCI.20-11-04030.2000
10.1001/archpsyc.1986.01800010033004
10.1038/sj.npp.1301640
10.1016/j.tins.2005.06.005
10.1016/j.jpsychires.2009.07.009
10.1093/cercor/12.4.386
10.1016/S0306-4522(98)00627-7
10.1038/85109
10.1021/bi970982t
10.1177/0269881112463124
10.1001/archpsyc.61.5.459
10.1176/ajp.154.5.682
10.1074/jbc.271.24.14214
10.1016/S0006-3223(00)00950-1
ContentType Journal Article
Copyright 2013 Elsevier B.V.
Elsevier B.V.
2015 INIST-CNRS
2013 Published by Elsevier B.V.
2013 Elsevier B.V. All rights reserved. 2013
Copyright_xml – notice: 2013 Elsevier B.V.
– notice: Elsevier B.V.
– notice: 2015 INIST-CNRS
– notice: 2013 Published by Elsevier B.V.
– notice: 2013 Elsevier B.V. All rights reserved. 2013
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7TK
7QJ
5PM
DOI 10.1016/j.jad.2013.09.033
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
Neurosciences Abstracts
Applied Social Sciences Index & Abstracts (ASSIA)
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
Neurosciences Abstracts
Applied Social Sciences Index and Abstracts (ASSIA)
DatabaseTitleList
MEDLINE - Academic
MEDLINE

Neurosciences Abstracts
Applied Social Sciences Index and Abstracts (ASSIA)
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 1573-2517
EndPage 333
ExternalDocumentID PMC3878615
24148789
28079208
10_1016_j_jad_2013_09_033
S0165032713007192
1_s2_0_S0165032713007192
Genre Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIMH NIH HHS
  grantid: R24MH068855
– fundername: NIMH NIH HHS
  grantid: R01 MH056528
– fundername: NIMH NIH HHS
  grantid: R01MH077254
– fundername: NIMH NIH HHS
  grantid: R24 MH068855
– fundername: NIMH NIH HHS
  grantid: R01 MH077254
– fundername: National Institute of Mental Health : NIMH
  grantid: R01 MH077254 || MH
GroupedDBID ---
--K
--M
.1-
.FO
.~1
0R~
1B1
1P~
1RT
1~.
1~5
29J
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
AABNK
AAEDT
AAEDW
AAGKA
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AATTM
AAWTL
AAXKI
AAXUO
AAYWO
ABBQC
ABFNM
ABIVO
ABJNI
ABLJU
ABMAC
ABMZM
ABWVN
ABXDB
ACDAQ
ACGFS
ACHQT
ACIEU
ACIUM
ACRLP
ACRPL
ACVFH
ADBBV
ADCNI
ADEZE
ADMUD
ADNMO
ADVLN
AEBSH
AEIPS
AEKER
AENEX
AEUPX
AEVXI
AFJKZ
AFPUW
AFRHN
AFTJW
AFXIZ
AGCQF
AGHFR
AGQPQ
AGUBO
AGYEJ
AHHHB
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AJRQY
AJUYK
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
ANZVX
APXCP
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
CS3
DU5
EBS
EFJIC
EFKBS
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HEG
HMK
HMO
HMQ
HMW
HVGLF
HZ~
IHE
J1W
KOM
M29
M2V
M39
M3V
M41
MO0
N9A
O-L
O9-
OAUVE
OH0
OU-
OZT
P-8
P-9
P2P
PC.
Q38
R2-
ROL
RPZ
SAE
SCC
SDF
SDG
SDP
SEL
SES
SEW
SNS
SPCBC
SPS
SSH
SSZ
T5K
UV1
WUQ
Z5R
ZGI
~G-
0SF
AACTN
AFCTW
AFKWA
AJOXV
AMFUW
NCXOZ
RIG
AAIAV
ABLVK
ABYKQ
AJBFU
EFLBG
LCYCR
ZA5
AAYXX
AGRNS
CITATION
AALMO
ABFLS
ABPIF
ABPTK
ADALY
IPNFZ
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7TK
7QJ
5PM
ID FETCH-LOGICAL-c609t-31a42c605e539f05f2b38f04e98f937fcb25e3b62a1e664ad29815e8fd0696043
IEDL.DBID .~1
ISSN 0165-0327
1573-2517
IngestDate Thu Aug 21 18:24:14 EDT 2025
Mon Jul 21 11:42:24 EDT 2025
Mon Jul 21 10:44:27 EDT 2025
Thu Jul 10 17:05:45 EDT 2025
Thu Apr 03 06:55:56 EDT 2025
Thu Nov 24 18:35:08 EST 2022
Tue Jul 01 02:03:59 EDT 2025
Thu Apr 24 22:57:10 EDT 2025
Fri Feb 23 02:31:45 EST 2024
Sun Feb 23 10:18:53 EST 2025
Tue Aug 26 17:14:52 EDT 2025
IsPeerReviewed true
IsScholarly true
Keywords Human DLPFC
Schizophrenia
Bipolar disorder
CREB
CRE-DNA binding activity
Cingulate gyrus
Mood disorder
Human
Central nervous system
Postmortem
Activity
Encephalon
Psychosis
Dorsolateral prefrontal cortex
Cingulate cortex
DNA
Transcription factor CREB
Language English
License CC BY 4.0
2013 Published by Elsevier B.V.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c609t-31a42c605e539f05f2b38f04e98f937fcb25e3b62a1e664ad29815e8fd0696043
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
PMID 24148789
PQID 1464891962
PQPubID 23479
PageCount 8
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3878615
proquest_miscellaneous_1558993360
proquest_miscellaneous_1551620723
proquest_miscellaneous_1464891962
pubmed_primary_24148789
pascalfrancis_primary_28079208
crossref_citationtrail_10_1016_j_jad_2013_09_033
crossref_primary_10_1016_j_jad_2013_09_033
elsevier_sciencedirect_doi_10_1016_j_jad_2013_09_033
elsevier_clinicalkeyesjournals_1_s2_0_S0165032713007192
elsevier_clinicalkey_doi_10_1016_j_jad_2013_09_033
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2014-01-01
PublicationDateYYYYMMDD 2014-01-01
PublicationDate_xml – month: 01
  year: 2014
  text: 2014-01-01
  day: 01
PublicationDecade 2010
PublicationPlace Oxford
PublicationPlace_xml – name: Oxford
– name: Netherlands
PublicationTitle Journal of affective disorders
PublicationTitleAlternate J Affect Disord
PublicationYear 2014
Publisher Elsevier B.V
Elsevier
Publisher_xml – name: Elsevier B.V
– name: Elsevier
References Nibuya, Nestler, Duman (bib42) 1996; 16
Rajkowska (bib50) 2000; 48
Shaywitz, Greenberg (bib55) 1999; 68
Hardingham, Arnold, Bading (bib26) 2001; 4
Moore, Waxham, Dash (bib39) 1996; 271
Young, Bezchlibnyk, Chen, Wang, MacQueen (bib65) 2004; 55
Nestler, Greengard (bib41) 1994
Haznedar, Buchsbaum, Luu, Hazlett, Siegel, Lohr, Wu, Haier, Bunney (bib27) 1997; 154
Thome, Sakai, Shin, Steffen, Zhang, Impey, Storm, Duman (bib58) 2000; 20
Cechinel-Recco, Valvassori, Varela, Resende, Arent, Vitto, Luz, de Souza, Quevedo (bib11) 2012; 26
Fiol, Williams, Chou, Wang, Roach, Andrisani (bib18) 1994; 269
Pandey, Ren, Rizavi, Dwivedi (bib48) 2010; 44
Xie, Rothstein (bib63) 1995; 154
Carter, Mintun, Nichols, Cohen (bib10) 1997; 154
Koch, Kell, Aldenhoff (bib30) 2003; 37
Sairanen, O'Leary, Knuuttila, Castren (bib52) 2007; 144
Grimes, Jope (bib21) 2001; 78
Akin, Manier, Sanders-Bush, Shelton (bib1) 2005; 8
Boer, Cierny, Krause, Heinrich, Lin, Mayr, Hiemke, Knepel (bib5) 2008; 33
Chen, Zeng, Yuan, Huang, Jiang, Zhao, Manji (bib12) 1999; 72
Manier, Shelton, Sulser (bib38) 2002; 109
Pandey, Dwivedi, Ren, Rizavi, Roberts, Conley, Tamminga (bib46) 2003; 37
Kyosseva, Elbein, Hutton, Griffin, Mrak, Sturner, Karson (bib31) 2000; 57
Hammonds, Shim (bib25) 2009; 105
Feighner, Robins, Guze, Woodruff, Winokur, Munoz (bib17) 1972; 26
Vandesompele, De Preter, Pattyn, Poppe, Van Roy, De Paepe, Speleman (bib60) 2002; 3
Bullock, Habener (bib8) 1998; 37
Cotter, Mackay, Chana, Beasley, Landau, Everall (bib14) 2002; 12
Hunsberger, Austin, Chen, Manji (bib28) 2009; 1293
Bezchlibnyk, Young (bib4) 2002; 47
Nichols, Weih, Schmid, DeVack, Kowenz-Leutz, Luckow, Boshart, Schutz (bib43) 1992; 11
Savitz, Drevets (bib53) 2009; 33
Mai, Jope, Li (bib36) 2002; 82
Pandey, Rizavi, Ren, Fareed, Hoppensteadt, Roberts, Conley, Dwivedi (bib49) 2012; 46
Hajek, Carrey, Alda (bib23) 2005; 7
Lonze, Ginty (bib34) 2002; 35
Ozaki, Chuang (bib44) 1997; 69
Beyer, Krishnan (bib3) 2002; 4
Pandey, Dwivedi, Ren, Rizavi, Roberts, Conley (bib45) 2007; 10
Benes, Davidson, Bird (bib2) 1986; 43
Tardito, Mori, Racagni, Smeraldi, Zanardi, Perez (bib57) 2003; 76
Carlezon, Duman, Nestler (bib9) 2005; 28
Cotter, Landau, Beasley, Stevenson, Chana, MacMillan, Everall (bib13) 2002; 51
Du, Gould, Manji (bib15) 2003
Muly (bib40) 2002; 36
Tanis, Duman (bib56) 2007; 39
Yasuda, Liang, Marinova, Yahyavi, Chuang (bib64) 2009; 14
Selemon, Rajkowska (bib54) 2003; 3
Tiraboschi, Tardito, Kasahara, Moraschi, Pruneri, Gennarelli, Racagni, Popoli (bib59) 2004; 29
Bouras, Kovari, Hof, Riederer, Giannakopoulos (bib7) 2001; 102
Goodwin, Jamison (bib20) 2007
Wang, Asghari, Rockel, Young (bib62) 1999; 91
Hagiwara, Brindle, Harootunian, Armstrong, Rivier, Vale, Tsien, Montminy (bib22) 1993; 13
Borrelli, Montmayeur, Foulkes, Sassone-Corsi (bib6) 1992; 3
Haldane, Frangou (bib24) 2004; 28
Mamdani, Alda, Grof, Young, Rouleau, Turecki (bib37) 2008; 147B
Geller, Tillman, Craney, Bolhofner (bib19) 2004; 61
Judd, Akiskal (bib29) 2003; 73
Laifenfeld, Karry, Klein, Ben-Shachar (bib32) 2005; 57
Walton, Dragunow (bib61) 2000; 23
Lowry, Rosebrough, Farr, Randall (bib35) 1951; 193
Rajkowska, Halaris, Selemon (bib51) 2001; 49
Yuan, Zhou, Wang, Li, Li, Chen, Guitart, Manji (bib66) 2010; 124
Lee, Masson (bib33) 1993; 1174
Pandey, Dwivedi, SridharaRao, Ren, Janicak, Sharma (bib47) 2002; 26
Dwivedi, Rao, Rizavi, Kotowski, Conley, Roberts, Tamminga, Pandey (bib16) 2003; 60
Muly (10.1016/j.jad.2013.09.033_bib40) 2002; 36
Haznedar (10.1016/j.jad.2013.09.033_bib27) 1997; 154
Tardito (10.1016/j.jad.2013.09.033_bib57) 2003; 76
Young (10.1016/j.jad.2013.09.033_bib65) 2004; 55
Sairanen (10.1016/j.jad.2013.09.033_bib52) 2007; 144
Lowry (10.1016/j.jad.2013.09.033_bib35) 1951; 193
Tiraboschi (10.1016/j.jad.2013.09.033_bib59) 2004; 29
Vandesompele (10.1016/j.jad.2013.09.033_bib60) 2002; 3
Cechinel-Recco (10.1016/j.jad.2013.09.033_bib11) 2012; 26
Grimes (10.1016/j.jad.2013.09.033_bib21) 2001; 78
Hagiwara (10.1016/j.jad.2013.09.033_bib22) 1993; 13
Tanis (10.1016/j.jad.2013.09.033_bib56) 2007; 39
Hammonds (10.1016/j.jad.2013.09.033_bib25) 2009; 105
Pandey (10.1016/j.jad.2013.09.033_bib46) 2003; 37
Hardingham (10.1016/j.jad.2013.09.033_bib26) 2001; 4
Carlezon (10.1016/j.jad.2013.09.033_bib9) 2005; 28
Ozaki (10.1016/j.jad.2013.09.033_bib44) 1997; 69
Manier (10.1016/j.jad.2013.09.033_bib38) 2002; 109
Benes (10.1016/j.jad.2013.09.033_bib2) 1986; 43
Chen (10.1016/j.jad.2013.09.033_bib12) 1999; 72
Cotter (10.1016/j.jad.2013.09.033_bib14) 2002; 12
Judd (10.1016/j.jad.2013.09.033_bib29) 2003; 73
Pandey (10.1016/j.jad.2013.09.033_bib48) 2010; 44
Koch (10.1016/j.jad.2013.09.033_bib30) 2003; 37
Rajkowska (10.1016/j.jad.2013.09.033_bib51) 2001; 49
Akin (10.1016/j.jad.2013.09.033_bib1) 2005; 8
Geller (10.1016/j.jad.2013.09.033_bib19) 2004; 61
Xie (10.1016/j.jad.2013.09.033_bib63) 1995; 154
Feighner (10.1016/j.jad.2013.09.033_bib17) 1972; 26
Laifenfeld (10.1016/j.jad.2013.09.033_bib32) 2005; 57
Moore (10.1016/j.jad.2013.09.033_bib39) 1996; 271
Goodwin (10.1016/j.jad.2013.09.033_bib20) 2007
Beyer (10.1016/j.jad.2013.09.033_bib3) 2002; 4
Wang (10.1016/j.jad.2013.09.033_bib62) 1999; 91
Lee (10.1016/j.jad.2013.09.033_bib33) 1993; 1174
Kyosseva (10.1016/j.jad.2013.09.033_bib31) 2000; 57
Nestler (10.1016/j.jad.2013.09.033_bib41) 1994
Savitz (10.1016/j.jad.2013.09.033_bib53) 2009; 33
Nichols (10.1016/j.jad.2013.09.033_bib43) 1992; 11
Haldane (10.1016/j.jad.2013.09.033_bib24) 2004; 28
Fiol (10.1016/j.jad.2013.09.033_bib18) 1994; 269
Mamdani (10.1016/j.jad.2013.09.033_bib37) 2008; 147B
Pandey (10.1016/j.jad.2013.09.033_bib47) 2002; 26
Mai (10.1016/j.jad.2013.09.033_bib36) 2002; 82
Yasuda (10.1016/j.jad.2013.09.033_bib64) 2009; 14
Boer (10.1016/j.jad.2013.09.033_bib5) 2008; 33
Hunsberger (10.1016/j.jad.2013.09.033_bib28) 2009; 1293
Bullock (10.1016/j.jad.2013.09.033_bib8) 1998; 37
Cotter (10.1016/j.jad.2013.09.033_bib13) 2002; 51
Yuan (10.1016/j.jad.2013.09.033_bib66) 2010; 124
Du (10.1016/j.jad.2013.09.033_bib15) 2003
Selemon (10.1016/j.jad.2013.09.033_bib54) 2003; 3
Carter (10.1016/j.jad.2013.09.033_bib10) 1997; 154
Borrelli (10.1016/j.jad.2013.09.033_bib6) 1992; 3
Walton (10.1016/j.jad.2013.09.033_bib61) 2000; 23
Bezchlibnyk (10.1016/j.jad.2013.09.033_bib4) 2002; 47
Bouras (10.1016/j.jad.2013.09.033_bib7) 2001; 102
Dwivedi (10.1016/j.jad.2013.09.033_bib16) 2003; 60
Shaywitz (10.1016/j.jad.2013.09.033_bib55) 1999; 68
Nibuya (10.1016/j.jad.2013.09.033_bib42) 1996; 16
Pandey (10.1016/j.jad.2013.09.033_bib49) 2012; 46
Pandey (10.1016/j.jad.2013.09.033_bib45) 2007; 10
Lonze (10.1016/j.jad.2013.09.033_bib34) 2002; 35
Rajkowska (10.1016/j.jad.2013.09.033_bib50) 2000; 48
Hajek (10.1016/j.jad.2013.09.033_bib23) 2005; 7
Thome (10.1016/j.jad.2013.09.033_bib58) 2000; 20
19595676 - Brain Res. 2009 Oct 13;1293:76-84
11793165 - J Neural Transm (Vienna). 2002;109(1):91-9
9375664 - J Neurochem. 1997 Dec;69(6):2336-44
9521699 - Biochemistry. 1998 Mar 17;37(11):3795-809
16176432 - Bipolar Disord. 2005 Oct;7(5):393-403
12942996 - Curr Mol Med. 2003 Aug;3(5):427-36
12184808 - Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
15820228 - Biol Psychiatry. 2005 Apr 1;57(7):716-25
12622660 - Arch Gen Psychiatry. 2003 Mar;60(3):273-82
23076832 - J Psychopharmacol. 2012 Dec;26(12):1594-604
11224542 - Nat Neurosci. 2001 Mar;4(3):261-7
11063973 - Biol Psychiatry. 2000 Oct 15;48(8):766-77
15013825 - Biol Psychiatry. 2004 Mar 15;55(6):570-7
7836756 - J Immunol. 1995 Feb 15;154(4):1717-23
10652539 - Trends Neurosci. 2000 Feb;23(2):48-53
19486334 - Basic Clin Pharmacol Toxicol. 2009 Aug;105(2):113-9
11331082 - Biol Psychiatry. 2001 May 1;49(9):741-52
14907713 - J Biol Chem. 1951 Nov;193(1):265-75
19717166 - J Psychiatr Res. 2010 Feb;44(3):143-8
17049169 - Neuroscience. 2007 Jan 5;144(1):368-74
11904132 - Biol Psychiatry. 2002 Mar 1;51(5):377-86
12507745 - J Affect Disord. 2003 Jan;73(1-2):123-31
8601816 - J Neurosci. 1996 Apr 1;16(7):2365-72
11884354 - Cereb Cortex. 2002 Apr;12(4):386-94
10818138 - J Neurosci. 2000 Jun 1;20(11):4030-6
9137127 - Am J Psychiatry. 1997 May;154(5):682-4
15380855 - Prog Neuropsychopharmacol Biol Psychiatry. 2004 Sep;28(6):943-60
19428491 - Neurosci Biobehav Rev. 2009 May;33(5):699-771
11603813 - Acta Neuropathol. 2001 Oct;102(4):373-9
19913919 - J Affect Disord. 2010 Jul;124(1-2):164-9
8336722 - Mol Cell Biol. 1993 Aug;13(8):4852-9
17852035 - Ann Med. 2007;39(7):531-44
3942472 - Arch Gen Psychiatry. 1986 Jan;43(1):31-5
12071514 - Bipolar Disord. 2002 Apr;4(2):89-104
9396944 - Am J Psychiatry. 1997 Dec;154(12):1670-5
15138445 - Neuropsychopharmacology. 2004 Oct;29(10):1831-40
11790517 - Neuropsychopharmacology. 2002 Feb;26(2):216-28
1329990 - Crit Rev Oncog. 1992;3(4):321-38
12858148 - Psychopharmacol Bull. 2002 Autumn;36(4):92-105
12482470 - J Psychiatr Res. 2003 Jan-Feb;37(1):53-9
10872467 - Annu Rev Biochem. 1999;68:821-61
12849934 - J Psychiatr Res. 2003 Sep-Oct;37(5):421-32
7798217 - J Biol Chem. 1994 Dec 23;269(51):32187-93
21906753 - J Psychiatr Res. 2012 Jan;46(1):57-63
18189280 - Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):500-4
15500705 - Int J Neuropsychopharmacol. 2005 Mar;8(1):5-16
18046304 - Neuropsychopharmacology. 2008 Sep;33(10):2407-15
8662977 - J Biol Chem. 1996 Jun 14;271(24):14214-20
12091467 - J Neurochem. 2002 Jul;82(1):75-83
9930766 - J Neurochem. 1999 Feb;72(2):879-82
15982754 - Trends Neurosci. 2005 Aug;28(8):436-45
5009428 - Arch Gen Psychiatry. 1972 Jan;26(1):57-63
8373801 - Biochim Biophys Acta. 1993 Sep 23;1174(3):221-33
17925795 - Mol Psychiatry. 2009 Jan;14(1):51-9
12194863 - Neuron. 2002 Aug 15;35(4):605-23
11579131 - J Neurochem. 2001 Sep;78(6):1219-32
16978443 - Int J Neuropsychopharmacol. 2007 Oct;10(5):621-9
11926075 - Can J Psychiatry. 2002 Mar;47(2):135-48
1354612 - EMBO J. 1992 Sep;11(9):3337-46
10891039 - Arch Gen Psychiatry. 2000 Jul;57(7):685-91
15123490 - Arch Gen Psychiatry. 2004 May;61(5):459-67
10366032 - Neuroscience. 1999;91(2):771-6
12943955 - J Affect Disord. 2003 Sep;76(1-3):249-53
References_xml – volume: 39
  start-page: 531
  year: 2007
  end-page: 544
  ident: bib56
  article-title: Intracellular signaling pathways pave roads to recovery for mood disorders
  publication-title: Annals of Medicine
– volume: 147B
  start-page: 500
  year: 2008
  end-page: 504
  ident: bib37
  article-title: Lithium response and genetic variation in the CREB family of genes
  publication-title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
– volume: 44
  start-page: 143
  year: 2010
  end-page: 148
  ident: bib48
  article-title: Glycogen synthase kinase-3beta in the platelets of patients with mood disorders: effect of treatment
  publication-title: Journal of Psychiatric Research
– volume: 49
  start-page: 741
  year: 2001
  end-page: 752
  ident: bib51
  article-title: Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
  publication-title: Biological Psychiatry
– volume: 144
  start-page: 368
  year: 2007
  end-page: 374
  ident: bib52
  article-title: Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat
  publication-title: Neuroscience
– volume: 12
  start-page: 386
  year: 2002
  end-page: 394
  ident: bib14
  article-title: Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
  publication-title: Cerebral Cortex
– volume: 11
  start-page: 3337
  year: 1992
  end-page: 3346
  ident: bib43
  article-title: Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription
  publication-title: The EMBO Journal
– volume: 60
  start-page: 273
  year: 2003
  end-page: 282
  ident: bib16
  article-title: Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects
  publication-title: Archives of General Psychiatry
– volume: 46
  start-page: 57
  year: 2012
  end-page: 63
  ident: bib49
  article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims
  publication-title: Journal of Psychiatric Research
– volume: 102
  start-page: 373
  year: 2001
  end-page: 379
  ident: bib7
  article-title: Anterior cingulate cortex pathology in schizophrenia and bipolar disorder
  publication-title: Acta Neuropathologica
– volume: 61
  start-page: 459
  year: 2004
  end-page: 467
  ident: bib19
  article-title: Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype
  publication-title: Archives of General Psychiatry
– volume: 37
  start-page: 3795
  year: 1998
  end-page: 3809
  ident: bib8
  article-title: Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge
  publication-title: Biochemistry
– volume: 4
  start-page: 89
  year: 2002
  end-page: 104
  ident: bib3
  article-title: Volumetric brain imaging findings in mood disorders
  publication-title: Bipolar Disorders
– volume: 91
  start-page: 771
  year: 1999
  end-page: 776
  ident: bib62
  article-title: Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells
  publication-title: Neuroscience
– volume: 10
  start-page: 621
  year: 2007
  end-page: 629
  ident: bib45
  article-title: Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus
  publication-title: International Journal of Neuropsychopharmacology
– volume: 29
  start-page: 1831
  year: 2004
  end-page: 1840
  ident: bib59
  article-title: Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades
  publication-title: Neuropsychopharmacology
– volume: 1293
  start-page: 76
  year: 2009
  end-page: 84
  ident: bib28
  article-title: Cellular mechanisms underlying affective resiliency: the role of glucocorticoid receptor- and mitochondrially-mediated plasticity
  publication-title: Brain Research
– volume: 3
  start-page: 321
  year: 1992
  end-page: 338
  ident: bib6
  article-title: Signal transduction and gene control: the cAMP pathway
  publication-title: Critical Reviews in Oncology/Hematology
– volume: 73
  start-page: 123
  year: 2003
  end-page: 131
  ident: bib29
  article-title: The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases
  publication-title: Journal of Affective Disorders
– volume: 28
  start-page: 436
  year: 2005
  end-page: 445
  ident: bib9
  article-title: The many faces of CREB
  publication-title: Trends in Neurosciences
– volume: 154
  start-page: 1670
  year: 1997
  end-page: 1675
  ident: bib10
  article-title: Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performance
  publication-title: American Journal of Psychiatry
– volume: 26
  start-page: 216
  year: 2002
  end-page: 228
  ident: bib47
  article-title: Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients
  publication-title: Neuropsychopharmacology
– year: 1994
  ident: bib41
  article-title: Protein Phosphorylation and Regulation of Neuronal Function
– volume: 78
  start-page: 1219
  year: 2001
  end-page: 1232
  ident: bib21
  article-title: CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium
  publication-title: Journal of Neurochemistry
– volume: 16
  start-page: 2365
  year: 1996
  end-page: 2372
  ident: bib42
  article-title: Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
  publication-title: Journal of Neuroscience
– volume: 3
  start-page: 427
  year: 2003
  end-page: 436
  ident: bib54
  article-title: Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder
  publication-title: Current Molecular Medicine
– volume: 105
  start-page: 113
  year: 2009
  end-page: 119
  ident: bib25
  article-title: Effects of 4-week treatment with lithium and olanzapine on levels of brain-derived neurotrophic factor, B-cell CLL/lymphoma 2 and phosphorylated cyclic adenosine monophosphate response element-binding protein in the sub-regions of the hippocampus
  publication-title: Basic & Clinical Pharmacology & Toxicology
– volume: 33
  start-page: 699
  year: 2009
  end-page: 771
  ident: bib53
  article-title: Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide
  publication-title: Neuroscience & Biobehavioral Reviews
– volume: 13
  start-page: 4852
  year: 1993
  end-page: 4859
  ident: bib22
  article-title: Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A
  publication-title: Molecular and Cellular Biology
– volume: 36
  start-page: 92
  year: 2002
  end-page: 105
  ident: bib40
  article-title: Signal transduction abnormalities in schizophrenia: the cAMP system
  publication-title: Psychopharmacology Bulletin
– volume: 37
  start-page: 421
  year: 2003
  end-page: 432
  ident: bib46
  article-title: Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression
  publication-title: Journal of Psychiatric Research
– volume: 35
  start-page: 605
  year: 2002
  end-page: 623
  ident: bib34
  article-title: Function and regulation of CREB family transcription factors in the nervous system
  publication-title: Neuron
– volume: 193
  start-page: 265
  year: 1951
  end-page: 275
  ident: bib35
  article-title: Protein measurement with the Folin phenol reagent
  publication-title: The Journal of Biological Chemistry
– volume: 124
  start-page: 164
  year: 2010
  end-page: 169
  ident: bib66
  article-title: Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia
  publication-title: Journal of Affective Disorders
– volume: 4
  start-page: 261
  year: 2001
  end-page: 267
  ident: bib26
  article-title: Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity
  publication-title: Nature Neuroscience
– volume: 14
  start-page: 51
  year: 2009
  end-page: 59
  ident: bib64
  article-title: The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
  publication-title: Molecular Psychiatry
– volume: 37
  start-page: 53
  year: 2003
  end-page: 59
  ident: bib30
  article-title: Differential effects of fluoxetine and imipramine on the phosphorylation of the transcription factor CREB and cell-viability
  publication-title: Journal of Psychiatric Research
– volume: 1174
  start-page: 221
  year: 1993
  end-page: 233
  ident: bib33
  article-title: Transcriptional regulation by CREB and its relatives
  publication-title: Biochimica et Biophysica Acta
– volume: 26
  start-page: 57
  year: 1972
  end-page: 63
  ident: bib17
  article-title: Diagnostic criteria for use in psychiatric research
  publication-title: Archives of General Psychiatry
– volume: 72
  start-page: 879
  year: 1999
  end-page: 882
  ident: bib12
  article-title: The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
  publication-title: Journal of Neurochemistry
– volume: 68
  start-page: 821
  year: 1999
  end-page: 861
  ident: bib55
  article-title: CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals
  publication-title: Annual Review of Biochemistry
– volume: 271
  start-page: 14214
  year: 1996
  end-page: 14220
  ident: bib39
  article-title: Neuronal activity increases the phosphorylation of the transcription factor cAMP response element-binding protein (CREB) in rat hippocampus and cortex
  publication-title: The Journal of Biological Chemistry
– volume: 154
  start-page: 1717
  year: 1995
  end-page: 1723
  ident: bib63
  article-title: Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig
  publication-title: Journal of Immunology
– volume: 69
  start-page: 2336
  year: 1997
  end-page: 2344
  ident: bib44
  article-title: Lithium increases transcription factor binding to AP-1 and cyclic AMP-responsive element in cultured neurons and rat brain
  publication-title: Journal of Neurochemistry
– volume: 26
  start-page: 1594
  year: 2012
  end-page: 1604
  ident: bib11
  article-title: Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania
  publication-title: Journal of Psychopharmacology
– volume: 55
  start-page: 570
  year: 2004
  end-page: 577
  ident: bib65
  article-title: Amygdala cyclic adenosine monophosphate response element binding protein phosphorylation in patients with mood disorders: effects of diagnosis, suicide, and drug treatment
  publication-title: Biological Psychiatry
– volume: 28
  start-page: 943
  year: 2004
  end-page: 960
  ident: bib24
  article-title: New insights help define the pathophysiology of bipolar affective disorder: neuroimaging and neuropathology findings
  publication-title: Progress in Neuro-Psychopharmacology & Biological Psychiatry
– volume: 48
  start-page: 766
  year: 2000
  end-page: 777
  ident: bib50
  article-title: Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
  publication-title: Biological Psychiatry
– start-page: 411
  year: 2003
  end-page: 445
  ident: bib15
  article-title: Neurotrophic signaling in mood disorders
  publication-title: Signal Transduction and Human Disease
– volume: 47
  start-page: 135
  year: 2002
  end-page: 148
  ident: bib4
  article-title: The neurobiology of bipolar disorder: focus on signal transduction pathways and the regulation of gene expression
  publication-title: Canadian Journal of Psychiatry
– volume: 269
  start-page: 32187
  year: 1994
  end-page: 32193
  ident: bib18
  article-title: A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression
  publication-title: Journal of Biological Chemistry
– volume: 7
  start-page: 393
  year: 2005
  end-page: 403
  ident: bib23
  article-title: Neuroanatomical abnormalities as risk factors for bipolar disorder
  publication-title: Bipolar Disorders
– volume: 43
  start-page: 31
  year: 1986
  end-page: 35
  ident: bib2
  article-title: Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics
  publication-title: Archives of General Psychiatry
– volume: 20
  start-page: 4030
  year: 2000
  end-page: 4036
  ident: bib58
  article-title: cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment
  publication-title: Journal of Neuroscience
– volume: 23
  start-page: 48
  year: 2000
  end-page: 53
  ident: bib61
  article-title: Is CREB a key to neuronal survival?
  publication-title: Trends in Neurosciences
– volume: 154
  start-page: 682
  year: 1997
  end-page: 684
  ident: bib27
  article-title: Decreased anterior cingulate gyrus metabolic rate in schizophrenia
  publication-title: American Journal of Psychiatry
– volume: 33
  start-page: 2407
  year: 2008
  end-page: 2415
  ident: bib5
  article-title: Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice
  publication-title: Neuropsychopharmacology
– year: 2007
  ident: bib20
  article-title: Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression
– volume: 3
  year: 2002
  ident: bib60
  article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
  publication-title: Genome Biology
– volume: 76
  start-page: 249
  year: 2003
  end-page: 253
  ident: bib57
  article-title: Protein kinase A activity in platelets from patients with bipolar disorder
  publication-title: Journal of Affective Disorders
– volume: 57
  start-page: 685
  year: 2000
  end-page: 691
  ident: bib31
  article-title: Increased levels of transcription factors Elk-1, cyclic adenosine monophosphate response element-binding protein, and activating transcription factor 2 in the cerebellar vermis of schizophrenic patients
  publication-title: Archives of General Psychiatry
– volume: 57
  start-page: 716
  year: 2005
  end-page: 725
  ident: bib32
  article-title: Alterations in cell adhesion molecule L1 and functionally related genes in major depression: a postmortem study
  publication-title: Biological Psychiatry
– volume: 8
  start-page: 5
  year: 2005
  end-page: 16
  ident: bib1
  article-title: Signal transduction abnormalities in melancholic depression
  publication-title: International Journal of Neuropsychopharmacology
– volume: 51
  start-page: 377
  year: 2002
  end-page: 386
  ident: bib13
  article-title: The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
  publication-title: Biological Psychiatry
– volume: 82
  start-page: 75
  year: 2002
  end-page: 83
  ident: bib36
  article-title: BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents
  publication-title: Journal of Neurochemistry
– volume: 109
  start-page: 91
  year: 2002
  end-page: 99
  ident: bib38
  article-title: Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?
  publication-title: Journal of Neural Transmission
– volume: 154
  start-page: 1670
  year: 1997
  ident: 10.1016/j.jad.2013.09.033_bib10
  article-title: Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performance
  publication-title: American Journal of Psychiatry
  doi: 10.1176/ajp.154.12.1670
– volume: 1293
  start-page: 76
  year: 2009
  ident: 10.1016/j.jad.2013.09.033_bib28
  article-title: Cellular mechanisms underlying affective resiliency: the role of glucocorticoid receptor- and mitochondrially-mediated plasticity
  publication-title: Brain Research
  doi: 10.1016/j.brainres.2009.06.103
– volume: 109
  start-page: 91
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib38
  article-title: Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?
  publication-title: Journal of Neural Transmission
  doi: 10.1007/s702-002-8239-6
– volume: 55
  start-page: 570
  year: 2004
  ident: 10.1016/j.jad.2013.09.033_bib65
  article-title: Amygdala cyclic adenosine monophosphate response element binding protein phosphorylation in patients with mood disorders: effects of diagnosis, suicide, and drug treatment
  publication-title: Biological Psychiatry
  doi: 10.1016/j.biopsych.2003.10.023
– year: 1994
  ident: 10.1016/j.jad.2013.09.033_bib41
– volume: 57
  start-page: 716
  year: 2005
  ident: 10.1016/j.jad.2013.09.033_bib32
  article-title: Alterations in cell adhesion molecule L1 and functionally related genes in major depression: a postmortem study
  publication-title: Biological Psychiatry
  doi: 10.1016/j.biopsych.2004.12.016
– volume: 14
  start-page: 51
  year: 2009
  ident: 10.1016/j.jad.2013.09.033_bib64
  article-title: The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
  publication-title: Molecular Psychiatry
  doi: 10.1038/sj.mp.4002099
– volume: 60
  start-page: 273
  year: 2003
  ident: 10.1016/j.jad.2013.09.033_bib16
  article-title: Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjects
  publication-title: Archives of General Psychiatry
  doi: 10.1001/archpsyc.60.3.273
– volume: 26
  start-page: 57
  year: 1972
  ident: 10.1016/j.jad.2013.09.033_bib17
  article-title: Diagnostic criteria for use in psychiatric research
  publication-title: Archives of General Psychiatry
  doi: 10.1001/archpsyc.1972.01750190059011
– volume: 78
  start-page: 1219
  year: 2001
  ident: 10.1016/j.jad.2013.09.033_bib21
  article-title: CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium
  publication-title: Journal of Neurochemistry
  doi: 10.1046/j.1471-4159.2001.00495.x
– volume: 46
  start-page: 57
  year: 2012
  ident: 10.1016/j.jad.2013.09.033_bib49
  article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims
  publication-title: Journal of Psychiatric Research
  doi: 10.1016/j.jpsychires.2011.08.006
– volume: 16
  start-page: 2365
  year: 1996
  ident: 10.1016/j.jad.2013.09.033_bib42
  article-title: Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.16-07-02365.1996
– volume: 23
  start-page: 48
  year: 2000
  ident: 10.1016/j.jad.2013.09.033_bib61
  article-title: Is CREB a key to neuronal survival?
  publication-title: Trends in Neurosciences
  doi: 10.1016/S0166-2236(99)01500-3
– volume: 37
  start-page: 53
  year: 2003
  ident: 10.1016/j.jad.2013.09.033_bib30
  article-title: Differential effects of fluoxetine and imipramine on the phosphorylation of the transcription factor CREB and cell-viability
  publication-title: Journal of Psychiatric Research
  doi: 10.1016/S0022-3956(02)00061-4
– volume: 76
  start-page: 249
  year: 2003
  ident: 10.1016/j.jad.2013.09.033_bib57
  article-title: Protein kinase A activity in platelets from patients with bipolar disorder
  publication-title: Journal of Affective Disorders
  doi: 10.1016/S0165-0327(02)00065-4
– volume: 49
  start-page: 741
  year: 2001
  ident: 10.1016/j.jad.2013.09.033_bib51
  article-title: Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
  publication-title: Biological Psychiatry
  doi: 10.1016/S0006-3223(01)01080-0
– volume: 33
  start-page: 699
  year: 2009
  ident: 10.1016/j.jad.2013.09.033_bib53
  article-title: Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide
  publication-title: Neuroscience & Biobehavioral Reviews
  doi: 10.1016/j.neubiorev.2009.01.004
– volume: 11
  start-page: 3337
  year: 1992
  ident: 10.1016/j.jad.2013.09.033_bib43
  article-title: Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription
  publication-title: The EMBO Journal
  doi: 10.1002/j.1460-2075.1992.tb05412.x
– volume: 68
  start-page: 821
  year: 1999
  ident: 10.1016/j.jad.2013.09.033_bib55
  article-title: CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals
  publication-title: Annual Review of Biochemistry
  doi: 10.1146/annurev.biochem.68.1.821
– volume: 269
  start-page: 32187
  year: 1994
  ident: 10.1016/j.jad.2013.09.033_bib18
  article-title: A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression
  publication-title: Journal of Biological Chemistry
  doi: 10.1016/S0021-9258(18)31619-3
– volume: 10
  start-page: 621
  year: 2007
  ident: 10.1016/j.jad.2013.09.033_bib45
  article-title: Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus
  publication-title: International Journal of Neuropsychopharmacology
  doi: 10.1017/S1461145706007231
– volume: 1174
  start-page: 221
  year: 1993
  ident: 10.1016/j.jad.2013.09.033_bib33
  article-title: Transcriptional regulation by CREB and its relatives
  publication-title: Biochimica et Biophysica Acta
  doi: 10.1016/0167-4781(93)90191-F
– volume: 82
  start-page: 75
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib36
  article-title: BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents
  publication-title: Journal of Neurochemistry
  doi: 10.1046/j.1471-4159.2002.00939.x
– start-page: 411
  year: 2003
  ident: 10.1016/j.jad.2013.09.033_bib15
  article-title: Neurotrophic signaling in mood disorders
– volume: 57
  start-page: 685
  year: 2000
  ident: 10.1016/j.jad.2013.09.033_bib31
  article-title: Increased levels of transcription factors Elk-1, cyclic adenosine monophosphate response element-binding protein, and activating transcription factor 2 in the cerebellar vermis of schizophrenic patients
  publication-title: Archives of General Psychiatry
  doi: 10.1001/archpsyc.57.7.685
– volume: 36
  start-page: 92
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib40
  article-title: Signal transduction abnormalities in schizophrenia: the cAMP system
  publication-title: Psychopharmacology Bulletin
– volume: 28
  start-page: 943
  year: 2004
  ident: 10.1016/j.jad.2013.09.033_bib24
  article-title: New insights help define the pathophysiology of bipolar affective disorder: neuroimaging and neuropathology findings
  publication-title: Progress in Neuro-Psychopharmacology & Biological Psychiatry
  doi: 10.1016/j.pnpbp.2004.05.040
– volume: 29
  start-page: 1831
  year: 2004
  ident: 10.1016/j.jad.2013.09.033_bib59
  article-title: Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1300488
– volume: 7
  start-page: 393
  year: 2005
  ident: 10.1016/j.jad.2013.09.033_bib23
  article-title: Neuroanatomical abnormalities as risk factors for bipolar disorder
  publication-title: Bipolar Disorders
  doi: 10.1111/j.1399-5618.2005.00238.x
– year: 2007
  ident: 10.1016/j.jad.2013.09.033_bib20
– volume: 3
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib60
  article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
  publication-title: Genome Biology
  doi: 10.1186/gb-2002-3-7-research0034
– volume: 4
  start-page: 89
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib3
  article-title: Volumetric brain imaging findings in mood disorders
  publication-title: Bipolar Disorders
  doi: 10.1034/j.1399-5618.2002.01157.x
– volume: 72
  start-page: 879
  year: 1999
  ident: 10.1016/j.jad.2013.09.033_bib12
  article-title: The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
  publication-title: Journal of Neurochemistry
  doi: 10.1046/j.1471-4159.1999.720879.x
– volume: 105
  start-page: 113
  year: 2009
  ident: 10.1016/j.jad.2013.09.033_bib25
  article-title: Effects of 4-week treatment with lithium and olanzapine on levels of brain-derived neurotrophic factor, B-cell CLL/lymphoma 2 and phosphorylated cyclic adenosine monophosphate response element-binding protein in the sub-regions of the hippocampus
  publication-title: Basic & Clinical Pharmacology & Toxicology
  doi: 10.1111/j.1742-7843.2009.00416.x
– volume: 26
  start-page: 216
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib47
  article-title: Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients
  publication-title: Neuropsychopharmacology
  doi: 10.1016/S0893-133X(01)00327-X
– volume: 69
  start-page: 2336
  year: 1997
  ident: 10.1016/j.jad.2013.09.033_bib44
  article-title: Lithium increases transcription factor binding to AP-1 and cyclic AMP-responsive element in cultured neurons and rat brain
  publication-title: Journal of Neurochemistry
  doi: 10.1046/j.1471-4159.1997.69062336.x
– volume: 73
  start-page: 123
  year: 2003
  ident: 10.1016/j.jad.2013.09.033_bib29
  article-title: The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases
  publication-title: Journal of Affective Disorders
  doi: 10.1016/S0165-0327(02)00332-4
– volume: 193
  start-page: 265
  year: 1951
  ident: 10.1016/j.jad.2013.09.033_bib35
  article-title: Protein measurement with the Folin phenol reagent
  publication-title: The Journal of Biological Chemistry
  doi: 10.1016/S0021-9258(19)52451-6
– volume: 8
  start-page: 5
  year: 2005
  ident: 10.1016/j.jad.2013.09.033_bib1
  article-title: Signal transduction abnormalities in melancholic depression
  publication-title: International Journal of Neuropsychopharmacology
  doi: 10.1017/S146114570400478X
– volume: 13
  start-page: 4852
  year: 1993
  ident: 10.1016/j.jad.2013.09.033_bib22
  article-title: Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A
  publication-title: Molecular and Cellular Biology
  doi: 10.1128/MCB.13.8.4852
– volume: 51
  start-page: 377
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib13
  article-title: The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
  publication-title: Biological Psychiatry
  doi: 10.1016/S0006-3223(01)01243-4
– volume: 102
  start-page: 373
  year: 2001
  ident: 10.1016/j.jad.2013.09.033_bib7
  article-title: Anterior cingulate cortex pathology in schizophrenia and bipolar disorder
  publication-title: Acta Neuropathologica
  doi: 10.1007/s004010100392
– volume: 37
  start-page: 421
  year: 2003
  ident: 10.1016/j.jad.2013.09.033_bib46
  article-title: Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression
  publication-title: Journal of Psychiatric Research
  doi: 10.1016/S0022-3956(03)00047-5
– volume: 35
  start-page: 605
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib34
  article-title: Function and regulation of CREB family transcription factors in the nervous system
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)00828-0
– volume: 147B
  start-page: 500
  year: 2008
  ident: 10.1016/j.jad.2013.09.033_bib37
  article-title: Lithium response and genetic variation in the CREB family of genes
  publication-title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
  doi: 10.1002/ajmg.b.30617
– volume: 144
  start-page: 368
  year: 2007
  ident: 10.1016/j.jad.2013.09.033_bib52
  article-title: Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2006.08.069
– volume: 47
  start-page: 135
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib4
  article-title: The neurobiology of bipolar disorder: focus on signal transduction pathways and the regulation of gene expression
  publication-title: Canadian Journal of Psychiatry
  doi: 10.1177/070674370204700203
– volume: 124
  start-page: 164
  year: 2010
  ident: 10.1016/j.jad.2013.09.033_bib66
  article-title: Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia
  publication-title: Journal of Affective Disorders
  doi: 10.1016/j.jad.2009.10.017
– volume: 3
  start-page: 427
  year: 2003
  ident: 10.1016/j.jad.2013.09.033_bib54
  article-title: Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder
  publication-title: Current Molecular Medicine
  doi: 10.2174/1566524033479663
– volume: 154
  start-page: 1717
  year: 1995
  ident: 10.1016/j.jad.2013.09.033_bib63
  article-title: Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig
  publication-title: Journal of Immunology
  doi: 10.4049/jimmunol.154.4.1717
– volume: 39
  start-page: 531
  year: 2007
  ident: 10.1016/j.jad.2013.09.033_bib56
  article-title: Intracellular signaling pathways pave roads to recovery for mood disorders
  publication-title: Annals of Medicine
  doi: 10.1080/07853890701483270
– volume: 20
  start-page: 4030
  year: 2000
  ident: 10.1016/j.jad.2013.09.033_bib58
  article-title: cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.20-11-04030.2000
– volume: 43
  start-page: 31
  year: 1986
  ident: 10.1016/j.jad.2013.09.033_bib2
  article-title: Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics
  publication-title: Archives of General Psychiatry
  doi: 10.1001/archpsyc.1986.01800010033004
– volume: 33
  start-page: 2407
  year: 2008
  ident: 10.1016/j.jad.2013.09.033_bib5
  article-title: Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1301640
– volume: 28
  start-page: 436
  year: 2005
  ident: 10.1016/j.jad.2013.09.033_bib9
  article-title: The many faces of CREB
  publication-title: Trends in Neurosciences
  doi: 10.1016/j.tins.2005.06.005
– volume: 44
  start-page: 143
  year: 2010
  ident: 10.1016/j.jad.2013.09.033_bib48
  article-title: Glycogen synthase kinase-3beta in the platelets of patients with mood disorders: effect of treatment
  publication-title: Journal of Psychiatric Research
  doi: 10.1016/j.jpsychires.2009.07.009
– volume: 12
  start-page: 386
  year: 2002
  ident: 10.1016/j.jad.2013.09.033_bib14
  article-title: Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
  publication-title: Cerebral Cortex
  doi: 10.1093/cercor/12.4.386
– volume: 91
  start-page: 771
  year: 1999
  ident: 10.1016/j.jad.2013.09.033_bib62
  article-title: Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells
  publication-title: Neuroscience
  doi: 10.1016/S0306-4522(98)00627-7
– volume: 4
  start-page: 261
  year: 2001
  ident: 10.1016/j.jad.2013.09.033_bib26
  article-title: Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity
  publication-title: Nature Neuroscience
  doi: 10.1038/85109
– volume: 37
  start-page: 3795
  year: 1998
  ident: 10.1016/j.jad.2013.09.033_bib8
  article-title: Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge
  publication-title: Biochemistry
  doi: 10.1021/bi970982t
– volume: 3
  start-page: 321
  year: 1992
  ident: 10.1016/j.jad.2013.09.033_bib6
  article-title: Signal transduction and gene control: the cAMP pathway
  publication-title: Critical Reviews in Oncology/Hematology
– volume: 26
  start-page: 1594
  year: 2012
  ident: 10.1016/j.jad.2013.09.033_bib11
  article-title: Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania
  publication-title: Journal of Psychopharmacology
  doi: 10.1177/0269881112463124
– volume: 61
  start-page: 459
  year: 2004
  ident: 10.1016/j.jad.2013.09.033_bib19
  article-title: Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype
  publication-title: Archives of General Psychiatry
  doi: 10.1001/archpsyc.61.5.459
– volume: 154
  start-page: 682
  year: 1997
  ident: 10.1016/j.jad.2013.09.033_bib27
  article-title: Decreased anterior cingulate gyrus metabolic rate in schizophrenia
  publication-title: American Journal of Psychiatry
  doi: 10.1176/ajp.154.5.682
– volume: 271
  start-page: 14214
  year: 1996
  ident: 10.1016/j.jad.2013.09.033_bib39
  article-title: Neuronal activity increases the phosphorylation of the transcription factor cAMP response element-binding protein (CREB) in rat hippocampus and cortex
  publication-title: The Journal of Biological Chemistry
  doi: 10.1074/jbc.271.24.14214
– volume: 48
  start-page: 766
  year: 2000
  ident: 10.1016/j.jad.2013.09.033_bib50
  article-title: Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
  publication-title: Biological Psychiatry
  doi: 10.1016/S0006-3223(00)00950-1
– reference: 12507745 - J Affect Disord. 2003 Jan;73(1-2):123-31
– reference: 15138445 - Neuropsychopharmacology. 2004 Oct;29(10):1831-40
– reference: 11884354 - Cereb Cortex. 2002 Apr;12(4):386-94
– reference: 7798217 - J Biol Chem. 1994 Dec 23;269(51):32187-93
– reference: 9930766 - J Neurochem. 1999 Feb;72(2):879-82
– reference: 9396944 - Am J Psychiatry. 1997 Dec;154(12):1670-5
– reference: 17852035 - Ann Med. 2007;39(7):531-44
– reference: 10818138 - J Neurosci. 2000 Jun 1;20(11):4030-6
– reference: 19486334 - Basic Clin Pharmacol Toxicol. 2009 Aug;105(2):113-9
– reference: 16176432 - Bipolar Disord. 2005 Oct;7(5):393-403
– reference: 15500705 - Int J Neuropsychopharmacol. 2005 Mar;8(1):5-16
– reference: 12942996 - Curr Mol Med. 2003 Aug;3(5):427-36
– reference: 18046304 - Neuropsychopharmacology. 2008 Sep;33(10):2407-15
– reference: 1329990 - Crit Rev Oncog. 1992;3(4):321-38
– reference: 9375664 - J Neurochem. 1997 Dec;69(6):2336-44
– reference: 12194863 - Neuron. 2002 Aug 15;35(4):605-23
– reference: 5009428 - Arch Gen Psychiatry. 1972 Jan;26(1):57-63
– reference: 15380855 - Prog Neuropsychopharmacol Biol Psychiatry. 2004 Sep;28(6):943-60
– reference: 15013825 - Biol Psychiatry. 2004 Mar 15;55(6):570-7
– reference: 11926075 - Can J Psychiatry. 2002 Mar;47(2):135-48
– reference: 12622660 - Arch Gen Psychiatry. 2003 Mar;60(3):273-82
– reference: 15820228 - Biol Psychiatry. 2005 Apr 1;57(7):716-25
– reference: 10872467 - Annu Rev Biochem. 1999;68:821-61
– reference: 8336722 - Mol Cell Biol. 1993 Aug;13(8):4852-9
– reference: 12184808 - Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
– reference: 12071514 - Bipolar Disord. 2002 Apr;4(2):89-104
– reference: 9521699 - Biochemistry. 1998 Mar 17;37(11):3795-809
– reference: 12482470 - J Psychiatr Res. 2003 Jan-Feb;37(1):53-9
– reference: 16978443 - Int J Neuropsychopharmacol. 2007 Oct;10(5):621-9
– reference: 12849934 - J Psychiatr Res. 2003 Sep-Oct;37(5):421-32
– reference: 1354612 - EMBO J. 1992 Sep;11(9):3337-46
– reference: 19913919 - J Affect Disord. 2010 Jul;124(1-2):164-9
– reference: 11224542 - Nat Neurosci. 2001 Mar;4(3):261-7
– reference: 19428491 - Neurosci Biobehav Rev. 2009 May;33(5):699-771
– reference: 11793165 - J Neural Transm (Vienna). 2002;109(1):91-9
– reference: 15123490 - Arch Gen Psychiatry. 2004 May;61(5):459-67
– reference: 17925795 - Mol Psychiatry. 2009 Jan;14(1):51-9
– reference: 18189280 - Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):500-4
– reference: 21906753 - J Psychiatr Res. 2012 Jan;46(1):57-63
– reference: 8662977 - J Biol Chem. 1996 Jun 14;271(24):14214-20
– reference: 10652539 - Trends Neurosci. 2000 Feb;23(2):48-53
– reference: 8601816 - J Neurosci. 1996 Apr 1;16(7):2365-72
– reference: 8373801 - Biochim Biophys Acta. 1993 Sep 23;1174(3):221-33
– reference: 10891039 - Arch Gen Psychiatry. 2000 Jul;57(7):685-91
– reference: 12943955 - J Affect Disord. 2003 Sep;76(1-3):249-53
– reference: 19595676 - Brain Res. 2009 Oct 13;1293:76-84
– reference: 12858148 - Psychopharmacol Bull. 2002 Autumn;36(4):92-105
– reference: 12091467 - J Neurochem. 2002 Jul;82(1):75-83
– reference: 14907713 - J Biol Chem. 1951 Nov;193(1):265-75
– reference: 15982754 - Trends Neurosci. 2005 Aug;28(8):436-45
– reference: 10366032 - Neuroscience. 1999;91(2):771-6
– reference: 17049169 - Neuroscience. 2007 Jan 5;144(1):368-74
– reference: 11904132 - Biol Psychiatry. 2002 Mar 1;51(5):377-86
– reference: 3942472 - Arch Gen Psychiatry. 1986 Jan;43(1):31-5
– reference: 19717166 - J Psychiatr Res. 2010 Feb;44(3):143-8
– reference: 11331082 - Biol Psychiatry. 2001 May 1;49(9):741-52
– reference: 11579131 - J Neurochem. 2001 Sep;78(6):1219-32
– reference: 11063973 - Biol Psychiatry. 2000 Oct 15;48(8):766-77
– reference: 11790517 - Neuropsychopharmacology. 2002 Feb;26(2):216-28
– reference: 11603813 - Acta Neuropathol. 2001 Oct;102(4):373-9
– reference: 23076832 - J Psychopharmacol. 2012 Dec;26(12):1594-604
– reference: 7836756 - J Immunol. 1995 Feb 15;154(4):1717-23
– reference: 9137127 - Am J Psychiatry. 1997 May;154(5):682-4
SSID ssj0006970
Score 2.2872705
Snippet Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia (SZ), based on...
Abstract Background Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and...
Background: Abnormalities of cyclic-AMP (cAMP) response element binding protein (CREB) function has been suggested in bipolar (BP) illness and schizophrenia...
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 326
SubjectTerms Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Biological and medical sciences
Bipolar affective disorder
Bipolar disorder
Bipolar Disorder - metabolism
Bipolar disorders
Blotting, Western
Brain - metabolism
Camps
Case-Control Studies
Cingulate gyrus
Cortex
CRE-DNA binding activity
CREB
Cyclic AMP Response Element-Binding Protein - metabolism
Female
Human DLPFC
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Mood disorders
Postmortems
Proteins
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Real-Time Polymerase Chain Reaction
Schizophrenia
Schizophrenia - metabolism
Title Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0165032713007192
https://www.clinicalkey.es/playcontent/1-s2.0-S0165032713007192
https://dx.doi.org/10.1016/j.jad.2013.09.033
https://www.ncbi.nlm.nih.gov/pubmed/24148789
https://www.proquest.com/docview/1464891962
https://www.proquest.com/docview/1551620723
https://www.proquest.com/docview/1558993360
https://pubmed.ncbi.nlm.nih.gov/PMC3878615
Volume 152-154
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELem8YKEEIiv8lEZiSekUMd27PixmpgKiAkJJu3NchJbZCpptLQPe9kb_zd3TtKtMIpE1YemvUvS8-XubN_9jpA3qTKhVJlPpNQskVVgidPSJ6UxLgf3By46on2eqMWp_HiWnR2Qo7EWBtMqB9vf2_RorYdvZoM0Z21dz75iIQ4TXOOGjIZABSvYpUYtf3d1neahTGwYh8QJUo87mzHH69whWGgqeqhT8TffdK91HUgs9K0ubotFf0-pvOGjjh-Q-0NwSef9_T8kB755RH7OlxE5GQaArgItL8tlXSbzz1_oRZ8f66nvc8hpUccaFxrBG-qGwhviQ9quuvWPmJRLC-wogafpNgWu4HQUF3KBscUpMq0GLE_qmop2N_P5HpPT4_ffjhbJ0HwhKRUza7DNTnL4mPlMmMCywAuRBya9yQOENKEseOZFobhLvVLSVdzkaebzUIHIFZPiCTlsVo1_RqisBLycBjeYyiovDNcMXETG4ZxVKMKEsFHsthyQybFBxtKOKWjnFkbK4khZZiyM1IS83bK0PSzHPmI-jqUd603BQlpwGvuY9G1Mvhue8c6mtuOW2T_0cELklnNHlf91wemOmm3_F-IVGc7yCXk96p0FG4AbO67xq02H0zeZG7ClfA8N7ohyprnYSwPTbyEUm5CnvT5f34WEibPODchlR9O3BIhTvvtLU3-PeOUC-CBwfv5_cnlB7sKR7Je9XpLD9cXGv4JAcF1M45M-JXfmHz4tTn4BLNZegA
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Nb9MwFLfGOICEJhAfC4NhJLgghTq248QHDhUwdexDSGzSbsZJbJGppNXcCu3Cjb-If5BnJ-lWGEVCWpVD1fi5znvO-7Cffw-hF4mQthSpiTnPSMwrS2KdcROXUuoczB-Y6ID2eShGx_zDSXqyhn72Z2F8WmWn-1udHrR198ug4-ZgWteDT_4gDmE08xsyGTgqXWblnjn_BnGbe7P7DoT8ktKd90dvR3FXWiAuBZEz0DyaU_iampRJS1JLC5Zbwo3MLRhsWxY0NawQVCdGCK4rKvMkNbmtiPBwJgz6vYFuclAXvmzC6-8XeSVChgp1fnSxH16_lRqSyk61RydNWIutyv5mDO9MtQMR2ba2xlXO7-85nJeM4s5dtNF5s3jYMuweWjPNffRjOA5QzSBxPLG4PC_HdRkPDz7iszYh12DTJq3jog6HanBAi6gbDBc4pHg6cbOvIQsYF76Ehe_GzQu_ZOSwXzkGwqmPyXHVgYdi3VTYXU4gfICOr0UkD9F6M2nMJsK8YvDRGdjdhFd5IWlGwCalFPqsbGEjRHq2q7KDQvcVOcaqz3k7VSAp5SWliFQgqQi9WpBMWxyQVY1pL0vVH3AFlazASq0iyq4iMq5TKk4lylFF1B8TP0J8Qbn07vzrD7eXptniuTxAkqQkj9Dzft4pUDp-J0k3ZjJ3Pl7kuQTlTVe08VuwlGSUrWwD8T5jgkToUTufL0bBIVLPcgl8WZrpiwYeGH35TlN_CQDpDOjAU3_8f3x5hm6Njg721f7u4d4Wug13eLvm9gStz87m5il4obNiO7z1GH2-bjXzC0P6mOQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Alteration+of+cyclic-AMP+response+element+binding+protein+in+the+postmortem+brain+of+subjects+with+bipolar+disorder+and+schizophrenia&rft.jtitle=Journal+of+affective+disorders&rft.au=Ren%2C+Xinguo&rft.au=Rizavi%2C+Hooriyah+S.&rft.au=Khan%2C+Mansoor+A.&rft.au=Bhaumik%2C+Runa&rft.date=2014-01-01&rft.pub=Elsevier+B.V&rft.issn=0165-0327&rft.eissn=1573-2517&rft.volume=152-154&rft.spage=326&rft.epage=333&rft_id=info:doi/10.1016%2Fj.jad.2013.09.033&rft.externalDocID=S0165032713007192
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01650327%2FS0165032713X00187%2Fcov150h.gif