Live cell imaging of mechanotransduction

• Published in: Journal of the Royal Society interface Vol. 7; no. Suppl-3; pp. S365 - S375
• Main Authors: Liu, Bo, Kim, Tae-Jin, Wang, Yingxiao
• Format: Journal Article
• Language: English
• Published: England The Royal Society 06.06.2010
• Subjects: Biomechanical Phenomena; Calcium - metabolism; Cytoskeleton - physiology; Fluorescence Resonance Energy Transfer; Fluorescence Resonance Energy Transfer - methods; Luminescent Proteins - metabolism; Mechanotransduction; Mechanotransduction, Cellular - physiology; Microscopy, Fluorescence - methods; Shear Stress; Stretch; Substrate Stiffness

Mechanical forces play important roles in the regulation of cellular functions, including polarization, migration and stem cell differentiation. Tremendous advancement in our understanding of mechanotransduction has been achieved with the recent development of imaging technologies and molecular bios...