Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes

• Published in: Thrombosis research Vol. 124; no. 3; pp. 306 - 310
• Main Authors: Shaw, George J., Meunier, Jason M., Huang, Shao-Ling, Lindsell, Christopher J., McPherson, David D., Holland, Christy K.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.07.2009; Elsevier
• Subjects: Acute ischemic stroke; Biological and medical sciences; Blood and lymphatic vessels; Blood Coagulation - drug effects; Blood Coagulation - physiology; Blood vessels and receptors; Cardiology. Vascular system; Combined Modality Therapy; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Echogenic liposomes; Fundamental and applied biological sciences. Psychology; Hematology, Oncology and Palliative Medicine; Humans; Liposomes - chemistry; Liposomes - radiation effects; Medical sciences; Regular; Thrombolytic Therapy - methods; Tissue plasminogen activator; Tissue Plasminogen Activator - administration & dosage; Tissue Plasminogen Activator - chemistry; Ultrasonic Therapy - methods; Ultrasound; Vertebrates: cardiovascular system; Echogenic liposomes; Acute ischemic stroke; Tissue plasminogen activator; Ultrasound; Cerebral infarction; Nervous system diseases; Stroke; Serine endopeptidases; Enzyme; Liposome; Cardiovascular disease; t-Plasminogen activator; Cerebral disorder; Vascular disease; Peptidases; Central nervous system disease; Brain ischemia; Hydrolases; Cerebrovascular disease

Currently, the only FDA-approved therapy for acute ischemic stroke is the administration of recombinant tissue plasminogen activator (tPA). Echogenic liposomes (ELIP), phospholipid vesicles filled with gas and fluid, can be manufactured to incorporate tPA. Also, transcranial ultrasound-enhanced thro...