An NAD Derivative Produced During Transfer RNA Splicing: ADP-Ribose 1″-2″ Cyclic Phosphate
Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final step of this process is removal of the 2′ phosphate generated at the splice junction during ligation. A nicotinamide adenine dinucleotide (NA...
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| Published in | Science (American Association for the Advancement of Science) Vol. 261; no. 5118; pp. 206 - 208 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for the Advancement of Science
09.07.1993
American Association for the Advancement of Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final step of this process is removal of the 2′ phosphate generated at the splice junction during ligation. A nicotinamide adenine dinucleotide (NAD)-dependent phosphotransferase catalyzes removal of the 2′ phosphate and produces a small molecule. It is shown here that this small molecule is an NAD derivative: adenosine diphosphate (ADP)-ribose 1″-2″ cyclic phosphate. Evidence is also presented that this molecule is produced in Xenopus laevis oocytes as a result of dephosphorylation of ligated tRNA. |
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| AbstractList | Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final step of this process is removal of the 2' phosphate generated at the splice junction during ligation. A nicotinamide adenine dinucleotide (NAD)-dependent phosphotransferase catalyzes removal of the 2' phosphate and produces a small molecule. It is shown here that this small molecule is an NAD derivative: adenosine diphosphate (ADP)-ribose 1"-2" cyclic phosphate. Evidence is also presented that this molecule is produced in Xenopus laevis oocytes as a result of dephosphorylation of ligated tRNA. Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final step of this process is removal of the 2′ phosphate generated at the splice junction during ligation. A nicotinamide adenine dinucleotide (NAD)-dependent phosphotransferase catalyzes removal of the 2′ phosphate and produces a small molecule. It is shown here that this small molecule is an NAD derivative: adenosine diphosphate (ADP)-ribose 1"-2" cyclic phosphate. Evidence is also presented that this molecule is produced in Xenopus laevis oocytes as a result of dephosphorylation of ligated tRNA. Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final step of this process is removal of the 2' phosphate generated at the splice junction during ligation. A nicotinamide adenine dinucleatide (NAD) - dependent phosphotransferase catalyzes removal of the 2' phosphate and produces a small molecule. It is shown here that this small molecule is an NAD derivative: adenosine diphosphate (ADP) - ribose 1"-2" cyclic phosphate. Evidence is also presented that this molecule is produced in Xenopus laevis oocytes as a result of dephosphorylation of ligated tRNA. |
| Audience | Academic |
| Author | Kierzek, Ryszard Turner, Douglas H. Culver, Gloria M. McCraith, Stephen M. LaReau, Richard D. Michaud, Neil Zillmann, Martin Phizicky, Eric M. |
| Author_xml | – sequence: 1 givenname: Gloria M. surname: Culver fullname: Culver, Gloria M. – sequence: 2 givenname: Stephen M. surname: McCraith fullname: McCraith, Stephen M. – sequence: 3 givenname: Martin surname: Zillmann fullname: Zillmann, Martin – sequence: 4 givenname: Ryszard surname: Kierzek fullname: Kierzek, Ryszard – sequence: 5 givenname: Neil surname: Michaud fullname: Michaud, Neil – sequence: 6 givenname: Richard D. surname: LaReau fullname: LaReau, Richard D. – sequence: 7 givenname: Douglas H. surname: Turner fullname: Turner, Douglas H. – sequence: 8 givenname: Eric M. surname: Phizicky fullname: Phizicky, Eric M. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8392224$$D View this record in MEDLINE/PubMed |
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| Snippet | Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final... Transfer RNA (tRNA) splicing is essential in Saccharomyces cerevisiae as well as in humans, and many of its features are the same in both. In yeast, the final... |
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| SubjectTerms | Adenosine Diphosphate Ribose - analogs & derivatives Adenosine Diphosphate Ribose - chemistry Adenosine Diphosphate Ribose - metabolism Animals Cyclic ADP-Ribose Endoribonucleases - metabolism Enzymes Genetic engineering Introns Molecules NAD (Coenzyme) NAD - chemistry NAD - metabolism Nicotinamide adenine dinucleotide Oocytes Oocytes - metabolism Phosphatases Phosphates Phosphates - metabolism Phosphorylation Phosphotransferases - metabolism Product labeling RNA Splicing RNA, Fungal - metabolism RNA, Transfer - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Splicing Transfer RNA Xenopus Xenopus laevis Yeasts |
| Title | An NAD Derivative Produced During Transfer RNA Splicing: ADP-Ribose 1″-2″ Cyclic Phosphate |
| URI | https://www.jstor.org/stable/2881816 https://www.ncbi.nlm.nih.gov/pubmed/8392224 https://search.proquest.com/docview/16662462 https://search.proquest.com/docview/75862008 |
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