Cobalt Chloride Induces Expression and Function of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Renal Proximal Tubular Epithelial Cell Line HK-2

• Published in: Biological & pharmaceutical bulletin Vol. 40; no. 1; pp. 82 - 87
• Main Authors: Nishihashi, Katsuki, Kawashima, Kei, Nomura, Takami, Urakami-Takebayashi, Yumiko, Miyazaki, Makoto, Takano, Mikihisa, Nagai, Junya
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.01.2017; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Accumulation; Activation; Antineoplastic drugs; Antitumor agents; ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics; ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism; Binding sites; Breast cancer; breast cancer resistance protein; Cell Line; Cell Survival - drug effects; Chloride; Clear cell-type renal cell carcinoma; Cobalt; Cobalt - pharmacology; Cobalt chloride; Cytotoxicity; Deoxyribonucleic acid; DNA; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Excretion; Fluorescein; Fluorescein isothiocyanate; Gene expression; Glucose transporter; Glucose Transporter Type 1 - genetics; Humans; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factors; Kidneys; Methotrexate; Methotrexate - pharmacology; Mitoxantrone; Mitoxantrone - pharmacology; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Regulatory sequences; Renal cell carcinoma; Renal function; renal proximal tubular epithelial cell; RNA, Messenger - metabolism; Substrate inhibition; Substrates

The human breast cancer resistance protein (BCRP/ABCG2), a member of the ATP-binding cassette transporter family, is a drug transporter restricting absorption and enhancing excretion of many compounds including anticancer drugs. The cis-regulatory elements in the BCRP promoter include a hypoxia resp...